COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11173 |
Resumo: | Federal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, Brasil |
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Oliveira Filho, Jamary deOrnellas, Ana C. PZhang, Cathy ROliveira, Luciana M. BSantos, Théo de AraújoBorges, Valeria de MatosVentura, Laís Maria Gomes de BritoReis, Francisco J. F. BAras Junior, RoqueFernandes, André MRosand, JonathanGreenberg, Steven MFurie, Karen LRost, Natalia S2015-07-08T17:14:00Z2015-07-08T17:14:00Z2015OLIVEIRA FILHO, J. et al. COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. Journal of Stroke and Cerebrovascular Diseases, may, 20151052-3057https://www.arca.fiocruz.br/handle/icict/1117310.1016/j.strokecerebrovasdis.2015.04.018engNational Stroke AssociationCOX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, BrasilFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, BrasilMassachusetts General Hospital. Stroke Division. Boston, USAFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal do Oeste da Bahia. Barreiras, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, BrasilFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, BrasilFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, BrasilFederal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, BrasilMassachusetts General Hospital. Stroke Division. Boston, USAMassachusetts General Hospital. Stroke Division. Boston, USABrown University. Department of Neurology. Providence, USAMassachusetts General Hospital. Stroke Division. Boston, USABackground: To investigate the effect of COX-2 polymorphism and its product, prostaglandin E2 (PGE2), on stroke risk in an endemic area for Chagas disease. In a separate cohort, to investigate the effect of COX-2 polymorphisms on the total burden of cerebral white matter disease. Methods: Cases were outpatients with ischemic stroke; controls were stroke-free subjects from 2 outpatient clinics (heart failure and caregivers of a movement disorders clinic). We extracted DNA from total blood to investigate the rs20417 COX-2 polymorphism. Serologic tests (Enzime-linked immunosorbent assay) were performed to confirm Trypanosoma cruzi infection and to quantify PGE2 levels. In the Boston cohort, white matter hyperintensity volume (WMHv) was quantified on the admission brain magnetic resonance images of subjects with ischemic stroke, who also donated DNA for the COX-2 gene region analysis. Results: We studied 44 patients with stroke and 96 controls (46 with heart failure and 50 caregivers) in the Brazilian cohort; and 788 stroke patients (302 cardioembolic and 486 noncardioembolic) in the Boston cohort. In the Brazilian cohort, rs20417 polymorphism was associated with both stroke (P 5 5 3 1026 ) and decreased PGE2 levels (P 5 4 3 1025 ); similarly, Chagas was associated with stroke (P 5 4 3 1023 ) and decreased PGE2 levels (P 5 7 3 1023 ). In the Boston cohort, rs20417 polymorphism was associated with increased WMHv among noncardioembolic (P 5.037), but not among cardioembolic stroke patients. Conclusions: Variation in COX-2 gene is associated with both symptomatic and silent brain cerebrovascular disease. This candidate gene region should be tested in population-based samplesAcute cerebral infarctionGenetics of strokeMagnetic resonance imagingChagas didseaseCyclooxygenaseProstaglandin E2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11173/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALOliveira Filho J COX-2....pdfOliveira Filho J COX-2....pdfapplication/pdf190222https://www.arca.fiocruz.br/bitstream/icict/11173/2/Oliveira%20Filho%20J%20COX-2....pdf9dfaab550a1a7710b53cad6e34ed2c1dMD52TEXTOliveira Filho J COX-2....pdf.txtOliveira Filho J COX-2....pdf.txtExtracted texttext/plain29119https://www.arca.fiocruz.br/bitstream/icict/11173/3/Oliveira%20Filho%20J%20COX-2....pdf.txta711403e29be9e2dd48bc83b8a9cdf73MD53icict/111732023-03-15 14:33:07.771oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| title |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| spellingShingle |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. Oliveira Filho, Jamary de Acute cerebral infarction Genetics of stroke Magnetic resonance imaging Chagas didsease Cyclooxygenase Prostaglandin E2 |
| title_short |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| title_full |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| title_fullStr |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| title_full_unstemmed |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| title_sort |
COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. |
| author |
Oliveira Filho, Jamary de |
| author_facet |
Oliveira Filho, Jamary de Ornellas, Ana C. P Zhang, Cathy R Oliveira, Luciana M. B Santos, Théo de Araújo Borges, Valeria de Matos Ventura, Laís Maria Gomes de Brito Reis, Francisco J. F. B Aras Junior, Roque Fernandes, André M Rosand, Jonathan Greenberg, Steven M Furie, Karen L Rost, Natalia S |
| author_role |
author |
| author2 |
Ornellas, Ana C. P Zhang, Cathy R Oliveira, Luciana M. B Santos, Théo de Araújo Borges, Valeria de Matos Ventura, Laís Maria Gomes de Brito Reis, Francisco J. F. B Aras Junior, Roque Fernandes, André M Rosand, Jonathan Greenberg, Steven M Furie, Karen L Rost, Natalia S |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira Filho, Jamary de Ornellas, Ana C. P Zhang, Cathy R Oliveira, Luciana M. B Santos, Théo de Araújo Borges, Valeria de Matos Ventura, Laís Maria Gomes de Brito Reis, Francisco J. F. B Aras Junior, Roque Fernandes, André M Rosand, Jonathan Greenberg, Steven M Furie, Karen L Rost, Natalia S |
| dc.subject.en.pt_BR.fl_str_mv |
Acute cerebral infarction Genetics of stroke Magnetic resonance imaging Chagas didsease Cyclooxygenase Prostaglandin E2 |
| topic |
Acute cerebral infarction Genetics of stroke Magnetic resonance imaging Chagas didsease Cyclooxygenase Prostaglandin E2 |
| description |
Federal University of Bahia. Stroke and Cardyomiopathy Clinics. Salvador, BA, Brasil / Brazilian National Research Committee. Instituto Nacional de Ciencia e tecnologia em Doenças Tropicais. Salvador, BA, Brasil |
| publishDate |
2015 |
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2015-07-08T17:14:00Z |
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2015-07-08T17:14:00Z |
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2015 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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OLIVEIRA FILHO, J. et al. COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. Journal of Stroke and Cerebrovascular Diseases, may, 2015 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/11173 |
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1052-3057 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.strokecerebrovasdis.2015.04.018 |
| identifier_str_mv |
OLIVEIRA FILHO, J. et al. COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. Journal of Stroke and Cerebrovascular Diseases, may, 2015 1052-3057 10.1016/j.strokecerebrovasdis.2015.04.018 |
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National Stroke Association |
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National Stroke Association |
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