Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Valdivia, Hugo Oswaldo
Data de Publicação: 2017
Outros Autores: Almeida, Laila Vieira, Roatt, Bruno Mendes, Cunha, João Luís Reis, Pereira, Agnes Antônia Sampaio, Gontijo, Celia Maria Ferreira, Fujiwara, Ricardo Toshio, Reis, Alexandre Barbosa, Sanders, Mandy J., Cotton, James A., Bartholomeu, Daniella Castanheira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26752
Resumo: 2020-01-01
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spelling Valdivia, Hugo OswaldoAlmeida, Laila VieiraRoatt, Bruno MendesCunha, João Luís ReisPereira, Agnes Antônia SampaioGontijo, Celia Maria FerreiraFujiwara, Ricardo ToshioReis, Alexandre BarbosaSanders, Mandy J.Cotton, James A.Bartholomeu, Daniella Castanheira2018-06-06T18:25:39Z2018-06-06T18:25:39Z2017VALDIVIA, Hugo Oswaldo et al. Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil. Sci Rep., v. 7, 40804, 20172045-2322https://www.arca.fiocruz.br/handle/icict/2675210.1038/srep40804engNature Publishing GroupLeishmaniosevetoresLeishmania amazonensisLeishmaniasisvectoresLeishmania amazonensisComparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. PeruUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilWellcome Trust Sanger Institute. Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UKWellcome Trust Sanger Institute. Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UKUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil/Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales. PeruLeishmaniasis is a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania. These parasites are taxonomically diverse, with human pathogenic species separated into two subgenera according to their development site inside the alimentary tract of the sand fly insect vector. The disease encompasses a variable spectrum of clinical manifestations with tegumentary or visceral symptoms. Among the causative species in Brazil, Leishmania (Leishmania) amazonensis is an important etiological agent of human cutaneous leishmaniasis that accounts for more than 8% of all cases in endemic regions. L. (L.) amazonensis is generally found in the north and northeast regions of Brazil. Here, we report the first isolation of L. (L.) amazonensis from dogs with clinical manifestations of visceral leishmaniasis in Governador Valadares, an endemic focus in the southeastern Brazilian State of Minas Gerais where L. (L.) infantum is also endemic. These isolates were characterized in terms of SNPs, chromosome and gene copy number variations, confirming that they are closely related to a previously sequenced isolate obtained in 1973 from the typical Northern range of this species. The results presented in this article will increase our knowledge of L. (L.) amazonensis-specific adaptations to infection, parasite survival and the transmission of this Amazonian species in a new endemic area of Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/26752/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALComparative genomics of canine-isolated Leishmania (Leishmania) .pdfComparative genomics of canine-isolated Leishmania (Leishmania) .pdfapplication/pdf7175997https://www.arca.fiocruz.br/bitstream/icict/26752/2/Comparative%20genomics%20of%20canine-isolated%20Leishmania%20%28Leishmania%29%20.pdfdf50a7e645ae55161fbb0441a4be2436MD52TEXTComparative genomics of canine-isolated Leishmania (Leishmania) .pdf.txtComparative genomics of canine-isolated Leishmania (Leishmania) .pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
title Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
spellingShingle Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
Valdivia, Hugo Oswaldo
Leishmaniose
vetores
Leishmania amazonensis
Leishmaniasis
vectores
Leishmania amazonensis
title_short Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
title_full Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
title_fullStr Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
title_full_unstemmed Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
title_sort Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
author Valdivia, Hugo Oswaldo
author_facet Valdivia, Hugo Oswaldo
Almeida, Laila Vieira
Roatt, Bruno Mendes
Cunha, João Luís Reis
Pereira, Agnes Antônia Sampaio
Gontijo, Celia Maria Ferreira
Fujiwara, Ricardo Toshio
Reis, Alexandre Barbosa
Sanders, Mandy J.
Cotton, James A.
Bartholomeu, Daniella Castanheira
author_role author
author2 Almeida, Laila Vieira
Roatt, Bruno Mendes
Cunha, João Luís Reis
Pereira, Agnes Antônia Sampaio
Gontijo, Celia Maria Ferreira
Fujiwara, Ricardo Toshio
Reis, Alexandre Barbosa
Sanders, Mandy J.
Cotton, James A.
Bartholomeu, Daniella Castanheira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Valdivia, Hugo Oswaldo
Almeida, Laila Vieira
Roatt, Bruno Mendes
Cunha, João Luís Reis
Pereira, Agnes Antônia Sampaio
Gontijo, Celia Maria Ferreira
Fujiwara, Ricardo Toshio
Reis, Alexandre Barbosa
Sanders, Mandy J.
Cotton, James A.
Bartholomeu, Daniella Castanheira
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
vetores
Leishmania amazonensis
topic Leishmaniose
vetores
Leishmania amazonensis
Leishmaniasis
vectores
Leishmania amazonensis
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
vectores
Leishmania amazonensis
description 2020-01-01
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-06-06T18:25:39Z
dc.date.available.fl_str_mv 2018-06-06T18:25:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VALDIVIA, Hugo Oswaldo et al. Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil. Sci Rep., v. 7, 40804, 2017
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26752
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/srep40804
identifier_str_mv VALDIVIA, Hugo Oswaldo et al. Comparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil. Sci Rep., v. 7, 40804, 2017
2045-2322
10.1038/srep40804
url https://www.arca.fiocruz.br/handle/icict/26752
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
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