Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.

Detalhes bibliográficos
Autor(a) principal: Magalhães, Juracy Barbosa
Data de Publicação: 1994
Outros Autores: Andrade, Sonia Gumes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5699
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Magalhães, Juracy BarbosaAndrade, Sonia Gumes2012-10-19T20:57:51Z2012-10-19T20:57:51Z1994MAGALHÃES, J.B.; ANDRADE, S.G. Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de São Paulo, v. 36, p. 6, p. 481-4, nov.-dec. 1994.0036-4665https://www.arca.fiocruz.br/handle/icict/5699engInvestigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSeventy Swiss mice chronically infected with different strains of Trypanosoma cruzi, with persistently negative parasitemia on routine blood examination were parasitologically investigated to find out whether spontaneous cure occurred. Duration of infection varied from 90 to 250 days in the initial phase of this investigation. Parasitological tests consisted of daily direct blood examination performed during at least 25 days, followed by xenodiagnosis and subinoculation of blood into newborn mice. Mice that persisted negative were treated with Cyclophosphamide with one dose of 250 mg/kg of body weight and then investigated by direct blood examination, xenodiagnosis and subinoculation. A second dose of 250 mg/kg b. w. was given to the persistently negative mice. With one single exception, all mice showed positive parasitological tests in the different stages of the present investigation and we conclude that spontaneous cure did not occur in this group, which is representative of the chronic infection with different strains of T. cruzi.Trypanosoma cruziSpontaneous cureChronic infectionMurine modelCyclophosphamideDoença de Chagas/parasitologiaAnimaisDoença de Chagas /diagnósticoDoença de Chagas /quimioterapiaDoença CrônicaCiclofosfamida/administração & dosagemCiclofosfamida/uso terapêuticoCamundongosRemissão EspontâneaFatores de TempoTrypanosoma cruzi/efeitos de drogasTrypanosoma cruzi/isolamento & purificaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMagalhaes JB Investigation on the possibility....pdfMagalhaes JB Investigation on the possibility....pdfapplication/pdf236049https://www.arca.fiocruz.br/bitstream/icict/5699/1/Magalhaes%20JB%20Investigation%20on%20the%20possibility....pdf60b3a1c6a780a7c2b85b1810871dd325MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5699/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTMagalhaes JB Investigation on the possibility....pdf.txtMagalhaes JB Investigation on the possibility....pdf.txtExtracted texttext/plain4https://www.arca.fiocruz.br/bitstream/icict/5699/5/Magalhaes%20JB%20Investigation%20on%20the%20possibility....pdf.txtff4c8ff01d544500ea4bfea43e6108c1MD55THUMBNAILMagalhaes JB Investigation on the possibility....pdf.jpgMagalhaes JB Investigation on the possibility....pdf.jpgGenerated Thumbnailimage/jpeg1688https://www.arca.fiocruz.br/bitstream/icict/5699/4/Magalhaes%20JB%20Investigation%20on%20the%20possibility....pdf.jpga018af76ccd7b3c13c5c1042088abe9dMD54icict/56992023-03-15 14:32:56.558oai:www.arca.fiocruz.br:icict/5699TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
title Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
spellingShingle Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
Magalhães, Juracy Barbosa
Trypanosoma cruzi
Spontaneous cure
Chronic infection
Murine model
Cyclophosphamide
Doença de Chagas/parasitologia
Animais
Doença de Chagas /diagnóstico
Doença de Chagas /quimioterapia
Doença Crônica
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Camundongos
Remissão Espontânea
Fatores de Tempo
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/isolamento & purificação
title_short Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
title_full Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
title_fullStr Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
title_full_unstemmed Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
title_sort Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi.
author Magalhães, Juracy Barbosa
author_facet Magalhães, Juracy Barbosa
Andrade, Sonia Gumes
author_role author
author2 Andrade, Sonia Gumes
author2_role author
dc.contributor.author.fl_str_mv Magalhães, Juracy Barbosa
Andrade, Sonia Gumes
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Spontaneous cure
Chronic infection
Murine model
Cyclophosphamide
topic Trypanosoma cruzi
Spontaneous cure
Chronic infection
Murine model
Cyclophosphamide
Doença de Chagas/parasitologia
Animais
Doença de Chagas /diagnóstico
Doença de Chagas /quimioterapia
Doença Crônica
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Camundongos
Remissão Espontânea
Fatores de Tempo
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/isolamento & purificação
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas/parasitologia
Animais
Doença de Chagas /diagnóstico
Doença de Chagas /quimioterapia
Doença Crônica
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Camundongos
Remissão Espontânea
Fatores de Tempo
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/isolamento & purificação
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2012-10-19T20:57:51Z
dc.date.available.fl_str_mv 2012-10-19T20:57:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MAGALHÃES, J.B.; ANDRADE, S.G. Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de São Paulo, v. 36, p. 6, p. 481-4, nov.-dec. 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5699
dc.identifier.issn.none.fl_str_mv 0036-4665
identifier_str_mv MAGALHÃES, J.B.; ANDRADE, S.G. Investigation on the possibility of spontaneous cure of mice infected with different strains of Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de São Paulo, v. 36, p. 6, p. 481-4, nov.-dec. 1994.
0036-4665
url https://www.arca.fiocruz.br/handle/icict/5699
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