Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41153 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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Figueiredo, Tiara CascaisTeixeira, Phelipe AustriacoFantinatti, MariaFreitas, Maria Luciana Silva-Oliveira, Joanna Reis SantosCoelho, Camila H.Singer, Steven M.Cruz, Alda Maria da2020-05-07T17:56:32Z2020-05-07T17:56:32Z2020FIGUEIREDO, Tiara Cascais et al. Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil. Pathogens, v. 9, n. 7, 9p, 2020.2076-0817https://www.arca.fiocruz.br/handle/icict/4115310.3390/pathogens90100072076-0817engMDPIGiardia lambliaGiardíaseCriançasCitocinasInterleucina-17Giardia lambliaGiardiasisChildrenI-FABPCytokinesIL-17Giardia assemblagesGiardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia. Núcleo de Ciências Biomédicas Aplicadas. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.National Institutes of Health. National Institutes of Allergy and Infectious Diseases. Laboratory of Malaria Immunology and Vaccinology. Bethesda, MD, USA / Georgetown University. Biology Department. Washington, DC, USA.Georgetown University. Biology Department. Washington, DC, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro . Faculdade de Ciências Mèdicas. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil.Giardiasis is an intestinal infection caused by ingestion of water or food contaminated with cysts of Giardia lamblia. Susceptibility is higher in children and overall prevalence can reach up to 90% in low-income areas, although outbreaks are also reported in developed countries. Both parasite and immune-mediated epithelial damage has been observed in vitro and in animal models. However, whether enterocytes are directly damaged during infection is not entirely known. Our goal was to identify whether plasma levels of intestinal fatty acid binding protein (I-FABP), a marker of enterocyte damage, are related to the immune response in giardiasis. Blood plasma was collected from 31 children (19 Giardia-positive) from a public day care in Rio de Janeiro, Brazil. The levels of I-FABP were increased in Giardia-infected children compared to children without detectable infection. There was no difference in I-FABP levels in giardiasis caused by different genetic assemblages of Giardia. Levels of IL-8 were decreased, while there was a trend to elevated IL-17 in the Giardia-positive children. A positive correlation was observed between I-FABP and IL-17 levels as well as TNF, suggesting that epithelial damage can be related to cytokine production during giardiasis. These results help elucidate the relationship between the disruption of the intestinal mucosal barrier and immune responses to G. lamblia in children.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41153/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdfTiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdfapplication/pdf724534https://www.arca.fiocruz.br/bitstream/icict/41153/2/TiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdf51677c2f87317b2297382a8c628debd9MD52TEXTTiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdf.txtTiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdf.txtExtracted texttext/plain32153https://www.arca.fiocruz.br/bitstream/icict/41153/3/TiaraFigueiredo_AldaMCruz_etal_IOC_2020.pdf.txtff3a6f0c878a302035cf32d56fb4a2d2MD53icict/411532020-05-08 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| dc.title.pt_BR.fl_str_mv |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| title |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| spellingShingle |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil Figueiredo, Tiara Cascais Giardia lamblia Giardíase Crianças Citocinas Interleucina-17 Giardia lamblia Giardiasis Children I-FABP Cytokines IL-17 Giardia assemblages |
| title_short |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| title_full |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| title_fullStr |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| title_full_unstemmed |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| title_sort |
Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil |
| author |
Figueiredo, Tiara Cascais |
| author_facet |
Figueiredo, Tiara Cascais Teixeira, Phelipe Austriaco Fantinatti, Maria Freitas, Maria Luciana Silva- Oliveira, Joanna Reis Santos Coelho, Camila H. Singer, Steven M. Cruz, Alda Maria da |
| author_role |
author |
| author2 |
Teixeira, Phelipe Austriaco Fantinatti, Maria Freitas, Maria Luciana Silva- Oliveira, Joanna Reis Santos Coelho, Camila H. Singer, Steven M. Cruz, Alda Maria da |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Figueiredo, Tiara Cascais Teixeira, Phelipe Austriaco Fantinatti, Maria Freitas, Maria Luciana Silva- Oliveira, Joanna Reis Santos Coelho, Camila H. Singer, Steven M. Cruz, Alda Maria da |
| dc.subject.other.pt_BR.fl_str_mv |
Giardia lamblia Giardíase Crianças Citocinas Interleucina-17 |
| topic |
Giardia lamblia Giardíase Crianças Citocinas Interleucina-17 Giardia lamblia Giardiasis Children I-FABP Cytokines IL-17 Giardia assemblages |
| dc.subject.en.pt_BR.fl_str_mv |
Giardia lamblia Giardiasis Children I-FABP Cytokines IL-17 Giardia assemblages |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-05-07T17:56:32Z |
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2020-05-07T17:56:32Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FIGUEIREDO, Tiara Cascais et al. Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil. Pathogens, v. 9, n. 7, 9p, 2020. |
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https://www.arca.fiocruz.br/handle/icict/41153 |
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2076-0817 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/pathogens9010007 |
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2076-0817 |
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FIGUEIREDO, Tiara Cascais et al. Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil. Pathogens, v. 9, n. 7, 9p, 2020. 2076-0817 10.3390/pathogens9010007 |
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