id CRUZ_13a78091a4cfd482c6c935d9cc673cd8
oai_identifier_str oai:www.arca.fiocruz.br:icict/6404
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Saines, Karin NielsenWatts, HeatherSantos, Valdiléa Gonçalves Veloso dosBryson, Yvonne J.João Filho, Esaú CustódioPilotto, Jose Henrique da SilvaGray, Glenda E.Theron, GerhardSantos, Breno RiegelFonseca, Rosana Campos daKreitchmann, RegisPinto, JorgePinhata, Marisa Marcia MussiCeriotto, MarianaMachado, DaisyBethel, JamesMorgado, Mariza GonçalvesDickover, RuthCamarca, MargaretMirochnick, MarkSiberry, GeorgeGrinsztejn, BeatrizMoreira, RonaldoBastos, Francisco Inácio Pinkusfeld MonteiroXu, JiahongMoye, JackMofenson, Lynne M.2013-03-27T13:23:08Z2013-03-27T13:23:08Z2012NIELSEN-SAINES Karin et al. Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection. The New England Journal of Medicine, Massachusetts, v. 366, n. 25, p. 2368-2379, 21 jun. 20120028-47931533-4406https://www.arca.fiocruz.br/handle/icict/640410.1056/NEJMoa1108275The Eunice Kennedy Shriver National Institute of Child Health and Human Development [NICHD] and othersUniversity of California Los Angeles David Geffen School of Medicine, CA, Estados UnidosEunice Kennedy Shriver National Institute Of Child Health And Human Development. Maryland, MD, Estados UnidosFundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Centro de Pesquisa Clínica Em Hiv Aids.Riod e Janeiro, RJ, BrasilUniversity of California Los Angeles David Geffen School of Med icine, CA, Estados UnidosHospital dos Servidores do Estado, Rio de Janeiro, RJ, BrasilHospital Geral de Nova Iguaçu, Rio de Janeiro, RJ, BrasilUniversity of Witwatersrand. Perinatal HIV Research Unit. , South AfricaFaculty of Medicine. Department of Obstetrics and Gynecology.Tygerberg, South AfricaGrupo Hospitalar Conceição. Hospital Nossa Senhora da Conceição. Departamento de Doenças Infecciosas. Porto Alegre, RS, BrasilHospital Fêmina. Porto Alegre, RS, BrasilIrmandade da Santa Casa de Misericordia de Porto Alegre. Porto Alegre, RS, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Minas Gerais, MG, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Puericultura e Pediatria. Ribeirão Preto, SP, BrasilFoundation for Maternal and Infant Health, Buenos Aires, BS, ArgentinaUniversidade Federal de Sao Paulo. Sao Paulo, SP, BrasilThe Children's Hospital of Philadelphia Research Institute. Pensilvania, PA, Estados UnidosFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilUniversity of California Davis, California, CA, Estados UnidosNational Institute of Child Health and Human Development . Maryland, MD, Estados UnidosBoston University School of Medicine. Massachusetts, MA, Estados UnidosEunice Kennedy Shriver National Institute Of Child Health And Human Development. Maryland, MD, Estados UnidosUniversity of Witwatersrand and Chris Hani Baragwanath Hospital.Johannesburgo, JNB, Africa do SulFundação Oswaldo Cruz.Instituto de Comunicação e Informação Cientifica e Tecnológica em Saúde. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz.Instituto de Comunicação e Informação Cientifica e Tecnológica em Saúde. Rio de Janeiro, RJ, BrasilEunice Kennedy Shriver National Institute Of Child Health And Human Development. Maryland, MD, Estados UnidosEunice Kennedy Shriver National Institute Of Child Health And Human Development. Maryland, MD, Estados UnidosEunice Kennedy Shriver National Institute Of Child Health And Human Development. Maryland, MD, Estados UnidosBackground The safety and efficacy of adding antiretroviral drugs to standard zidovudine prophylaxis in infants of mothers with human immunodeficiency virus (HIV) infection who did not receive antenatal antiretroviral therapy (ART) because of late identification are unclear. We evaluated three ART regimens in such infants. Methods Within 48 hours after their birth, we randomly assigned formula-fed infants born to women with a peripartum diagnosis of HIV type 1 (HIV-1) infection to one of three regimens: zidovudine for 6 weeks (zidovudine-alone group), zidovudine for 6 weeks plus three doses of nevirapine during the first 8 days of life (two-drug group), or zidovudine for 6 weeks plus nelfinavir and lamivudine for 2 weeks (three-drug group). The primary outcome was HIV-1 infection at 3 months in infants uninfected at birth. Results A total of 1684 infants were enrolled in the Americas and South Africa (566 in the zidovudine-alone group, 562 in the two-drug group, and 556 in the three-drug group). The overall rate of in utero transmission of HIV-1 on the basis of