Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46049 |
Resumo: | Michigan State University. College of Veterinary Medicine. Michigan, USA. |
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Hadi, Syeda AnumKolte, Ida ViktoriaBrenner, EvanCunha, Eunice A. TotumiSimonsen, VeraFerrazoli, LucilaineVillela, Daniel A. MacielSantos, Reinaldo Souza dosRavi, JananiSreevatsan, SrinandBasta, Paulo Cesar2021-02-11T19:46:20Z2021-02-11T19:46:20Z2021HADI, Syeda Anum et al. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports, v. 11, n. 1, p. 1-12, 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4604910.1038/s41598-020-79621-32045-2322engNature Publishing GroupTuberculosePopulações VulneráveisPopulação IndígenaTuberculosisVulnerable PopulationsIndigenous PopulationsTuberculosisVulnerable PopulationsIdentification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMichigan State University. College of Veterinary Medicine. Michigan, USA.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Michigan State University. College of Veterinary Medicine. Michigan, USA.Laboratório Central de Saúde Pública de Mato Grosso do Sul. Campo Grande, MS, Brasil.Instituto Adolfo Lutz. São Paulo, SP, Brasil.Instituto Adolfo Lutz. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Michigan State University. College of Veterinary Medicine. Michigan, USA.Michigan State University. College of Veterinary Medicine. Michigan, USA.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay and the Brazilian state of Mato Grosso do Sul. This community, marginalized in Brazilian society, experiences severe poverty. Like other South American indigenous populations, their TB prevalence is high, but the disease has remained largely unstudied in their communities. Herein, Mycobacterium tuberculosis isolates from local clinics were whole genome sequenced, and a population genetic framework was generated. Phylogenetics show M. tuberculosis isolates in the Guarani-Kaiowá people cluster away from selected reference strains, suggesting divergence. Most cluster in a single group, further characterized as M. tuberculosis sublineage 4.3.3. Closer analysis of SNPs showed numerous variants across the genome, including in drug resistance-associated genes, and with many unique changes fixed in each group. We report that local M. tuberculosis strains have acquired unique polymorphisms in the Guarani-Kaiowá people, and drug resistance characterization is urgently needed to inform public health to ensure proper care and avoid further evolution and spread of drug-resistant TB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46049/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALIdentificationPredominant.pdfIdentificationPredominant.pdfapplication/pdf2031161https://www.arca.fiocruz.br/bitstream/icict/46049/2/IdentificationPredominant.pdfa1832642a10521cc41aa35356db2e099MD52TEXTIdentificationPredominant.pdf.txtIdentificationPredominant.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| title |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| spellingShingle |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population Hadi, Syeda Anum Tuberculose Populações Vulneráveis População Indígena Tuberculosis Vulnerable Populations Indigenous Populations Tuberculosis Vulnerable Populations |
| title_short |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| title_full |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| title_fullStr |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| title_full_unstemmed |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| title_sort |
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population |
| author |
Hadi, Syeda Anum |
| author_facet |
Hadi, Syeda Anum Kolte, Ida Viktoria Brenner, Evan Cunha, Eunice A. Totumi Simonsen, Vera Ferrazoli, Lucilaine Villela, Daniel A. Maciel Santos, Reinaldo Souza dos Ravi, Janani Sreevatsan, Srinand Basta, Paulo Cesar |
| author_role |
author |
| author2 |
Kolte, Ida Viktoria Brenner, Evan Cunha, Eunice A. Totumi Simonsen, Vera Ferrazoli, Lucilaine Villela, Daniel A. Maciel Santos, Reinaldo Souza dos Ravi, Janani Sreevatsan, Srinand Basta, Paulo Cesar |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Hadi, Syeda Anum Kolte, Ida Viktoria Brenner, Evan Cunha, Eunice A. Totumi Simonsen, Vera Ferrazoli, Lucilaine Villela, Daniel A. Maciel Santos, Reinaldo Souza dos Ravi, Janani Sreevatsan, Srinand Basta, Paulo Cesar |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Populações Vulneráveis População Indígena |
| topic |
Tuberculose Populações Vulneráveis População Indígena Tuberculosis Vulnerable Populations Indigenous Populations Tuberculosis Vulnerable Populations |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Vulnerable Populations Indigenous Populations |
| dc.subject.decs.pt_BR.fl_str_mv |
Tuberculosis Vulnerable Populations |
| description |
Michigan State University. College of Veterinary Medicine. Michigan, USA. |
| publishDate |
2021 |
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2021-02-11T19:46:20Z |
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2021-02-11T19:46:20Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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HADI, Syeda Anum et al. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports, v. 11, n. 1, p. 1-12, 2021. |
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https://www.arca.fiocruz.br/handle/icict/46049 |
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2045-2322 |
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10.1038/s41598-020-79621-3 |
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2045-2322 |
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HADI, Syeda Anum et al. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports, v. 11, n. 1, p. 1-12, 2021. 2045-2322 10.1038/s41598-020-79621-3 |
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Nature Publishing Group |
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Nature Publishing Group |
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