Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Silva, Mayara Calixto da
Data de Publicação: 2023
Outros Autores: Oliveira, Rogério Adas Ayres de, Vasconcellos, Ana Claudia Santiago de, Rebouças, Bruno Hojo, Pinto, Bruna Duarte, Lima, Marcelo de Oliveira, Jesus, Iracina Maura de, Machado, Daniel Escorsim, Hacon, Sandra Souza, Basta, Paulo Cesar, Perini, Jamila Alessandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59867
Resumo: State University of Rio de Janeiro. Research Laboratory of Pharmaceutical Sciences. Rio de Janeiro, RJ, Brazil / Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Program of Post-Graduation in Public Health and Environment. Rio de Janeiro, RJ, Brazil.
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spelling Silva, Mayara Calixto daOliveira, Rogério Adas Ayres deVasconcellos, Ana Claudia Santiago deRebouças, Bruno HojoPinto, Bruna DuarteLima, Marcelo de OliveiraJesus, Iracina Maura deMachado, Daniel EscorsimHacon, Sandra SouzaBasta, Paulo CesarPerini, Jamila Alessandra2023-08-01T17:04:08Z2023-08-01T17:04:08Z2023SILVA, Mayara Calixto da et al. Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon. Toxics, v. 11, n. 138, p. 1-13, Jan. 2023.2305-6304https://www.arca.fiocruz.br/handle/icict/5986710.3390/toxics110201382305-6304engMDPIChronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleState University of Rio de Janeiro. Research Laboratory of Pharmaceutical Sciences. Rio de Janeiro, RJ, Brazil / Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Program of Post-Graduation in Public Health and Environment. Rio de Janeiro, RJ, Brazil.University of São Paulo. Faculty of Medicine. São Paulo, SP, Brazil.Oswald Cruz Foundation. Polytechnic School of Health Joaquim Venâncio. Laboratory of Professional Education in Health Surveillance. Rio de Janeiro, RJ, Brazil.University of São Paulo. Faculty of Medicine. São Paulo, SP, Brazil.University of São Paulo. Faculty of Medicine. São Paulo, SP, Brazil.Ministry of Health. Health Surveillance Secretariat. Oswald Cruz Foundation. Evandro Chagas Institute. Environment Section. Ananindeua, PA, Brazil.Ministry of Health. Health Surveillance Secretariat. Oswald Cruz Foundation. Evandro Chagas Institute. Environment Section. Ananindeua, PA, Brazil.State University of Rio de Janeiro. Research Laboratory of Pharmaceutical Sciences. Rio de Janeiro, RJ, Brazil.Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Department of Endemic Diseases Samuel Pessoa. Rio de Janeiro, RJ, Brazil.Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Program of Post-Graduation in Public Health and Environment. Rio de Janeiro, RJ, Brazil / Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Department of Endemic Diseases Samuel Pessoa. Rio de Janeiro, RJ, Brazil.State University of Rio de Janeiro. Research Laboratory of Pharmaceutical Sciences. Rio de Janeiro, RJ, Brazil.Genetic polymorphisms may be involved with mercury levels and signs and symptoms of intoxication from this exposure. Therefore, the aims were to describe the frequency of the GSTP1 polymorphism and to evaluate its effects on mercury levels and neurological signs in three Munduruku indigenous villages in the Brazilian Amazon. One-hundred-and-seven indigenous (over 12 years old) were included and genotyped (rs1695) using a TaqMan validated assay. Then, associations were evaluated by binary logistic regression, using odds ratios (OR) and 95% confidence intervals (CI). Mean age was 27.4 ± 13.9 years old, 52.3% were male, mean hair mercury concentration was 8.5 ± 4.3, exceeding the reference limit (≥6.0 µg/g), and were different among the three villages: 13.5 ± 4.6 µg/g in Sawré Aboy, 7.4 ± 2.3 µg/g in Poxo Muybu and 6.9 ± 3.5 µg/g in Sawré Muybu. The minor allele frequency of GSTP1 G was significantly different among the villages: 57% Sawré Muybu, 21% Poxo Muybu and 15% Sawré