Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42874 |
Resumo: | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil. |
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Bittencourt, Najara CarneiroSilva, Ana Beatriz Iung Enembreck daVirgili, Natália SilveiraSchappo, Ana PaulaGervásio, João Henrique D. B.Pimenta, Tamirys S.Kujbida Junior, Mario A.Ventura, Ana Maria R. S.Libonati, Rosana M. F.Silva-Filho, João LuizSantos, Hellen Geremias dosLopes, Stefanie C. P.Lacerda, Marcus V. G.Machado, Ricardo L. D.Costa, Fabio T. M.Albrecht, Letusa2020-08-21T20:50:56Z2020-08-21T20:50:56Z2020BITTENCOURT, Najara Carneiro et al. Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response. PLoS Negl Trop Dis., v. 14, n. 7, p. 1-21, 2020.1935-2735https://www.arca.fiocruz.br/handle/icict/4287410.1371/journal.pntd.00084711935-2735porPublic Library of SciencePlasmodium vivaxAMA1Malaria, VivaxDrug ResistanceVaccinesAntigensMalaria VivaxResistencia a MedicamentosVacunasAntígenosPaludisme à Plasmodium vivaxRésistance aux substancesVaccinsAntigènesMalária VivaxResistência a MedicamentosVacinasAntígenosPlasmodium vivax AMA1: Implications of distinct haplotypes for immune responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.In Brazil, Plasmodium vivax infection accounts for around 80% of malaria cases. This infection has a substantial impact on the productivity of the local population as the course of the disease is usually prolonged and the development of acquired immunity in endemic areas takes several years. The recent emergence of drug-resistant strains has intensified research on alternative control methods such as vaccines. There is currently no effective available vaccine against malaria; however, numerous candidates have been studied in the past several years. One of the leading candidates is apical membrane antigen 1 (AMA1). This protein is involved in the invasion of Apicomplexa parasites into host cells, participating in the formation of a moving junction. Understanding how the genetic diversity of an antigen influences the immune response is highly important for vaccine development. In this study, we analyzed the diversity of AMA1 from Brazilian P. vivax isolates and 19 haplotypes of P. vivax were found. Among those sequences, 33 nonsynonymous PvAMA1 amino acid sites were identified, whereas 20 of these sites were determined to be located in predicted B-cell epitopes. Nonsynonymous mutations were evaluated for their influence on the immune recognition of these antigens. Two distinct haplotypes, 5 and 16, were expressed and evaluated for reactivity in individuals from northern Brazil. Both PvAMA1 variants were reactive. Moreover, the IgG antibody response to these two PvAMA1 variants was analyzed in an exposed but noninfected population from a P. vivax endemic area. Interestingly, over 40% of this population had antibodies recognizing both variants. These results have implications for the design of a vaccine based on a polymorphic antigen.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/42874/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALpntd.0008471ok.pdfpntd.0008471ok.pdfapplication/pdf2290399https://www.arca.fiocruz.br/bitstream/icict/42874/2/pntd.0008471ok.pdfa3a645c40206f3cdfc489edf589ed8efMD52TEXTpntd.0008471ok.pdf.txtpntd.0008471ok.pdf.txtExtracted texttext/plain69165https://www.arca.fiocruz.br/bitstream/icict/42874/3/pntd.0008471ok.pdf.txt934934d74721536e55c0fa96e1866b33MD53icict/428742020-08-22 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| dc.title.pt_BR.fl_str_mv |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| title |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| spellingShingle |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response Bittencourt, Najara Carneiro Plasmodium vivax AMA1 Malaria, Vivax Drug Resistance Vaccines Antigens Malaria Vivax Resistencia a Medicamentos Vacunas Antígenos Paludisme à Plasmodium vivax Résistance aux substances Vaccins Antigènes Malária Vivax Resistência a Medicamentos Vacinas Antígenos |
| title_short |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| title_full |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| title_fullStr |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| title_full_unstemmed |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| title_sort |
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response |
| author |
Bittencourt, Najara Carneiro |
| author_facet |
Bittencourt, Najara Carneiro Silva, Ana Beatriz Iung Enembreck da Virgili, Natália Silveira Schappo, Ana Paula Gervásio, João Henrique D. B. Pimenta, Tamirys S. Kujbida Junior, Mario A. Ventura, Ana Maria R. S. Libonati, Rosana M. F. Silva-Filho, João Luiz Santos, Hellen Geremias dos Lopes, Stefanie C. P. Lacerda, Marcus V. G. Machado, Ricardo L. D. Costa, Fabio T. M. Albrecht, Letusa |
| author_role |
author |
| author2 |
Silva, Ana Beatriz Iung Enembreck da Virgili, Natália Silveira Schappo, Ana Paula Gervásio, João Henrique D. B. Pimenta, Tamirys S. Kujbida Junior, Mario A. Ventura, Ana Maria R. S. Libonati, Rosana M. F. Silva-Filho, João Luiz Santos, Hellen Geremias dos Lopes, Stefanie C. P. Lacerda, Marcus V. G. Machado, Ricardo L. D. Costa, Fabio T. M. Albrecht, Letusa |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bittencourt, Najara Carneiro Silva, Ana Beatriz Iung Enembreck da Virgili, Natália Silveira Schappo, Ana Paula Gervásio, João Henrique D. B. Pimenta, Tamirys S. Kujbida Junior, Mario A. Ventura, Ana Maria R. S. Libonati, Rosana M. F. Silva-Filho, João Luiz Santos, Hellen Geremias dos Lopes, Stefanie C. P. Lacerda, Marcus V. G. Machado, Ricardo L. D. Costa, Fabio T. M. Albrecht, Letusa |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium vivax AMA1 |
| topic |
Plasmodium vivax AMA1 Malaria, Vivax Drug Resistance Vaccines Antigens Malaria Vivax Resistencia a Medicamentos Vacunas Antígenos Paludisme à Plasmodium vivax Résistance aux substances Vaccins Antigènes Malária Vivax Resistência a Medicamentos Vacinas Antígenos |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria, Vivax Drug Resistance Vaccines Antigens |
| dc.subject.es.pt_BR.fl_str_mv |
Malaria Vivax Resistencia a Medicamentos Vacunas Antígenos |
| dc.subject.fr.pt_BR.fl_str_mv |
Paludisme à Plasmodium vivax Résistance aux substances Vaccins Antigènes |
| dc.subject.decs.pt_BR.fl_str_mv |
Malária Vivax Resistência a Medicamentos Vacinas Antígenos |
| description |
Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil. |
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2020 |
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2020-08-21T20:50:56Z |
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2020-08-21T20:50:56Z |
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2020 |
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info:eu-repo/semantics/article |
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BITTENCOURT, Najara Carneiro et al. Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response. PLoS Negl Trop Dis., v. 14, n. 7, p. 1-21, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42874 |
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1935-2735 |
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10.1371/journal.pntd.0008471 |
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1935-2735 |
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BITTENCOURT, Najara Carneiro et al. Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response. PLoS Negl Trop Dis., v. 14, n. 7, p. 1-21, 2020. 1935-2735 10.1371/journal.pntd.0008471 |
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