Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.

Quintans, Jullyana de Souza Siqueira; Barreto, Rosana Siqueira de Souza; Lucca Júnior, Waldecy de; Villarreal, Cristiane Flora; Kaneto, Carla Martins; Soares, Milena Botelho Pereira; Branco, Alexsandro; Almeida, Jackson Roberto Guedes da Silva; Taranto, Alex Gutterres; Antoniolli, Angelo Roberto; Freitas, Rivelilson Mendes de; Quintans Junior, Lucindo José

Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.

Detalhes bibliográficos
Autor(a) principal:	Quintans, Jullyana de Souza Siqueira
Data de Publicação:	2014
Outros Autores:	Barreto, Rosana Siqueira de Souza, Lucca Júnior, Waldecy de, Villarreal, Cristiane Flora, Kaneto, Carla Martins, Soares, Milena Botelho Pereira, Branco, Alexsandro, Almeida, Jackson Roberto Guedes da Silva, Taranto, Alex Gutterres, Antoniolli, Angelo Roberto, Freitas, Rivelilson Mendes de, Quintans Junior, Lucindo José
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/8461
Resumo:	Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil

Metadados do item

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repository_id_str	2135
spelling	Quintans, Jullyana de Souza SiqueiraBarreto, Rosana Siqueira de SouzaLucca Júnior, Waldecy deVillarreal, Cristiane FloraKaneto, Carla MartinsSoares, Milena Botelho PereiraBranco, AlexsandroAlmeida, Jackson Roberto Guedes da SilvaTaranto, Alex GutterresAntoniolli, Angelo RobertoFreitas, Rivelilson Mendes deQuintans Junior, Lucindo José2014-09-26T18:58:13Z2014-09-26T18:58:13Z2014QUINTANS, J. S. S. et al. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules, v. 19, n. 6, p. 8303-8316, 2014.1420-3049https://www.arca.fiocruz.br/handle/icict/846110.3390/molecules19068303engMDPIEvidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, BrasilUniversidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, BrasilUniversidade Estadual de Feira de Santana. Colegiado de Ciências Farmacêuticas. Feira de Santana, BA, BrasilUniversidade Federal do Vale do São Francisco. Colegiado de Ciências Farmacêuticas. Petrolina, PE, BrasilUniversidade Federal de São João Del-Rei. Curso de Farmácia. Divinópolis, MG, BrasilUniversidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, BrasilUniversidade Federal do Piauí. Departamento de Farmácia. Teresina, PI, BrasilUniversidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, BrasilHecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as 'sisal', and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflammatory models, as well as its possible involvement with c-fos expression on spinal cord area and cytokines to produces analgesic profile. Acute pretreatment with HA (5, 10, or 20 mg/kg; i.p.) inhibited the development of mechanical hyperalgesia induced by carrageenan, TNF-Î±, dopamine and PGE2. Additionally, the immunofluorescence data demonstrated that acute pretreatment with HA, at all doses tested, significantly inhibited Fos-like expression in the spinal cord dorsal horn normally observed after carrageenan-inflammation. Moreover, HA did not affect the motor performance of the mice as tested in the Rota rod test. This antinociceptive profile seems to be related, at least in part, to a reduction of pro-inflammatory cytokines, as IL-1ß. The present results suggest that HA attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms.Hecogenin acetateSteroidal sapogeninSpinal cordC-fosIL-1βPaininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8461/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALQuintans J Evidence for the....pdfQuintans J Evidence for the....pdfapplication/pdf528767https://www.arca.fiocruz.br/bitstream/icict/8461/2/Quintans%20J%20Evidence%20for%20the....pdf630e2db1a3b691b62ccc9a06f8e892e7MD52TEXTQuintans J Evidence for the....pdf.txtQuintans J Evidence for the....pdf.txtExtracted texttext/plain41251https://www.arca.fiocruz.br/bitstream/icict/8461/3/Quintans%20J%20Evidence%20for%20the....pdf.txteb7bddc909c0b9d41f678a8178bb5629MD53icict/84612023-03-15 14:33:56.282oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
title	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
spellingShingle	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Quintans, Jullyana de Souza Siqueira Hecogenin acetate Steroidal sapogenin Spinal cord C-fos IL-1β Pain
title_short	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
title_full	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
title_fullStr	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
title_full_unstemmed	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
title_sort	Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
author	Quintans, Jullyana de Souza Siqueira
author_facet	Quintans, Jullyana de Souza Siqueira Barreto, Rosana Siqueira de Souza Lucca Júnior, Waldecy de Villarreal, Cristiane Flora Kaneto, Carla Martins Soares, Milena Botelho Pereira Branco, Alexsandro Almeida, Jackson Roberto Guedes da Silva Taranto, Alex Gutterres Antoniolli, Angelo Roberto Freitas, Rivelilson Mendes de Quintans Junior, Lucindo José
author_role	author
author2	Barreto, Rosana Siqueira de Souza Lucca Júnior, Waldecy de Villarreal, Cristiane Flora Kaneto, Carla Martins Soares, Milena Botelho Pereira Branco, Alexsandro Almeida, Jackson Roberto Guedes da Silva Taranto, Alex Gutterres Antoniolli, Angelo Roberto Freitas, Rivelilson Mendes de Quintans Junior, Lucindo José
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Quintans, Jullyana de Souza Siqueira Barreto, Rosana Siqueira de Souza Lucca Júnior, Waldecy de Villarreal, Cristiane Flora Kaneto, Carla Martins Soares, Milena Botelho Pereira Branco, Alexsandro Almeida, Jackson Roberto Guedes da Silva Taranto, Alex Gutterres Antoniolli, Angelo Roberto Freitas, Rivelilson Mendes de Quintans Junior, Lucindo José
dc.subject.en.pt_BR.fl_str_mv	Hecogenin acetate Steroidal sapogenin Spinal cord C-fos IL-1β Pain
topic	Hecogenin acetate Steroidal sapogenin Spinal cord C-fos IL-1β Pain
description	Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil
publishDate	2014
dc.date.accessioned.fl_str_mv	2014-09-26T18:58:13Z
dc.date.available.fl_str_mv	2014-09-26T18:58:13Z
dc.date.issued.fl_str_mv	2014
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	QUINTANS, J. S. S. et al. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules, v. 19, n. 6, p. 8303-8316, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/8461
dc.identifier.issn.none.fl_str_mv	1420-3049
dc.identifier.doi.none.fl_str_mv	10.3390/molecules19068303
identifier_str_mv	QUINTANS, J. S. S. et al. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules, v. 19, n. 6, p. 8303-8316, 2014. 1420-3049 10.3390/molecules19068303
url	https://www.arca.fiocruz.br/handle/icict/8461
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/8461/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/8461/2/Quintans%20J%20Evidence%20for%20the....pdf https://www.arca.fiocruz.br/bitstream/icict/8461/3/Quintans%20J%20Evidence%20for%20the....pdf.txt
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Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.

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