Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism

Detalhes bibliográficos
Autor(a) principal: Cuesta-Astroz, Yesid
Data de Publicação: 2019
Outros Autores: Santos, Alberto, Oliveira, Guilherme Corrêa de, Jensen, Lars J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36524
Resumo: 2021-01-01
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spelling Cuesta-Astroz, YesidSantos, AlbertoOliveira, Guilherme Corrêa deJensen, Lars J.2019-10-17T14:04:47Z2019-10-17T14:04:47Z2019CUESTA-ASTROZ, Yesid et al. Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism. Frontiers in Immunology, v. 10, p. 1-17, 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3652410.3389/fimmu.2019.00212engFrontiers Research FoundationAnalysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Novo Nordisk Foundation Center for Protein Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark.Instituto Tecnológico Vale. Desenvolvimento Genômico. Belém, PA, Brasil.Novo Nordisk Foundation Center for Protein Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark.The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental identification of host-parasite molecular interactions remains challenging, and the use of computational predictions becomes then necessary. Here, we propose a computational integrative approach to predict host-parasite protein-protein interaction (PPI) networks resulting from the human infection by 15 different eukaryotic parasites. We used an orthology-based approach to transfer high-confidence intraspecies interactions obtained from the STRING database to the corresponding interspecies homolog protein pairs in the host-parasite system. Our approach uses either the parasites predicted secretome and membrane proteins, or only the secretome, depending on whether they are uni- or multi-cellular, respectively, to reduce the number of false predictions. Moreover, the host proteome is filtered for proteins expressed in selected cellular localizations and tissues supporting the parasite growth. We evaluated the inferred interactions by analyzing the enriched biological processes and pathways in the predicted networks and their association with known parasitic invasion and evasion mechanisms. The resulting PPI networks were compared across parasites to identify common mechanisms that may define a global pathogenic hallmark. We also provided a study case focusing on a closer examination of the human-S. mansoni predicted interactome, detecting central proteins that have relevant roles in the human-S. mansoni network, and identifying tissue-specific interactions with key roles in the life cycle of the parasite.Biological networksComputational biologyHost–parasite interactionsParasitologySchistosomiasisSystems biologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/36524/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAnalysis of Predicted Host–Parasite Interactomes.pdfAnalysis of Predicted Host–Parasite Interactomes.pdfapplication/pdf1430961https://www.arca.fiocruz.br/bitstream/icict/36524/2/Analysis%20of%20Predicted%20Host%e2%80%93Parasite%20Interactomes.pdf8cf36831373b15c9d21f8f34d419bf26MD52TEXTAnalysis 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dc.title.pt_BR.fl_str_mv Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
title Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
spellingShingle Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
Cuesta-Astroz, Yesid
Biological networks
Computational biology
Host–parasite interactions
Parasitology
Schistosomiasis
Systems biology
title_short Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
title_full Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
title_fullStr Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
title_full_unstemmed Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
title_sort Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism
author Cuesta-Astroz, Yesid
author_facet Cuesta-Astroz, Yesid
Santos, Alberto
Oliveira, Guilherme Corrêa de
Jensen, Lars J.
author_role author
author2 Santos, Alberto
Oliveira, Guilherme Corrêa de
Jensen, Lars J.
author2_role author
author
author
dc.contributor.author.fl_str_mv Cuesta-Astroz, Yesid
Santos, Alberto
Oliveira, Guilherme Corrêa de
Jensen, Lars J.
dc.subject.en.pt_BR.fl_str_mv Biological networks
Computational biology
Host–parasite interactions
Parasitology
Schistosomiasis
Systems biology
topic Biological networks
Computational biology
Host–parasite interactions
Parasitology
Schistosomiasis
Systems biology
description 2021-01-01
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-17T14:04:47Z
dc.date.available.fl_str_mv 2019-10-17T14:04:47Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUESTA-ASTROZ, Yesid et al. Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism. Frontiers in Immunology, v. 10, p. 1-17, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36524
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2019.00212
identifier_str_mv CUESTA-ASTROZ, Yesid et al. Analysis of Predicted Host-Parasite Interactomes Reveals Commonalities and Specificities Related to Parasitic Lifestyle and Tissues Tropism. Frontiers in Immunology, v. 10, p. 1-17, 2019.
1664-3224
10.3389/fimmu.2019.00212
url https://www.arca.fiocruz.br/handle/icict/36524
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36524/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36524/2/Analysis%20of%20Predicted%20Host%e2%80%93Parasite%20Interactomes.pdf
https://www.arca.fiocruz.br/bitstream/icict/36524/3/Analysis%20of%20Predicted%20Host%e2%80%93Parasite%20Interactomes.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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