Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems

Detalhes bibliográficos
Autor(a) principal: Silva, Severino Jefferson Ribeiro da
Data de Publicação: 2020
Outros Autores: Mendes, Renata Pessôa Germano, Silva, Caroline Targino Alves da, Lorusso, Alessio, Kohl, Alain, Pena, Lindomar José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42349
Resumo: FACEPE
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spelling Silva, Severino Jefferson Ribeiro daMendes, Renata Pessôa GermanoSilva, Caroline Targino Alves daLorusso, AlessioKohl, AlainPena, Lindomar José2020-07-22T15:07:04Z2020-07-22T15:07:04Z2020SILVA, Severino Jefferson Ribeiro da et al. Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems. Journal of General Virology, p. 1-4, 24 Jun. 2020.0022-1317https://www.arca.fiocruz.br/handle/icict/4234910.1099/jgv.0.0014581465-2099FACEPECNPqIDRCUK Medical Research Council (MC_UU_12014/8)Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "Giuseppe Caporale". Teramo, Italy.University of Glasgow. Institute of Infection, Immunity & Inflammation. MRC-University of Glasgow Centre for Virus Research. Glasgow, Scotland, UK.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.The emergence and rapid worldwide spread of a novel pandemic of acute respiratory disease – eventually named coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO) – across the human population has raised great concerns. It prompted a mobilization around the globe to study the underlying pathogen, a close relative of severe acute respiratory syndrome coronavirus (SARS-CoV) called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous genome sequences of SARS-CoV-2 are now available and in-depth analyses are advancing. These will allow detailed characterization of sequence and protein functions, including comparative studies. Care should be taken when inferring function from sequence information alone, and reverse genetics systems can be used to unequivocally identify key features. For example, the molecular markers of virulence, host range and transmissibility of SARS-CoV-2 can be compared to those of related viruses in order to shed light on the biology of this emerging pathogen. Here, we summarize some recent insights from genomic studies and strategies for reverse genetics systems to generate recombinant viruses, which will be useful to investigate viral genome properties and evolution.engMicrobiology SocietyInsights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systemsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSARS-CoV-2Reverse geneticsCOVID-19Genomicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en.fl_str_mv Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
title Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
spellingShingle Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
Silva, Severino Jefferson Ribeiro da
SARS-CoV-2
Reverse genetics
COVID-19
Genomics
title_short Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
title_full Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
title_fullStr Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
title_full_unstemmed Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
title_sort Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems
author Silva, Severino Jefferson Ribeiro da
author_facet Silva, Severino Jefferson Ribeiro da
Mendes, Renata Pessôa Germano
Silva, Caroline Targino Alves da
Lorusso, Alessio
Kohl, Alain
Pena, Lindomar José
author_role author
author2 Mendes, Renata Pessôa Germano
Silva, Caroline Targino Alves da
Lorusso, Alessio
Kohl, Alain
Pena, Lindomar José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Severino Jefferson Ribeiro da
Mendes, Renata Pessôa Germano
Silva, Caroline Targino Alves da
Lorusso, Alessio
Kohl, Alain
Pena, Lindomar José
dc.subject.en.en.fl_str_mv SARS-CoV-2
Reverse genetics
COVID-19
Genomics
topic SARS-CoV-2
Reverse genetics
COVID-19
Genomics
description FACEPE
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-22T15:07:04Z
dc.date.available.fl_str_mv 2020-07-22T15:07:04Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Severino Jefferson Ribeiro da et al. Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems. Journal of General Virology, p. 1-4, 24 Jun. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42349
dc.identifier.issn.pt_BR.fl_str_mv 0022-1317
dc.identifier.doi.pt_BR.fl_str_mv 10.1099/jgv.0.001458
dc.identifier.eissn.pt_BR.fl_str_mv 1465-2099
identifier_str_mv SILVA, Severino Jefferson Ribeiro da et al. Insights into SARS-CoV-2, the Coronavirus underlying COVID-19: recent genomic data and the development of reverse genetics systems. Journal of General Virology, p. 1-4, 24 Jun. 2020.
0022-1317
10.1099/jgv.0.001458
1465-2099
url https://www.arca.fiocruz.br/handle/icict/42349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/42349/3/Silva_Severino_etal_IAM_2020_COVID-19.pdf.txt
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