Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction

Detalhes bibliográficos
Autor(a) principal: Santos, Isis Fernandes Magalhães
Data de Publicação: 2004
Outros Autores: Souza, Márcia Maria de, Lima, Carolina Silva Costa, Andrade, Sonia Gumes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/3265
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Santos, Isis Fernandes MagalhãesSouza, Márcia Maria deLima, Carolina Silva CostaAndrade, Sonia Gumes2011-10-20T19:57:53Z2011-10-20T19:57:53Z2004SANTOS, Isis Fernandes Magalhães et al. Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 407-413, jun. 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/326510.1590/S0074-02762004000400011engInfection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis inductioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.The influence of different Trypanosoma cruzi biodemes on the evolution of the infection and on the histopathological lesions of the heart and skeletal muscles, during the experimental infection of Calomys callosus, was investigated. Three groups of C. callosus were infected, respectively, with parasite strains representative of three different Biodemes: Type I (Y strain), Type II (21 SF strain), and Type III (Colombian strain). For each group, normal C. callosus were also used as controls. Marked differences have been detected in the responses of C. callosus to the infection with the three strains in this model. The strains Types I and II (Y and 21 SF) determined moderate lesions, mostly in the myocardium, with low parasitism, a rapid course, and total regression of the lesions by the 60th day of infection. Differently, Type III strain (Colombian), was more pathogenic for C. callosus and induced necrotic-inflammatory lesions in skeletal muscles and myocardium, in correspondence to intracellular parasitism. Proliferation of fibroblasts and amorphous matrix deposits, followed by interstitial fibrosis were present. Progressive regression of the inflammatory changes and collagen deposits occurred spontaneously. The progression and regression of both inflammation and fibrosis induced by the Colombian strain were further submitted to quantitative evaluation by morphometry. Results of the morphometric studies presented good correlation with the histopathological findings. The results confirm the importance of the different biodemes in the determination of tissue lesions and the peculiarities of response of C. callosus to infection with T. cruzi.Calomys callosusTrypanosoma cruziBiodemesHistopathologyMorphometry fibrosisInflammationFatores de TempoTrypanosoma CruziAnimaisMasculinoDoença de ChagasFibroseMúsculo EsqueléticoMiocárdioParasitemiaRoedoresinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMagalhaes-Santos IF Infection od Calomys callosus....pdfMagalhaes-Santos IF Infection od Calomys callosus....pdfapplication/pdf163145https://www.arca.fiocruz.br/bitstream/icict/3265/1/Magalhaes-Santos%20IF%20Infection%20od%20Calomys%20callosus....pdfbdf49b18cc4f41bf3e3fa241d40fdf91MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3265/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTMagalhaes-Santos IF Infection od Calomys callosus....pdf.txtMagalhaes-Santos IF Infection od Calomys callosus....pdf.txtExtracted texttext/plain27849https://www.arca.fiocruz.br/bitstream/icict/3265/5/Magalhaes-Santos%20IF%20Infection%20od%20Calomys%20callosus....pdf.txt8ed33cc7e6c23c0028a7eab680d48f91MD55THUMBNAILMagalhaes-Santos IF Infection od Calomys callosus....pdf.jpgMagalhaes-Santos IF Infection od Calomys callosus....pdf.jpgGenerated Thumbnailimage/jpeg2476https://www.arca.fiocruz.br/bitstream/icict/3265/4/Magalhaes-Santos%20IF%20Infection%20od%20Calomys%20callosus....pdf.jpg056248cf99ae976a5205165befbeb236MD54icict/32652023-03-15 14:33:24.586oai:www.arca.fiocruz.br:icict/3265Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
title Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
spellingShingle Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
Santos, Isis Fernandes Magalhães
Calomys callosus
Trypanosoma cruzi
Biodemes
Histopathology
Morphometry fibrosis
Inflammation
Fatores de Tempo
Trypanosoma Cruzi
Animais
Masculino
Doença de Chagas
Fibrose
Músculo Esquelético
Miocárdio
Parasitemia
Roedores
title_short Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
title_full Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
title_fullStr Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
title_full_unstemmed Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
title_sort Infection of Calomys callosus (Rodentia Cricetidae) with Strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction
author Santos, Isis Fernandes Magalhães
author_facet Santos, Isis Fernandes Magalhães
Souza, Márcia Maria de
Lima, Carolina Silva Costa
Andrade, Sonia Gumes
author_role author
author2 Souza, Márcia Maria de
Lima, Carolina Silva Costa
Andrade, Sonia Gumes
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, Isis Fernandes Magalhães
Souza, Márcia Maria de
Lima, Carolina Silva Costa
Andrade, Sonia Gumes
dc.subject.en.pt_BR.fl_str_mv Calomys callosus
Trypanosoma cruzi
Biodemes
Histopathology
Morphometry fibrosis
Inflammation
Fatores de Tempo
Trypanosoma Cruzi
Animais
Masculino
topic Calomys callosus
Trypanosoma cruzi
Biodemes
Histopathology
Morphometry fibrosis
Inflammation
Fatores de Tempo
Trypanosoma Cruzi
Animais
Masculino
Doença de Chagas
Fibrose
Músculo Esquelético
Miocárdio
Parasitemia
Roedores
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas
Fibrose
Músculo Esquelético
Miocárdio
Parasitemia
Roedores
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-10-20T19:57:53Z
dc.date.available.fl_str_mv 2011-10-20T19:57:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Isis Fernandes Magalhães et al. Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 407-413, jun. 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/3265
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762004000400011
identifier_str_mv SANTOS, Isis Fernandes Magalhães et al. Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 407-413, jun. 2004.
0074-0276
10.1590/S0074-02762004000400011
url https://www.arca.fiocruz.br/handle/icict/3265
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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