Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Albasanz-Puig, Adaia; Durà-Miralles, Xavier; Laporte-Amargós, Julia; Mussetti, Alberto; Ruiz-Camps, Isabel; Puerta-Alcalde, Pedro; Abdala, Edson; Oltolini, Chiara; Akova, Murat; Montejo, José Miguel; Mikulska, Malgorzata; Martín-Dávila, Pilar; Herrera, Fabián; Gasch, Oriol; Drgona, Lubos; Morales, Hugo Manuel Paz; Brunel, Anne-Sophie; García, Estefanía; Isler, Burcu; Kern, Winfried V.; Retamar-Gentil, Pilar; Aguado, José María; Montero, Milagros; Kanj, Souha S.; Sipahi, Oguz R.; Calik, Sebnem; Márquez-Gómez, Ignacio; Marin, Jorge I.; Gomes, Marisa Z. R.; Hemmati, Philipp; Araos, Rafael; Peghin, Maddalena; del Pozo, José Luis; Yáñez, Lucrecia; Tilley, Robert; Manzur, Adriana; Novo, Andres; Pallarès, Natàlia; Bergas, Alba; Carratalà, Jordi; Gudiol, Carlota; on behalf of the IRONIC Study Group

Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Detalhes bibliográficos
Autor(a) principal:	Albasanz-Puig, Adaia
Data de Publicação:	2022
Outros Autores:	Durà-Miralles, Xavier, Laporte-Amargós, Julia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Abdala, Edson, Oltolini, Chiara, Akova, Murat, Montejo, José Miguel, Mikulska, Malgorzata, Martín-Dávila, Pilar, Herrera, Fabián, Gasch, Oriol, Drgona, Lubos, Morales, Hugo Manuel Paz, Brunel, Anne-Sophie, García, Estefanía, Isler, Burcu, Kern, Winfried V., Retamar-Gentil, Pilar, Aguado, José María, Montero, Milagros, Kanj, Souha S., Sipahi, Oguz R., Calik, Sebnem, Márquez-Gómez, Ignacio, Marin, Jorge I., Gomes, Marisa Z. R., Hemmati, Philipp, Araos, Rafael, Peghin, Maddalena, del Pozo, José Luis, Yáñez, Lucrecia, Tilley, Robert, Manzur, Adriana, Novo, Andres, Pallarès, Natàlia, Bergas, Alba, Carratalà, Jordi, Gudiol, Carlota, on behalf of the IRONIC Study Group
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/54622
Resumo:	Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain / Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain.

Metadados do item

id	CRUZ_1ba9e721a0a0d0574e70b8c3df73b708
oai_identifier_str	oai:www.arca.fiocruz.br:icict/54622
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Albasanz-Puig, AdaiaDurà-Miralles, XavierLaporte-Amargós, JuliaMussetti, AlbertoRuiz-Camps, IsabelPuerta-Alcalde, PedroAbdala, EdsonOltolini, ChiaraAkova, MuratMontejo, José MiguelMikulska, MalgorzataMartín-Dávila, PilarHerrera, FabiánGasch, OriolDrgona, LubosMorales, Hugo Manuel PazBrunel, Anne-SophieGarcía, EstefaníaIsler, BurcuKern, Winfried V.Retamar-Gentil, PilarAguado, José MaríaMontero, MilagrosKanj, Souha S.Sipahi, Oguz R.Calik, SebnemMárquez-Gómez, IgnacioMarin, Jorge I.Gomes, Marisa Z. R.Hemmati, PhilippAraos, RafaelPeghin, Maddalenadel Pozo, José LuisYáñez, LucreciaTilley, RobertManzur, AdrianaNovo, AndresPallarès, NatàliaBergas, AlbaCarratalà, JordiGudiol, Carlotaon behalf of the IRONIC Study Group2022-08-12T13:32:25Z2022-08-12T13:32:25Z2022ALBASANZ-PUIG, Adaia et al. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganims, v. 10, 733, p. 1 - 14, Mar. 2022.2076-2607https://www.arca.fiocruz.br/handle/icict/5462210.3390/ microorganisms10040733engMDPIPseudomonas aeruginosaInfecção da corrente sanguíneaPneumoniaChoque sépticoNeutropeniaPseudomonas aeruginosaBloodstream infectionPneumoniaSeptic shockNeutropeniaEffect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumoniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain / Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain.Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain.Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain.Hematology Department, Catalan Institute of Oncology (ICO)-Duran i Reynals Hospital, IDIBELL. Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain / Infectious Diseases Department, Vall d’Hebron University Hospital, 08035 Barcelona, Spain.Infectious Diseases Department, Hospital Clínic i Provincial, 08035 Barcelona, Spain.Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo. São Paulo, SP, Brasil.Unit of Infectious and Tropical Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.Department of Infectious Diseases, Hacettepe University School of Medicine, 06230 Ankara, Turkey.Infectious Diseases Department, Cruces University Hospital, 48903 Bilbao, Spain.Division of Infectious Diseases, Department of Health Sciences, University of Genoa (DISSAL) and Ospedale Policlinico San Martino, 16132 Genoa, Italy.Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain / Infectious Diseases Department, Ramon y Cajal Hospital, 28034 Madrid, Spain.Infectious Diseases Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires. Argentina.Infectious Diseases Department, Parc Taulí University Hospital, Sabadell, 08208 Barcelona, Spain.Oncohematology Department, Comenius University and National Cancer Institute. Bratislava, Slovakia.Hospital Erasto Gaertner. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil.Infectious Diseases Department, Department of Medicine, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland.Haematology Department, Reina Sofía University Hospital-IMIBIC-UCO, 14004 Córdoba, Spain.Department of Infectious Diseases and Clinical Microbiology, Istanbul Education and Research Hospital, Istanbul 34668, Turkey.Division of Infectious Diseases, Department of Medicine II, University of Freiburg Medical Center and Faculty of Medicine, 79110 Freiburg, Germany.Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain / Unit of Infectious Diseases and Microbiology, University Hospital Virgen Macarena, Department of Medicine, Universidad de Sevilla, Institute of Biomedicine of Seville, Virgen del Rocío and Virgen Macarena University Hospitals/CSIC/University of Seville, 41013 Seville, Spain.Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain / Infectious Diseases Unit, Instituto de Investigación Hospital “12 de Octubre” (i + 12), “12 de Octubre” University Hospital, School of Medicine, Universidad Complutense, 28041 Madrid, Spain.Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d’Investigations Mèdiques (IMIM), Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain.Infectious Diseases Division, American University of Beirut Medical Center, Beirut 110236, Lebanon.Faculty of Medicine, Ege University, Izmir 35040, Turkey.Department of Infectious Diseases and Clinical Microbiology, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir 35170, Turkey.Infectious Diseases Department, Hospital Regional de Málaga, 29010 Málaga, Spain.Infectious Diseases and Clinical Microbiology Department, Clínica Maraya, Pereira, Colombia, Critical Care and Clinical Microbiology Department, Manizales 170001-17, Colombia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Academic Teaching Hospital of Charité University Medical School, 10117 Berlin, Germany.Facultad de Medicina Clínica, Instituto de Ciencias e Innovación en Medicina, Alemana Universidad del Desarrollo, Santiago de Chile, and Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago de Chile 12461, Chile.Infectious Diseases Clinic, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy.Infectious Diseases and Microbiology Unit, Faculty of Medicine, Navarra University Clinic, 31008 Pamplona, Spain.Haematology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.Microbiology Department, University Hospitals Plymouth NHS Trust, Plymouth 8DH, UK;.Infectious Diseases, Hospital Rawson, San Juan J5400, Argentina.Haematology Department, Son Espases University Hospital, 07120 Palma de Mallorca, Spain.Statistics Advisory Service, Institute of Biomedical Research of Bellvitge, Rovira i Virgili University, 08908 Tarragona, Spain.Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain.Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain / Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain.Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain / Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain / Infectious Diseases Unit, Catalan Institute of Oncology (ICO), Duran i Reynals Hospital, IDIBELL, 08908 Barcelona, Spain.on behalf of the IRONIC Study GroupTo assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006–2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01–2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27–0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76–2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54622/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarisaZR_Gomes_etal_IOC_2022.pdfMarisaZR_Gomes_etal_IOC_2022.pdfapplication/pdf1083335https://www.arca.fiocruz.br/bitstream/icict/54622/2/MarisaZR_Gomes_etal_IOC_2022.pdf63c0992ad31e347fd0c0b1671adaf127MD52icict/546222022-08-12 10:32:25.075oai:www.arca.fiocruz.br:icict/54622Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-12T13:32:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
title	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