Kaplan–Meier estimates was 5.7% (93 infants), with no significant differences among the groups. Intrapartum transmission occurred in 24 infants in the zidovudine-alone group (4.8%; 95% confidence interval [CI], 3.2 to 7.1), as compared with 11 infants in the two-drug group (2.2%; 95% CI, 1.2 to 3.9; P = 0.046) and 12 in the three-drug group (2.4%; 95% CI, 1.4 to 4.3; P = 0.046). The overall transmission rate was 8.5% (140 infants), with an increased rate in the zidovudine-alone group (P = 0.03 for the comparisons with the two- and three-drug groups). On multivariate analysis, zidovudine monotherapy, a higher maternal viral load, and maternal use of illegal substances were significantly associated with transmission. The rate of neutropenia was significantly increased in the three-drug group (P<0.001 for both comparisons with the other groups). Conclusions In neonates whose mothers did not receive ART during pregnancy, prophylaxis with a two- or three-drug ART regimen is superior to zidovudine alone for the prevention of intrapartum HIV transmission; the two-drug regimen has less toxicity than the threedrug regimen.engMassachusetts Medical SocietyThree Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleKaplan-Meier EstimateAntiretroviral Therapy, Highly Active /utilizationZidovudine /therapeutic usePrenatal Diagnosis /utilizationHIV-1 /pathogenicityNevirapine /therapeutic useHIV Antigens /therapeutic useAmericas /epidemiologyAfrica /epidemiologyEstimativa de Kaplan-MeierTerapia Antirretroviral de Alta Atividade /utilizaçãoZidovudina /uso terapêuticoDiagnóstico Pré-Natal /utilizaçãoHIV-1 /patogenicidadeNevirapina /uso terapêuticoAntígenos HIV /uso terapêuticoAméricas /epidemiologiaÁfrica /epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThree Postpartum Antiretroviral Regimens.pdfThree Postpartum Antiretroviral Regimens.pdfapplication/pdf294824https://www.arca.fiocruz.br/bitstream/icict/6404/2/Three%20Postpartum%20Antiretroviral%20Regimens.pdf90af1d7b9e587f1ac38e86d95ee5ee38MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6404/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTThree Postpartum Antiretroviral Regimens.pdf.txtThree Postpartum Antiretroviral Regimens.pdf.txtExtracted texttext/plain51829https://www.arca.fiocruz.br/bitstream/icict/6404/6/Three%20Postpartum%20Antiretroviral%20Regimens.pdf.txt43ca750ea7e8fd99576ae5ac04aa5b8bMD56THUMBNAILThree Postpartum Antiretroviral Regimens.pdf.jpgThree Postpartum Antiretroviral Regimens.pdf.jpgGenerated Thumbnailimage/jpeg2180https://www.arca.fiocruz.br/bitstream/icict/6404/5/Three%20Postpartum%20Antiretroviral%20Regimens.pdf.jpgaf2c67eb307ad4a370291b7f77bec45fMD55icict/64042023-08-23 15:29:33.761oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-23T18:29:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
title Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
spellingShingle Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
Saines, Karin Nielsen
Kaplan-Meier Estimate
Antiretroviral Therapy, Highly Active /utilization
Zidovudine /therapeutic use
Prenatal Diagnosis /utilization
HIV-1 /pathogenicity
Nevirapine /therapeutic use
HIV Antigens /therapeutic use
Americas /epidemiology
Africa /epidemiology
Estimativa de Kaplan-Meier
Terapia Antirretroviral de Alta Atividade /utilização
Zidovudina /uso terapêutico
Diagnóstico Pré-Natal /utilização
HIV-1 /patogenicidade
Nevirapina /uso terapêutico
Antígenos HIV /uso terapêutico
Américas /epidemiologia
África /epidemiologia
title_short Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
title_full Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
title_fullStr Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
title_full_unstemmed Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
title_sort Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection
author Saines, Karin Nielsen
author_facet Saines, Karin Nielsen
Watts, Heather
Santos, Valdiléa Gonçalves Veloso dos
Bryson, Yvonne J.
João Filho, Esaú Custódio
Pilotto, Jose Henrique da Silva
Gray, Glenda E.
Theron, Gerhard
Santos, Breno Riegel
Fonseca, Rosana Campos da
Kreitchmann, Regis
Pinto, Jorge
Pinhata, Marisa Marcia Mussi
Ceriotto, Mariana
Machado, Daisy
Bethel, James
Morgado, Mariza Gonçalves
Dickover, Ruth
Camarca, Margaret
Mirochnick, Mark
Siberry, George
Grinsztejn, Beatriz
Moreira, Ronaldo
Bastos, Francisco Inácio Pinkusfeld Monteiro
Xu, Jiahong
Moye, Jack
Mofenson, Lynne M.
author_role author
author2 Watts, Heather
Santos, Valdiléa Gonçalves Veloso dos
Bryson, Yvonne J.
