Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Cifuentes-González, Carlos
Data de Publicação: 2023
Outros Autores: Rojas-Carabali, William, Pérez, Álvaro Olate, Carvalho, Érika, Valenzuela, Felipe, Miguel-Escuder, Lucía, Ormaechea, María Soledad, Heredia, Milagros, Baquero-Ospina, Pablo, Adan, Alfredo, Curi, Andre, Schlaen, Ariel, Alejandro Urzua, Cristhian, Couto, Cristóbal, Arellanes, Lourdes, de-la-Torre, Alejandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58875
Resumo: Neuroscience Research Group. Neurovitae Center for Neuroscience. Institute of Translational Medicine. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia.
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spelling Cifuentes-González, CarlosRojas-Carabali, WilliamPérez, Álvaro OlateCarvalho, ÉrikaValenzuela, FelipeMiguel-Escuder, LucíaOrmaechea, María SoledadHeredia, MilagrosBaquero-Ospina, PabloAdan, AlfredoCuri, AndreSchlaen, ArielAlejandro Urzua, CristhianCouto, CristóbalArellanes, Lourdesde-la-Torre, Alejandra2023-06-02T02:18:20Z2023-06-02T02:18:20Z2023CIFUENTES-GONZÁLEZ, Carlos et al. Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis. PLoS One, v. 18, n. 4, p. 1-31, Apr. 2023.1932-6203https://www.arca.fiocruz.br/handle/icict/5887510.1371/journal.pone.02838451932-6203engPublic Library of ScienceRisk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNeuroscience Research Group. Neurovitae Center for Neuroscience. Institute of Translational Medicine. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia.Neuroscience Research Group. Neurovitae Center for Neuroscience. Institute of Translational Medicine. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia.Laboratory of Ocular and Systemic Autoimmune Diseases. Faculty of Medicine. University of Chile. Santiago, Chile.Oswaldo Cruz Foundation. National Institute of Infectious Disease. Clinical Research Laboratory of Infectious Diseases in Ophthalmogy. Rio de Janeiro, RJ, Brazil.Laboratory of Ocular and Systemic Autoimmune Diseases. Faculty of Medicine. University of Chile. Santiago, Chile.Hospital Clinic of Barcelona. Clinic Institute of Ophthalmology. University of Barcelona. Barcelona, Spain.Department of Ophthalmology. Hospital de Clinicas Jose de San Martin. Universidad de Buenos Aires. Buenos Aires City, Argentina / Department of Ophthalmology. Hospital Universitario Austral. Buenos Aires, Argentina.Department of Ophthalmology. Hospital de Clinicas Jose de San Martin. Universidad de Buenos Aires. Buenos Aires City, Argentina / Department of Ophthalmology. Hospital Universitario Austral. Buenos Aires, Argentina.Inflammatory Eye Disease Clinic, Dr. Luis Sanchez Bulnes" Hospital. Asociación para Evitar la Ceguera en México. Mexico City, Mexico.Hospital Clinic of Barcelona. Clinic Institute of Ophthalmology. University of Barcelona. Barcelona, Spain / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Oswaldo Cruz Foundation. National Institute of Infectious Disease. Clinical Research Laboratory of Infectious Diseases in Ophthalmogy. Rio de Janeiro, RJ, Brazil / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Department of Ophthalmology. Hospital de Clinicas Jose de San Martin. Universidad de Buenos Aires. Buenos Aires City, Argentina / Department of Ophthalmology. Hospital Universitario Austral. Buenos Aires, Argentina / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Laboratory of Ocular and Systemic Autoimmune Diseases. Faculty of Medicine. University of Chile. Santiago, Chile / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT) / Faculty of Medicine. Clinica Alemana-Universidad del Desarrollo. Santiago, Chile.Department of Ophthalmology. Hospital de Clinicas Jose de San Martin. Universidad de Buenos Aires. Buenos Aires City, Argentina / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Inflammatory Eye Disease Clinic, Dr. Luis Sanchez Bulnes" Hospital. Asociación para Evitar la Ceguera en México. Mexico City, Mexico / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Neuroscience Research Group. Neurovitae Center for Neuroscience. Institute of Translational Medicine. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia / Red de Investigación en Inmunología Ocular de Latinoamérica (RIOLAT).Background: Ocular toxoplasmosis (OT) is caused by the parasite Toxoplasma gondii. OT is the leading cause of posterior uveitis globally; it is a recurrent disease that may result in visual impairment and blindness. This systematic review and meta-analysis aim to summarize and evaluate the risk factors for recurrences, visual impairment, and blindness described in the literature worldwide. Methods and findings: We performed a systematic literature search in PubMed, Embase, VHL, Cochrane Library, Scopus, and DANS EASY Archive. All studies reporting patients with clinically and serologically confirmed OT presenting any clinical or paraclinical factor influencing recurrences, visual impairment, and blindness were included. Studies presenting secondary data, case reports, and case series were excluded. An initial selection was made by title and abstract, and then the studies were reviewed by full text where the eligible studies were selected. Then, the risk of bias was assessed through validated tools. Data were extracted using a validated extraction format. Qualitative synthesis and quantitative analysis were done. This study was registered on PROSPERO (CRD42022327836). Results: Seventy two studies met the inclusion criteria. Fifty-three were summarized in the