Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23666 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. |
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Souza, Marina de AssisCastro, Maria C. A. Brelaz deOliveira, Andresa Pereira deAlmeida, Amanda Ferreira deAlmeida, Thays Miranda deReis, Luiza C.Medeiros, Ângela Cristina RapelaBrito, Maria Edileuza Felinto dePereira, Valéria Rêgo Alves2017-12-15T12:19:28Z2017-12-15T12:19:28Z2013SOUZA, M. de Assis et al. Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals. Microbial Pathogenesis, v. 57, p. 27–32, abr. 2013.1096-1208https://www.arca.fiocruz.br/handle/icict/2366610.1016/j.micpath.2013.02.004engElsevierCitocinasImunidade celularLeishmania braziliensisLeishmanioseÓxido nítricoCytokinesCellular immunityLeishmania braziliensisLeishmaniasisNitric oxideCitocinasbiossínteseLeishmania braziliensisimunologiaLeishmaniose CutâneaimunologiaLeishmaniose CutâneametabolismoÓxido NítricobiossínteseAdultoIdosoHumanosIdoso de 80 Anos ou maisAntígenos de ProtozoáriosimunologiaCitocinasimunologiaFemininoMasculinoLeucócitos MononuclearesimunologiaLeucócitos MononuclearesmetabolismoMeia-IdadeAdulto JovemCytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Universidade de São Paulo (IMT/USP). Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brazil.Universidade de Pernambuco (HUOC/UPE). Hospital Universitário Oswaldo Cruz. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Studies suggest the influence of immune response on the successful treatment of American tegumentary leishmaniasis (ATL), and indicate the existence of protective immunity in self-healed patients. Thus, the aim of this work was to quantify interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin (IL-) 10, IL-17, IL-22 and nitric oxide (NO) in culture supernatants of PBMC from patients with active disease (AD), after treatment (AT), and from self-healed (SH) and healthy subjects (CT), in response to Leishmania (Viannia) braziliensis insoluble antigen (AgIns). All groups of patients produced IFN-γ, indicating a predominant proinflammatory profile. AD and AT patients presented TNF-α levels, with a slight increase after therapy, whereas it was weakly quantified in SH. Interestingly, NO secretion was significant in these individuals, whereas IL-17 appeared in low levels and seems to be regulated by NO. Although IL-22 was detected in AD, its role is still questionable. The presence of IL-10 in all groups of patients suggests that the cytokine plays distinct roles in the disease. These results indicate that specific cellular immunity takes part against Leishmania, but with some similarities between the different clinical states herein described; these mediators seem to be necessary for the cure to occur.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23666/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALART. Cytokines and NO - SOUZA.pdfART. Cytokines and NO - SOUZA.pdfapplication/pdf327507https://www.arca.fiocruz.br/bitstream/icict/23666/2/ART.%20Cytokines%20and%20NO%20-%20SOUZA.pdf9cb92ad0b2d17463cf0552be0e260631MD52TEXTART. Cytokines and NO - SOUZA.pdf.txtART. 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| dc.title.pt_BR.fl_str_mv |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| title |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| spellingShingle |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals Souza, Marina de Assis Citocinas Imunidade celular Leishmania braziliensis Leishmaniose Óxido nítrico Cytokines Cellular immunity Leishmania braziliensis Leishmaniasis Nitric oxide Citocinas biossíntese Leishmania braziliensis imunologia Leishmaniose Cutânea imunologia Leishmaniose Cutânea metabolismo Óxido Nítrico biossíntese Adulto Idoso Humanos Idoso de 80 Anos ou mais Antígenos de Protozoários imunologia Citocinas imunologia Feminino Masculino Leucócitos Mononucleares imunologia Leucócitos Mononucleares metabolismo Meia-Idade Adulto Jovem |
| title_short |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| title_full |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| title_fullStr |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| title_full_unstemmed |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| title_sort |
Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals |
| author |
Souza, Marina de Assis |
| author_facet |
Souza, Marina de Assis Castro, Maria C. A. Brelaz de Oliveira, Andresa Pereira de Almeida, Amanda Ferreira de Almeida, Thays Miranda de Reis, Luiza C. Medeiros, Ângela Cristina Rapela Brito, Maria Edileuza Felinto de Pereira, Valéria Rêgo Alves |
| author_role |
author |
| author2 |
Castro, Maria C. A. Brelaz de Oliveira, Andresa Pereira de Almeida, Amanda Ferreira de Almeida, Thays Miranda de Reis, Luiza C. Medeiros, Ângela Cristina Rapela Brito, Maria Edileuza Felinto de Pereira, Valéria Rêgo Alves |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Marina de Assis Castro, Maria C. A. Brelaz de Oliveira, Andresa Pereira de Almeida, Amanda Ferreira de Almeida, Thays Miranda de Reis, Luiza C. Medeiros, Ângela Cristina Rapela Brito, Maria Edileuza Felinto de Pereira, Valéria Rêgo Alves |
| dc.subject.other.pt_BR.fl_str_mv |
Citocinas Imunidade celular Leishmania braziliensis Leishmaniose Óxido nítrico |
| topic |
Citocinas Imunidade celular Leishmania braziliensis Leishmaniose Óxido nítrico Cytokines Cellular immunity Leishmania braziliensis Leishmaniasis Nitric oxide Citocinas biossíntese Leishmania braziliensis imunologia Leishmaniose Cutânea imunologia Leishmaniose Cutânea metabolismo Óxido Nítrico biossíntese Adulto Idoso Humanos Idoso de 80 Anos ou mais Antígenos de Protozoários imunologia Citocinas imunologia Feminino Masculino Leucócitos Mononucleares imunologia Leucócitos Mononucleares metabolismo Meia-Idade Adulto Jovem |
| dc.subject.en.pt_BR.fl_str_mv |
Cytokines Cellular immunity Leishmania braziliensis Leishmaniasis Nitric oxide |
| dc.subject.decs.pt_BR.fl_str_mv |
Citocinas biossíntese Leishmania braziliensis imunologia Leishmaniose Cutânea imunologia Leishmaniose Cutânea metabolismo Óxido Nítrico biossíntese Adulto Idoso Humanos Idoso de 80 Anos ou mais Antígenos de Protozoários imunologia Citocinas imunologia Feminino Masculino Leucócitos Mononucleares imunologia Leucócitos Mononucleares metabolismo Meia-Idade Adulto Jovem |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. |
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2013 |
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2013 |
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2017-12-15T12:19:28Z |
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2017-12-15T12:19:28Z |
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info:eu-repo/semantics/article |
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SOUZA, M. de Assis et al. Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals. Microbial Pathogenesis, v. 57, p. 27–32, abr. 2013. |
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https://www.arca.fiocruz.br/handle/icict/23666 |
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1096-1208 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.micpath.2013.02.004 |
| identifier_str_mv |
SOUZA, M. de Assis et al. Cytokines and NO in American tegumentary leishmaniasis patients: profiles in active disease, after therapy and in self-healed individuals. Microbial Pathogenesis, v. 57, p. 27–32, abr. 2013. 1096-1208 10.1016/j.micpath.2013.02.004 |
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Elsevier |
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Elsevier |
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