João Filho, Esaú Custódio
Pilotto, Jose Henrique da Silva
Gray, Glenda E.
Theron, Gerhard
Santos, Breno Riegel
Fonseca, Rosana Campos da
Kreitchmann, Regis
Pinto, Jorge
Pinhata, Marisa Marcia Mussi
Ceriotto, Mariana
Machado, Daisy
Bethel, James
Morgado, Mariza Gonçalves
Dickover, Ruth
Camarca, Margaret
Mirochnick, Mark
Siberry, George
Grinsztejn, Beatriz
Moreira, Ronaldo
Bastos, Francisco Inácio Pinkusfeld Monteiro
Xu, Jiahong
Moye, Jack
Mofenson, Lynne M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saines, Karin Nielsen
Watts, Heather
Santos, Valdiléa Gonçalves Veloso dos
Bryson, Yvonne J.
João Filho, Esaú Custódio
Pilotto, Jose Henrique da Silva
Gray, Glenda E.
Theron, Gerhard
Santos, Breno Riegel
Fonseca, Rosana Campos da
Kreitchmann, Regis
Pinto, Jorge
Pinhata, Marisa Marcia Mussi
Ceriotto, Mariana
Machado, Daisy
Bethel, James
Morgado, Mariza Gonçalves
Dickover, Ruth
Camarca, Margaret
Mirochnick, Mark
Siberry, George
Grinsztejn, Beatriz
Moreira, Ronaldo
Bastos, Francisco Inácio Pinkusfeld Monteiro
Xu, Jiahong
Moye, Jack
Mofenson, Lynne M.
dc.subject.en.pt_BR.fl_str_mv Kaplan-Meier Estimate
Antiretroviral Therapy, Highly Active /utilization
Zidovudine /therapeutic use
Prenatal Diagnosis /utilization
HIV-1 /pathogenicity
Nevirapine /therapeutic use
HIV Antigens /therapeutic use
Americas /epidemiology
Africa /epidemiology
topic Kaplan-Meier Estimate
Antiretroviral Therapy, Highly Active /utilization
Zidovudine /therapeutic use
Prenatal Diagnosis /utilization
HIV-1 /pathogenicity
Nevirapine /therapeutic use
HIV Antigens /therapeutic use
Americas /epidemiology
Africa /epidemiology
Estimativa de Kaplan-Meier
Terapia Antirretroviral de Alta Atividade /utilização
Zidovudina /uso terapêutico
Diagnóstico Pré-Natal /utilização
HIV-1 /patogenicidade
Nevirapina /uso terapêutico
Antígenos HIV /uso terapêutico
Américas /epidemiologia
África /epidemiologia
dc.subject.decs.pt_BR.fl_str_mv Estimativa de Kaplan-Meier
Terapia Antirretroviral de Alta Atividade /utilização
Zidovudina /uso terapêutico
Diagnóstico Pré-Natal /utilização
HIV-1 /patogenicidade
Nevirapina /uso terapêutico
Antígenos HIV /uso terapêutico
Américas /epidemiologia
África /epidemiologia
description The Eunice Kennedy Shriver National Institute of Child Health and Human Development [NICHD] and others
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2013-03-27T13:23:08Z
dc.date.available.fl_str_mv 2013-03-27T13:23:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NIELSEN-SAINES Karin et al. Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection. The New England Journal of Medicine, Massachusetts, v. 366, n. 25, p. 2368-2379, 21 jun. 2012
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6404
dc.identifier.issn.none.fl_str_mv 0028-4793
1533-4406
dc.identifier.doi.none.fl_str_mv 10.1056/NEJMoa1108275
identifier_str_mv NIELSEN-SAINES Karin et al. Three Postpartum Antiretroviral Regimens to Prevent Intrapartum HIV Infection. The New England Journal of Medicine, Massachusetts, v. 366, n. 25, p. 2368-2379, 21 jun. 2012
0028-4793
1533-4406
10.1056/NEJMoa1108275
url https://www.arca.fiocruz.br/handle/icict/6404
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Massachusetts Medical Society
publisher.none.fl_str_mv Massachusetts Medical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/6404/2/Three%20Postpartum%20Antiretroviral%20Regimens.pdf
https://www.arca.fiocruz.br/bitstream/icict/6404/3/license.txt
https://www.arca.fiocruz.br/bitstream/icict/6404/6/Three%20Postpartum%20Antiretroviral%20Regimens.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/6404/5/Three%20Postpartum%20Antiretroviral%20Regimens.pdf.jpg
bitstream.checksum.fl_str_mv 90af1d7b9e587f1ac38e86d95ee5ee38
7d48279ffeed55da8dfe2f8e81f3b81f
43ca750ea7e8fd99576ae5ac04aa5b8b
af2c67eb307ad4a370291b7f77bec45f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009025912012800