Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.

Detalhes bibliográficos
Autor(a) principal: Araújo, Alan Moreira de
Data de Publicação: 2014
Outros Autores: Reis, Eliana Almeida Gomes, Athanazio, Daniel Abensur, Ribeiro, Guilherme de Sousa, Hagan, José Edward, Araujo, Guilherme C, Damião, Alcinéia Oliveira, Couto, Nicolli S, Ko, Albert Icksang, Dutra, Alberto Noronha, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10489
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
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spelling Araújo, Alan Moreira deReis, Eliana Almeida GomesAthanazio, Daniel AbensurRibeiro, Guilherme de SousaHagan, José EdwardAraujo, Guilherme CDamião, Alcinéia OliveiraCouto, Nicolli SKo, Albert IcksangDutra, Alberto NoronhaReis, Mitermayer Galvão dos2015-05-25T13:54:00Z2015-05-25T13:54:00Z2014ARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014.1476-1645https://www.arca.fiocruz.br/handle/icict/1048910.4269/ajtmh.13-0667engAmerican Society of Tropical Medicine and HygieneOxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFederal University of Bahia. Institute of Collective Health. Salvador, BA, BrasilYale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilYale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilLeptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stressLesão Renal Aguda/sangueGlutationa/sangueLeptospirose/sangueEstresse OxidativoEspécies de Oxigênio Reativas/sangueTrombocitopenia/sangueAdolescenteAdultoMarcadores Biológicos/sangueEstudos de Casos e ControlesEstudos de CoortesCreatinina/sangueFemininoHumanosMasculinoMeia-IdadePotássio/sangueÍndice de Gravidade de DoençaAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10489/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALAraujo AM Oxidative....pdfAraujo AM Oxidative....pdfapplication/pdf667444https://www.arca.fiocruz.br/bitstream/icict/10489/2/Araujo%20AM%20Oxidative....pdf941fcf775da07a43ac3cfbcb9695cfdcMD52TEXTAraujo AM Oxidative....pdf.txtAraujo AM Oxidative....pdf.txtExtracted texttext/plain27351https://www.arca.fiocruz.br/bitstream/icict/10489/3/Araujo%20AM%20Oxidative....pdf.txt193b814b7d14aad410ff2427be879b0aMD53icict/104892023-03-15 14:33:17.491oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
title Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
spellingShingle Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
Araújo, Alan Moreira de
Lesão Renal Aguda/sangue
Glutationa/sangue
Leptospirose/sangue
Estresse Oxidativo
Espécies de Oxigênio Reativas/sangue
Trombocitopenia/sangue
Adolescente
Adulto
Marcadores Biológicos/sangue
Estudos de Casos e Controles
Estudos de Coortes
Creatinina/sangue
Feminino
Humanos
Masculino
Meia-Idade
Potássio/sangue
Índice de Gravidade de Doença
Adulto Jovem
title_short Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
title_full Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
title_fullStr Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
title_full_unstemmed Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
title_sort Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
author Araújo, Alan Moreira de
author_facet Araújo, Alan Moreira de
Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Ribeiro, Guilherme de Sousa
Hagan, José Edward
Araujo, Guilherme C
Damião, Alcinéia Oliveira
Couto, Nicolli S
Ko, Albert Icksang
Dutra, Alberto Noronha
Reis, Mitermayer Galvão dos
author_role author
author2 Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Ribeiro, Guilherme de Sousa
Hagan, José Edward
Araujo, Guilherme C
Damião, Alcinéia Oliveira
Couto, Nicolli S
Ko, Albert Icksang
Dutra, Alberto Noronha
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Alan Moreira de
Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Ribeiro, Guilherme de Sousa
Hagan, José Edward
Araujo, Guilherme C
Damião, Alcinéia Oliveira
Couto, Nicolli S
Ko, Albert Icksang
Dutra, Alberto Noronha
Reis, Mitermayer Galvão dos
dc.subject.decs.pt_BR.fl_str_mv Lesão Renal Aguda/sangue
Glutationa/sangue
Leptospirose/sangue
Estresse Oxidativo
Espécies de Oxigênio Reativas/sangue
Trombocitopenia/sangue
Adolescente
Adulto
Marcadores Biológicos/sangue
Estudos de Casos e Controles
Estudos de Coortes
Creatinina/sangue
Feminino
Humanos
Masculino
Meia-Idade
Potássio/sangue
Índice de Gravidade de Doença
Adulto Jovem
topic Lesão Renal Aguda/sangue
Glutationa/sangue
Leptospirose/sangue
Estresse Oxidativo
Espécies de Oxigênio Reativas/sangue
Trombocitopenia/sangue
Adolescente
Adulto
Marcadores Biológicos/sangue
Estudos de Casos e Controles
Estudos de Coortes
Creatinina/sangue
Feminino
Humanos
Masculino
Meia-Idade
Potássio/sangue
Índice de Gravidade de Doença
Adulto Jovem
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-25T13:54:00Z
dc.date.available.fl_str_mv 2015-05-25T13:54:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10489
dc.identifier.issn.none.fl_str_mv 1476-1645
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.13-0667
identifier_str_mv ARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014.
1476-1645
10.4269/ajtmh.13-0667
url https://www.arca.fiocruz.br/handle/icict/10489
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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