Antiprotozoal action of synthetic cinnamic acid analogs

Detalhes bibliográficos
Autor(a) principal: Santos, Ana Paula de Azevedo dos
Data de Publicação: 2018
Outros Autores: Fialho, Saara Nery, Medeiros, Daniel Sol Sol de, Garay, Ana Fidelina Gómez, Diaz, Jorge Alfonso Ruiz, Vega Gómez, Maria Celeste, Teles, Carolina Bioni Garcia, Calderon, Leonardo de Azevedo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35577
Resumo: Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil.
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spelling Santos, Ana Paula de Azevedo dosFialho, Saara NeryMedeiros, Daniel Sol Sol deGaray, Ana Fidelina GómezDiaz, Jorge Alfonso RuizVega Gómez, Maria CelesteTeles, Carolina Bioni GarciaCalderon, Leonardo de Azevedo2019-09-13T15:27:30Z2019-09-13T15:27:30Z2018SANTOS, Ana Paula de Azevedo dos et all. Antiprotozoal action of synthetic cinnamic acid analogs. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 849-853, 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3557710.1590/0037-8682-0499-20171678-9849engRevista da Sociedade Brasileira de Medicina TropicalAntiprotozoal action of synthetic cinnamic acid analogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Centro Universitário São Lucas. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil.Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil. / Centro para el Desarrollo de Investigación Científica. Asunción, Paraguay.Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil. / Centro para el Desarrollo de Investigación Científica. Asunción, Paraguay.Centro para el Desarrollo de Investigación Científica. Asunción, Paraguay.Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Centro Universitário São Lucas. Porto Velho, RO, Brasil. / Instituto Nacional de Epidemiologia na Amazônia Ocidental. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil.Introduction: Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. Methods: In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. Results: Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. Conclusions: Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.BioactivityCinnamic acidLeishmaniasisSyntheticinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35577/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAntiprotozoal action of synthetic cinnamic acid analogs.pdfAntiprotozoal action of synthetic cinnamic acid analogs.pdfapplication/pdf1282999https://www.arca.fiocruz.br/bitstream/icict/35577/2/Antiprotozoal%20action%20of%20synthetic%20cinnamic%20acid%20analogs.pdf9055bccde66932ebd2ae36450ab4d6f5MD52TEXTAntiprotozoal action of synthetic cinnamic acid analogs.pdf.txtAntiprotozoal action of synthetic cinnamic acid analogs.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Antiprotozoal action of synthetic cinnamic acid analogs
title Antiprotozoal action of synthetic cinnamic acid analogs
spellingShingle Antiprotozoal action of synthetic cinnamic acid analogs
Santos, Ana Paula de Azevedo dos
Bioactivity
Cinnamic acid
Leishmaniasis
Synthetic
title_short Antiprotozoal action of synthetic cinnamic acid analogs
title_full Antiprotozoal action of synthetic cinnamic acid analogs
title_fullStr Antiprotozoal action of synthetic cinnamic acid analogs
title_full_unstemmed Antiprotozoal action of synthetic cinnamic acid analogs
title_sort Antiprotozoal action of synthetic cinnamic acid analogs
author Santos, Ana Paula de Azevedo dos
author_facet Santos, Ana Paula de Azevedo dos
Fialho, Saara Nery
Medeiros, Daniel Sol Sol de
Garay, Ana Fidelina Gómez
Diaz, Jorge Alfonso Ruiz
Vega Gómez, Maria Celeste
Teles, Carolina Bioni Garcia
Calderon, Leonardo de Azevedo
author_role author
author2 Fialho, Saara Nery
Medeiros, Daniel Sol Sol de
Garay, Ana Fidelina Gómez
Diaz, Jorge Alfonso Ruiz
Vega Gómez, Maria Celeste
Teles, Carolina Bioni Garcia
Calderon, Leonardo de Azevedo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Ana Paula de Azevedo dos
Fialho, Saara Nery
Medeiros, Daniel Sol Sol de
Garay, Ana Fidelina Gómez
Diaz, Jorge Alfonso Ruiz
Vega Gómez, Maria Celeste
Teles, Carolina Bioni Garcia
Calderon, Leonardo de Azevedo
dc.subject.en.en.fl_str_mv Bioactivity
Cinnamic acid
Leishmaniasis
Synthetic
topic Bioactivity
Cinnamic acid
Leishmaniasis
Synthetic
description Fundação Oswaldo Cruz. Fiocruz Rondônia. Plataforma de Bioensaios em Malária e Leishmaniose. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Programa de Pós-graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Universidade Federal de Rondônia. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-09-13T15:27:30Z
dc.date.available.fl_str_mv 2019-09-13T15:27:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Ana Paula de Azevedo dos et all. Antiprotozoal action of synthetic cinnamic acid analogs. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 849-853, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35577
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/0037-8682-0499-2017
dc.identifier.eissn.pt_BR.fl_str_mv 1678-9849
identifier_str_mv SANTOS, Ana Paula de Azevedo dos et all. Antiprotozoal action of synthetic cinnamic acid analogs. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 849-853, 2018.
0037-8682
10.1590/0037-8682-0499-2017
1678-9849
url https://www.arca.fiocruz.br/handle/icict/35577
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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