In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals

Detalhes bibliográficos
Autor(a) principal: Chaves, Thiago Santos
Data de Publicação: 2019
Outros Autores: Chaves, Beatriz, Conte, Fernando de Paiva, Silva, Rodrigo Nunes Rodrigues da, Neves, Patrícia Cristina da Costa
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32699
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Chaves, Thiago SantosChaves, BeatrizConte, Fernando de PaivaSilva, Rodrigo Nunes Rodrigues daNeves, Patrícia Cristina da Costa2019-04-24T13:08:43Z2019-04-24T13:08:43Z2019CHAVES, T. S. et al. In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 97.https://www.arca.fiocruz.br/handle/icict/3269910.35259/isi.sact.2019_32699Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosCâncerAnticorpo monoclonalBioinformáticaCancerMonoclonal antibodyBioinformaticsNeoplasiasAnticorpos MonoclonaisBiologia ComputacionalIn silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticalsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32699/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALBIO_12.pdfapplication/pdf58778https://www.arca.fiocruz.br/bitstream/icict/32699/2/BIO_12.pdff9a05a13f3b14eb6b25e6fb62cf0150aMD52TEXTBIO_12.pdf.txtBIO_12.pdf.txtExtracted texttext/plain3757https://www.arca.fiocruz.br/bitstream/icict/32699/3/BIO_12.pdf.txtdda724c566d29fd78554caca1609f0aeMD53icict/326992023-04-26 17:00:49.251oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T20:00:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
title In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
spellingShingle In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
Chaves, Thiago Santos
Câncer
Anticorpo monoclonal
Bioinformática
Cancer
Monoclonal antibody
Bioinformatics
Neoplasias
Anticorpos Monoclonais
Biologia Computacional
title_short In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
title_full In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
title_fullStr In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
title_full_unstemmed In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
title_sort In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
author Chaves, Thiago Santos
author_facet Chaves, Thiago Santos
Chaves, Beatriz
Conte, Fernando de Paiva
Silva, Rodrigo Nunes Rodrigues da
Neves, Patrícia Cristina da Costa
author_role author
author2 Chaves, Beatriz
Conte, Fernando de Paiva
Silva, Rodrigo Nunes Rodrigues da
Neves, Patrícia Cristina da Costa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Chaves, Thiago Santos
Chaves, Beatriz
Conte, Fernando de Paiva
Silva, Rodrigo Nunes Rodrigues da
Neves, Patrícia Cristina da Costa
dc.subject.other.pt_BR.fl_str_mv Câncer
Anticorpo monoclonal
Bioinformática
topic Câncer
Anticorpo monoclonal
Bioinformática
Cancer
Monoclonal antibody
Bioinformatics
Neoplasias
Anticorpos Monoclonais
Biologia Computacional
dc.subject.en.pt_BR.fl_str_mv Cancer
Monoclonal antibody
Bioinformatics
dc.subject.decs.pt_BR.fl_str_mv Neoplasias
Anticorpos Monoclonais
Biologia Computacional
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-04-24T13:08:43Z
dc.date.available.fl_str_mv 2019-04-24T13:08:43Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAVES, T. S. et al. In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 97.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32699
dc.identifier.doi.none.fl_str_mv 10.35259/isi.sact.2019_32699
identifier_str_mv CHAVES, T. S. et al. In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 97.
10.35259/isi.sact.2019_32699
url https://www.arca.fiocruz.br/handle/icict/32699
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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