An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1993 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3256 |
Resumo: | Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil |
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Brener, ZigmanCançado, Joaquim RomeuGalvão, Lúcia Maria da CunhaLuz, Zélia Maria Profeta daFilardi, Leny de SouzaPereira, Maria Elisabeth SoaresSantos, Luiz Mauro T.Cançado, Catarina B.2011-10-08T23:28:45Z2011-10-08T23:28:45Z1993BRENER, Zigman et al. An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Memórias do Instituto Oswaldo Cruz, v.88, n.1, p. 149-153, 1993.https://www.arca.fiocruz.br/handle/icict/3256engFundação Oswaldo CruzAn Experimental and clinical assay with ketoconazole in the treatment of Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina.Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilCentro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilKetoconazole, an azole antifungic drug wich is already in the market has also been demonstrated to be active against Trypanosoma Cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity different T.cruzi strains naturally resistant or susceptible to both standard drugs Nifurtimox and Benznidazole plus Lovastatin (an inhibitor of sterol synthesis), wich has an antiproliferative effect against T. cruzi in vitro, failed to enhance the suppressive of Ketoconazole displayed when administered alone to infected mice. Finally, administration in chronic chagasic patients of Ketoconazole at doses used in the treatment of deep mycosis also failed to induce cure as demonstrated by parasitological and serological tests. The strategy of identify and test drugs wich are already in the market and fortuitously are active against T.cruzi has been discussed.Trypanosoma cruziChagas diseaseKetoconazoleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAn_Experimental_and_clinical.pdfAn_Experimental_and_clinical.pdfapplication/pdf290648https://www.arca.fiocruz.br/bitstream/icict/3256/1/An_Experimental_and_clinical.pdf35214aa0012d632242bbec78f1beefa1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3256/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAn_Experimental_and_clinical.pdf.txtAn_Experimental_and_clinical.pdf.txtExtracted texttext/plain5https://www.arca.fiocruz.br/bitstream/icict/3256/5/An_Experimental_and_clinical.pdf.txtcc9067c2ee470dc248b14b194209a34eMD55THUMBNAILAn_Experimental_and_clinical.pdf.jpgAn_Experimental_and_clinical.pdf.jpgGenerated Thumbnailimage/jpeg2451https://www.arca.fiocruz.br/bitstream/icict/3256/4/An_Experimental_and_clinical.pdf.jpgebce58b17d6016dcd03c10af3e0164c7MD54icict/32562018-04-25 14:10:32.865oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-25T17:10:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| title |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| spellingShingle |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease Brener, Zigman Trypanosoma cruzi Chagas disease Ketoconazole |
| title_short |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| title_full |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| title_fullStr |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| title_full_unstemmed |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| title_sort |
An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease |
| author |
Brener, Zigman |
| author_facet |
Brener, Zigman Cançado, Joaquim Romeu Galvão, Lúcia Maria da Cunha Luz, Zélia Maria Profeta da Filardi, Leny de Souza Pereira, Maria Elisabeth Soares Santos, Luiz Mauro T. Cançado, Catarina B. |
| author_role |
author |
| author2 |
Cançado, Joaquim Romeu Galvão, Lúcia Maria da Cunha Luz, Zélia Maria Profeta da Filardi, Leny de Souza Pereira, Maria Elisabeth Soares Santos, Luiz Mauro T. Cançado, Catarina B. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brener, Zigman Cançado, Joaquim Romeu Galvão, Lúcia Maria da Cunha Luz, Zélia Maria Profeta da Filardi, Leny de Souza Pereira, Maria Elisabeth Soares Santos, Luiz Mauro T. Cançado, Catarina B. |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease Ketoconazole |
| topic |
Trypanosoma cruzi Chagas disease Ketoconazole |
| description |
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil |
| publishDate |
1993 |
| dc.date.issued.fl_str_mv |
1993 |
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2011-10-08T23:28:45Z |
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2011-10-08T23:28:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BRENER, Zigman et al. An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Memórias do Instituto Oswaldo Cruz, v.88, n.1, p. 149-153, 1993. |
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https://www.arca.fiocruz.br/handle/icict/3256 |
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BRENER, Zigman et al. An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Memórias do Instituto Oswaldo Cruz, v.88, n.1, p. 149-153, 1993. |
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