spellingShingle	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia Albasanz-Puig, Adaia Pseudomonas aeruginosa Infecção da corrente sanguínea Pneumonia Choque séptico Neutropenia Pseudomonas aeruginosa Bloodstream infection Pneumonia Septic shock Neutropenia
title_short	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
title_full	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
title_fullStr	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
title_full_unstemmed	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
title_sort	Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia
author	Albasanz-Puig, Adaia
author_facet	Albasanz-Puig, Adaia Durà-Miralles, Xavier Laporte-Amargós, Julia Mussetti, Alberto Ruiz-Camps, Isabel Puerta-Alcalde, Pedro Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, José Miguel Mikulska, Malgorzata Martín-Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Morales, Hugo Manuel Paz Brunel, Anne-Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Retamar-Gentil, Pilar Aguado, José María Montero, Milagros Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez-Gómez, Ignacio Marin, Jorge I. Gomes, Marisa Z. R. Hemmati, Philipp Araos, Rafael Peghin, Maddalena del Pozo, José Luis Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andres Pallarès, Natàlia Bergas, Alba Carratalà, Jordi Gudiol, Carlota on behalf of the IRONIC Study Group
author_role	author
author2	Durà-Miralles, Xavier Laporte-Amargós, Julia Mussetti, Alberto Ruiz-Camps, Isabel Puerta-Alcalde, Pedro Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, José Miguel Mikulska, Malgorzata Martín-Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Morales, Hugo Manuel Paz Brunel, Anne-Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Retamar-Gentil, Pilar Aguado, José María Montero, Milagros Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez-Gómez, Ignacio Marin, Jorge I. Gomes, Marisa Z. R. Hemmati, Philipp Araos, Rafael Peghin, Maddalena del Pozo, José Luis Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andres Pallarès, Natàlia Bergas, Alba Carratalà, Jordi Gudiol, Carlota on behalf of the IRONIC Study Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Albasanz-Puig, Adaia Durà-Miralles, Xavier Laporte-Amargós, Julia Mussetti, Alberto Ruiz-Camps, Isabel Puerta-Alcalde, Pedro Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, José Miguel Mikulska, Malgorzata Martín-Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Morales, Hugo Manuel Paz Brunel, Anne-Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Retamar-Gentil, Pilar Aguado, José María Montero, Milagros Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez-Gómez, Ignacio Marin, Jorge I. Gomes, Marisa Z. R. Hemmati, Philipp Araos, Rafael Peghin, Maddalena del Pozo, José Luis Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andres Pallarès, Natàlia Bergas, Alba Carratalà, Jordi Gudiol, Carlota on behalf of the IRONIC Study Group
dc.subject.other.pt_BR.fl_str_mv	Pseudomonas aeruginosa Infecção da corrente sanguínea Pneumonia Choque séptico Neutropenia
topic	Pseudomonas aeruginosa Infecção da corrente sanguínea Pneumonia Choque séptico Neutropenia Pseudomonas aeruginosa Bloodstream infection Pneumonia Septic shock Neutropenia
dc.subject.en.pt_BR.fl_str_mv	Pseudomonas aeruginosa Bloodstream infection Pneumonia Septic shock Neutropenia
description	Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain / Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III. Madri, Spain.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-08-12T13:32:25Z
dc.date.available.fl_str_mv	2022-08-12T13:32:25Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ALBASANZ-PUIG, Adaia et al. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganims, v. 10, 733, p. 1 - 14, Mar. 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/54622
dc.identifier.issn.pt_BR.fl_str_mv	2076-2607
dc.identifier.doi.none.fl_str_mv	10.3390/ microorganisms10040733
identifier_str_mv	ALBASANZ-PUIG, Adaia et al. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganims, v. 10, 733, p. 1 - 14, Mar. 2022. 2076-2607 10.3390/ microorganisms10040733
url	https://www.arca.fiocruz.br/handle/icict/54622
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/54622/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/54622/2/MarisaZR_Gomes_etal_IOC_2022.pdf
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 63c0992ad31e347fd0c0b1671adaf127
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

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