qualitative synthesis in three sections: clinical and environmental factors, parasite and host factors, and treatment-related factors. Of the 72 articles, 39 were included in the meta-analysis, of which 14 were conducted in South America, 13 in Europe, four in Asia, three multinational, two in North America and Central America, respectively, and only one in Africa. A total of 4,200 patients with OT were analyzed, mean age ranged from 7.3 to 65.1 year of age, with similar distribution by sex. The frequency of recurrences in patients with OT was 49% (95% CI 40%-58%), being more frequent in the South American population than in Europeans. Additionally, visual impairment was presented in 35% (95% CI 25%-48%) and blindness in 20% (95% CI 13%-30%) of eyes, with a similar predominance in South Americans than in Europeans. On the other hand, having lesions near the macula or adjacent to the optic nerve had an OR of 4.83 (95% CI; 2.72-8.59) for blindness, similar to having more than one recurrence that had an OR of 3.18 (95% CI; 1.59-6.38). Finally, the prophylactic therapy with Trimethoprim/Sulfamethoxazole versus the placebo showed a protective factor of 83% during the first year and 87% in the second year after treatment. Conclusion: Our Systematic Review showed that clinical factors such as being older than 40 years, patients with de novo OT lesions or with less than one year after the first episode, macular area involvement, lesions greater than 1 disc diameter, congenital toxoplasmosis, and bilateral compromise had more risk of recurrences. Also, environmental and parasite factors such as precipitations, geographical region where the infection is acquired, and more virulent strains confer greater risk of recurrences. Therefore, patients with the above mentioned clinical, environmental, and parasite factors could benefit from using prophylactic therapy.Ocular toxoplasmosis (OT)ParasiteToxoplasma gondiiSystematic ReviewRisk of recurrencesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58875/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Carlos_Cifuentes-González_etal_INI_2023.pdfve_Carlos_Cifuentes-González_etal_INI_2023.pdfapplication/pdf3425221https://www.arca.fiocruz.br/bitstream/icict/58875/2/ve_Carlos_Cifuentes-Gonz%c3%a1lez_etal_INI_2023.pdfa6a0bfa14535774a7ab33e13d551f3bdMD52icict/588752023-06-01 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dc.title.en_US.fl_str_mv Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
title Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
spellingShingle Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
Cifuentes-González, Carlos
Ocular toxoplasmosis (OT)
Parasite
Toxoplasma gondii
Systematic Review
Risk of recurrences
title_short Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
title_full Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
title_fullStr Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
title_full_unstemmed Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
title_sort Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis
author Cifuentes-González, Carlos
author_facet Cifuentes-González, Carlos
Rojas-Carabali, William
Pérez, Álvaro Olate
Carvalho, Érika
Valenzuela, Felipe
Miguel-Escuder, Lucía
Ormaechea, María Soledad
Heredia, Milagros
Baquero-Ospina, Pablo
Adan, Alfredo
Curi, Andre
Schlaen, Ariel
Alejandro Urzua, Cristhian
Couto, Cristóbal
Arellanes, Lourdes
de-la-Torre, Alejandra
author_role author
author2 Rojas-Carabali, William
Pérez, Álvaro Olate
Carvalho, Érika
Valenzuela, Felipe
Miguel-Escuder, Lucía
Ormaechea, María Soledad
Heredia, Milagros
Baquero-Ospina, Pablo
Adan, Alfredo
Curi, Andre
Schlaen, Ariel
Alejandro Urzua, Cristhian
Couto, Cristóbal
Arellanes, Lourdes
de-la-Torre, Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cifuentes-González, Carlos
Rojas-Carabali, William
Pérez, Álvaro Olate
Carvalho, Érika
Valenzuela, Felipe
Miguel-Escuder, Lucía
Ormaechea, María Soledad
Heredia, Milagros
Baquero-Ospina, Pablo
Adan, Alfredo
Curi, Andre
Schlaen, Ariel
Alejandro Urzua, Cristhian
Couto, Cristóbal
Arellanes, Lourdes
de-la-Torre, Alejandra
dc.subject.en.en_US.fl_str_mv Ocular toxoplasmosis (OT)
Parasite
Toxoplasma gondii
Systematic Review
Risk of recurrences
topic Ocular toxoplasmosis (OT)
Parasite
Toxoplasma gondii
Systematic Review
Risk of recurrences
description Neuroscience Research Group. Neurovitae Center for Neuroscience. Institute of Translational Medicine. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá, Colombia.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-02T02:18:20Z
dc.date.available.fl_str_mv 2023-06-02T02:18:20Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CIFUENTES-GONZÁLEZ, Carlos et al. Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis. PLoS One, v. 18, n. 4, p. 1-31, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58875
dc.identifier.issn.en_US.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0283845
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv CIFUENTES-GONZÁLEZ, Carlos et al. Risk factors for recurrences and visual impairment in patients with ocular toxoplasmosis: A systematic review and meta-analysis. PLoS One, v. 18, n. 4, p. 1-31, Apr. 2023.
1932-6203
10.1371/journal.pone.0283845
url https://www.arca.fiocruz.br/handle/icict/58875
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58875/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58875/2/ve_Carlos_Cifuentes-Gonz%c3%a1lez_etal_INI_2023.pdf
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