Aboy. Finally, after adjustment, GSTP1 GG and GA genotypes were associated with lower levels of Hg (OR = 0.13; CI95% = 0.03–0.49) and abnormal somatosensory signs (OR = 3.7; 95%IC = 1.5–9.3), respectively. In conclusion, monitoring this population is imperative to identify individuals at higher risk of developing signs of chronic mercury exposure based on the genetic profile.Mercury ExposureGSTP1Genetic PolymorphismNeurotoxicityEnvironmental HealthIndigenous PeopleBrazilian Amazoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59867/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Mayara_Silva_etal_ENSP_2023.pdfve_Mayara_Silva_etal_ENSP_2023.pdfapplication/pdf656839https://www.arca.fiocruz.br/bitstream/icict/59867/2/ve_Mayara_Silva_etal_ENSP_2023.pdfabc34e0676d498bbed52c2676d4268f9MD52icict/598672023-09-05 22:24:29.707oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
title Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
spellingShingle Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
Silva, Mayara Calixto da
Mercury Exposure
GSTP1
Genetic Polymorphism
Neurotoxicity
Environmental Health
Indigenous People
Brazilian Amazon
title_short Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
title_full Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
title_fullStr Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
title_full_unstemmed Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
title_sort Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon
author Silva, Mayara Calixto da
author_facet Silva, Mayara Calixto da
Oliveira, Rogério Adas Ayres de
Vasconcellos, Ana Claudia Santiago de
Rebouças, Bruno Hojo
Pinto, Bruna Duarte
Lima, Marcelo de Oliveira
Jesus, Iracina Maura de
Machado, Daniel Escorsim
Hacon, Sandra Souza
Basta, Paulo Cesar
Perini, Jamila Alessandra
author_role author
author2 Oliveira, Rogério Adas Ayres de
Vasconcellos, Ana Claudia Santiago de
Rebouças, Bruno Hojo
Pinto, Bruna Duarte
Lima, Marcelo de Oliveira
Jesus, Iracina Maura de
Machado, Daniel Escorsim
Hacon, Sandra Souza
Basta, Paulo Cesar
Perini, Jamila Alessandra
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Mayara Calixto da
Oliveira, Rogério Adas Ayres de
Vasconcellos, Ana Claudia Santiago de
Rebouças, Bruno Hojo
Pinto, Bruna Duarte
Lima, Marcelo de Oliveira
Jesus, Iracina Maura de
Machado, Daniel Escorsim
Hacon, Sandra Souza
Basta, Paulo Cesar
Perini, Jamila Alessandra
dc.subject.en.en_US.fl_str_mv Mercury Exposure
GSTP1
Genetic Polymorphism
Neurotoxicity
Environmental Health
Indigenous People
Brazilian Amazon
topic Mercury Exposure
GSTP1
Genetic Polymorphism
Neurotoxicity
Environmental Health
Indigenous People
Brazilian Amazon
description State University of Rio de Janeiro. Research Laboratory of Pharmaceutical Sciences. Rio de Janeiro, RJ, Brazil / Oswald Cruz Foundation. National School of Public Health Sergio Arouca. Program of Post-Graduation in Public Health and Environment. Rio de Janeiro, RJ, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-01T17:04:08Z
dc.date.available.fl_str_mv 2023-08-01T17:04:08Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Mayara Calixto da et al. Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon. Toxics, v. 11, n. 138, p. 1-13, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59867
dc.identifier.issn.none.fl_str_mv 2305-6304
dc.identifier.doi.none.fl_str_mv 10.3390/toxics11020138
dc.identifier.eissn.none.fl_str_mv 2305-6304
identifier_str_mv SILVA, Mayara Calixto da et al. Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon. Toxics, v. 11, n. 138, p. 1-13, Jan. 2023.
2305-6304
10.3390/toxics11020138
url https://www.arca.fiocruz.br/handle/icict/59867
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59867/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59867/2/ve_Mayara_Silva_etal_ENSP_2023.pdf
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