Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23210 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
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Rocha, Sura Wanessa SantosFrança, Maria Eduarda Rocha deRodrigues, Gabriel BarrosBarbosa, Karla Patrícia SousaNunes, Ana Karolina SantanaPastor, André FilipeOliveira, Anne Gabrielle VasconcelosOliveira, Wilma HelenaLuna, Rayana Leal AlmeidaPeixoto, Christina Alves2017-11-16T13:20:48Z2017-11-16T13:20:48Z2014ROCHA, S. W. S. et al. Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators of Inflammation, v. 2014, p. 696383, 2014.1466-1861https://www.arca.fiocruz.br/handle/icict/2321010.1155/2014/696383engAnti-Inflammatory AgentspharmacologyChemical and Drug Induced Liver Injurydrug therapyDiethylcarbamazinepharmacologyCarbon TetrachloridetoxicityAnti-InflamatóriosDoença Hepática Induzida por Substâncias e DrogasDietilcarbamazinaAnimaisInflamaçãoCirrose HepáticaCamundongos Endogâmicos C57BLÓxido NítricoÓxido Nítrico Sintase Tipo IIRNA MensageiroAnti-Inflammatory AgentsChemical and Drug Induced Liver InjuryDiethylcarbamazineAnimalsInflammationLiver CirrhosisDiethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.This study investigated the anti-inflammatory effects of DEC on the CCl4-induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl4 0.5 μL/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days before finishing the CCl4 induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1β, MDA, TGF-β, and αSMA immunopositivity, besides exhibiting decreased IL1β, COX-2, NFκB, IFNγ, and TGFβ expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23210/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. Diethylcarbamazine Reduces - rocha.pdfart. Diethylcarbamazine Reduces - rocha.pdfapplication/pdf5582953https://www.arca.fiocruz.br/bitstream/icict/23210/2/art.%20Diethylcarbamazine%20Reduces%20-%20rocha.pdf562326c09cbcfb6e9d9e7d22e6d0890aMD52TEXTart. Diethylcarbamazine Reduces - rocha.pdf.txtart. 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| dc.title.pt_BR.fl_str_mv |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| title |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| spellingShingle |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice Rocha, Sura Wanessa Santos Anti-Inflammatory Agents pharmacology Chemical and Drug Induced Liver Injury drug therapy Diethylcarbamazine pharmacology Carbon Tetrachloride toxicity Anti-Inflamatórios Doença Hepática Induzida por Substâncias e Drogas Dietilcarbamazina Animais Inflamação Cirrose Hepática Camundongos Endogâmicos C57BL Óxido Nítrico Óxido Nítrico Sintase Tipo II RNA Mensageiro Anti-Inflammatory Agents Chemical and Drug Induced Liver Injury Diethylcarbamazine Animals Inflammation Liver Cirrhosis |
| title_short |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| title_full |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| title_fullStr |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| title_full_unstemmed |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| title_sort |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice |
| author |
Rocha, Sura Wanessa Santos |
| author_facet |
Rocha, Sura Wanessa Santos França, Maria Eduarda Rocha de Rodrigues, Gabriel Barros Barbosa, Karla Patrícia Sousa Nunes, Ana Karolina Santana Pastor, André Filipe Oliveira, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Luna, Rayana Leal Almeida Peixoto, Christina Alves |
| author_role |
author |
| author2 |
França, Maria Eduarda Rocha de Rodrigues, Gabriel Barros Barbosa, Karla Patrícia Sousa Nunes, Ana Karolina Santana Pastor, André Filipe Oliveira, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Luna, Rayana Leal Almeida Peixoto, Christina Alves |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Sura Wanessa Santos França, Maria Eduarda Rocha de Rodrigues, Gabriel Barros Barbosa, Karla Patrícia Sousa Nunes, Ana Karolina Santana Pastor, André Filipe Oliveira, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Luna, Rayana Leal Almeida Peixoto, Christina Alves |
| dc.subject.mesh.pt_BR.fl_str_mv |
Anti-Inflammatory Agents pharmacology Chemical and Drug Induced Liver Injury drug therapy Diethylcarbamazine pharmacology Carbon Tetrachloride toxicity |
| topic |
Anti-Inflammatory Agents pharmacology Chemical and Drug Induced Liver Injury drug therapy Diethylcarbamazine pharmacology Carbon Tetrachloride toxicity Anti-Inflamatórios Doença Hepática Induzida por Substâncias e Drogas Dietilcarbamazina Animais Inflamação Cirrose Hepática Camundongos Endogâmicos C57BL Óxido Nítrico Óxido Nítrico Sintase Tipo II RNA Mensageiro Anti-Inflammatory Agents Chemical and Drug Induced Liver Injury Diethylcarbamazine Animals Inflammation Liver Cirrhosis |
| dc.subject.other.pt_BR.fl_str_mv |
Anti-Inflamatórios Doença Hepática Induzida por Substâncias e Drogas Dietilcarbamazina Animais Inflamação Cirrose Hepática Camundongos Endogâmicos C57BL Óxido Nítrico Óxido Nítrico Sintase Tipo II RNA Mensageiro |
| dc.subject.en.pt_BR.fl_str_mv |
Anti-Inflammatory Agents Chemical and Drug Induced Liver Injury Diethylcarbamazine Animals Inflammation Liver Cirrhosis |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
| publishDate |
2014 |
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2014 |
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2017-11-16T13:20:48Z |
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2017-11-16T13:20:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ROCHA, S. W. S. et al. Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators of Inflammation, v. 2014, p. 696383, 2014. |
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https://www.arca.fiocruz.br/handle/icict/23210 |
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1466-1861 |
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10.1155/2014/696383 |
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ROCHA, S. W. S. et al. Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators of Inflammation, v. 2014, p. 696383, 2014. 1466-1861 10.1155/2014/696383 |
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