Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus

Detalhes bibliográficos
Autor(a) principal: León, Fabiola Justina Fumero
Data de Publicação: 2022
Outros Autores: Silva, Lucas Lima da, Santos, Alanna Calheiros, Costa, Vanessa Duarte da, Miguel, Juliana Custódio, Marques, Julia Trece, Nascimento, Giselle Prado, Silva, Elisangela Ferreira da, Lewis‐Ximenez, Lia Laura, Villar, Livia Melo, Paula, Vanessa Salete de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53559
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling León, Fabiola Justina FumeroSilva, Lucas Lima daSantos, Alanna CalheirosCosta, Vanessa Duarte daMiguel, Juliana CustódioMarques, Julia TreceNascimento, Giselle PradoSilva, Elisangela Ferreira daLewis‐Ximenez, Lia LauraVillar, Livia MeloPaula, Vanessa Salete de2022-06-28T17:29:17Z2022-06-28T17:29:17Z2022LEÓN, Fabiola Justina Fumero et al. Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus. Journal of Medical Virology, v. 94, p. 2296-2301, 2022.1096-9071https://www.arca.fiocruz.br/handle/icict/5355910.1002/jmv.27614engWileyCOVID-19CitocinasHepatiteIL‐6IL‐17TNF‐αCOVID-19CytokinesHepatitisIL‐6IL‐17TNF‐αImmunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection can generate a systemic inflammatory response, characterized by a cytokine storm and associated with an exaggerated release of proinflammatory cytokines, including tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and IL‐17, all of which can affect the liver. Here, we aimed to evaluate the cytokine profiles of patients suffering from coronavirus disease (COVID)‐19 and/or hepatitis. We subjected 87 patients to serology and/or polymerase chain reaction analysis for the hepatitis C virus. They were also tested for TNF‐α, IL‐6, and IL‐17 using commercial immunoassay kits. The test results of the COVID‐19/hepatitis C patients (n = 8) were compared with that of the negative controls (n = 28), hepatitis C patients (n = 29), and COVID‐19 patients (n = 22). All COVID‐19 patients (mono‐ and coinfected) expressed high levels of cytokines. The COVID‐19/hepatitis patients exhibited higher levels of IL‐6 (6.33 ± 3.9 pg/ml) and IL‐17 (102.23 ± 2.7 pg/ml); however, TNF‐α values were lower (68.08 ± 15.88 pg/ml), as compared with that of the hepatitis patients (p < 0.001), and lower than that of the COVID‐19 patients and exceptionally for TNF‐α (p < 0.05). These data highlight the importance of monitoring patients with hepatitis and COVID‐19.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53559/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFabiolaLeon_LiviaMVilar_etal_IOC_2022.pdfFabiolaLeon_LiviaMVilar_etal_IOC_2022.pdfapplication/pdf792452https://www.arca.fiocruz.br/bitstream/icict/53559/2/FabiolaLeon_LiviaMVilar_etal_IOC_2022.pdf172c8d867ba817eca3fe17deb77b470bMD52icict/535592022-07-10 00:01:16.84oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-07-10T03:01:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
title Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
spellingShingle Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
León, Fabiola Justina Fumero
COVID-19
Citocinas
Hepatite
IL‐6
IL‐17
TNF‐α
COVID-19
Cytokines
Hepatitis
IL‐6
IL‐17
TNF‐α
title_short Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
title_full Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
title_fullStr Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
title_full_unstemmed Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
title_sort Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus
author León, Fabiola Justina Fumero
author_facet León, Fabiola Justina Fumero
Silva, Lucas Lima da
Santos, Alanna Calheiros
Costa, Vanessa Duarte da
Miguel, Juliana Custódio
Marques, Julia Trece
Nascimento, Giselle Prado
Silva, Elisangela Ferreira da
Lewis‐Ximenez, Lia Laura
Villar, Livia Melo
Paula, Vanessa Salete de
author_role author
author2 Silva, Lucas Lima da
Santos, Alanna Calheiros
Costa, Vanessa Duarte da
Miguel, Juliana Custódio
Marques, Julia Trece
Nascimento, Giselle Prado
Silva, Elisangela Ferreira da
Lewis‐Ximenez, Lia Laura
Villar, Livia Melo
Paula, Vanessa Salete de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv León, Fabiola Justina Fumero
Silva, Lucas Lima da
Santos, Alanna Calheiros
Costa, Vanessa Duarte da
Miguel, Juliana Custódio
Marques, Julia Trece
Nascimento, Giselle Prado
Silva, Elisangela Ferreira da
Lewis‐Ximenez, Lia Laura
Villar, Livia Melo
Paula, Vanessa Salete de
dc.subject.other.pt_BR.fl_str_mv COVID-19
Citocinas
Hepatite
IL‐6
IL‐17
TNF‐α
topic COVID-19
Citocinas
Hepatite
IL‐6
IL‐17
TNF‐α
COVID-19
Cytokines
Hepatitis
IL‐6
IL‐17
TNF‐α
dc.subject.en.pt_BR.fl_str_mv COVID-19
Cytokines
Hepatitis
IL‐6
IL‐17
TNF‐α
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-28T17:29:17Z
dc.date.available.fl_str_mv 2022-06-28T17:29:17Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LEÓN, Fabiola Justina Fumero et al. Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus. Journal of Medical Virology, v. 94, p. 2296-2301, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53559
dc.identifier.issn.pt_BR.fl_str_mv 1096-9071
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.27614
identifier_str_mv LEÓN, Fabiola Justina Fumero et al. Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus. Journal of Medical Virology, v. 94, p. 2296-2301, 2022.
1096-9071
10.1002/jmv.27614
url https://www.arca.fiocruz.br/handle/icict/53559
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53559/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53559/2/FabiolaLeon_LiviaMVilar_etal_IOC_2022.pdf
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