The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Freitas, Elisangela Oliveira de
Data de Publicação: 2016
Outros Autores: Leoratti, Fabiana Maria de Souza, Freire-de-Lima, Célio Geraldo, Morrot, Alexandre, Feijó, Daniel Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16250
Resumo: CNPq e FAPERJ
id CRUZ_1bd804309e955a49da1e249808cf341f
oai_identifier_str oai:www.arca.fiocruz.br:icict/16250
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Freitas, Elisangela Oliveira deLeoratti, Fabiana Maria de SouzaFreire-de-Lima, Célio GeraldoMorrot, AlexandreFeijó, Daniel Ferreira2016-10-14T18:13:47Z2016-10-14T18:13:47Z2016FREITAS, E. O. et al. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Frontiers in Immunology, v. 7, p. 1-7, 20161664-3224https://www.arca.fiocruz.br/handle/icict/1625010.3389/fimmu.2016.00153CNPq e FAPERJUniversity of Oxford. The Jenner Institute. Oxford, UKUniversity of Oxford. The Jenner Institute. Oxford, UKUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Laboratorio de Biologia do Sistema Imune. Instituto de Microbiologia. Departmento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilLeishmania is a genus of protozoan parasites that give rise to a range of diseases called Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries. Leishmania donovani and Leishmania (L.) infantum chagasi are responsible to cause the visceral leishmaniasis. The parasite can use assorted strategies to interfere with the host homeostasis to establish persistent infections that without treatment can be lethal. In this review, we highlight the mechanisms involved in the parasite subversion of the host protective immune response and how alterations of host tissue physiology and vascular remodeling during VL could affect the organ-specific immunity against Leishmania parasites.engFrontiers MediaLeishmanioseTratamentoLeishmania donovaniLeishmaniose VisceralMecanismos de evasão imuneProtozoáriosLeishmaniasisTreatmentLeishmania donovaniHost protective responsesImmune evasive mechanismsThe Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16250/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFreitas EO The contribution of immune....pdfFreitas EO The contribution of immune....pdfapplication/pdf180876https://www.arca.fiocruz.br/bitstream/icict/16250/2/Freitas%20EO%20The%20contribution%20of%20immune....pdfb436cd5f02b61a94684e792434a8f12dMD52TEXTFreitas EO The contribution of immune....pdf.txtFreitas EO The contribution of immune....pdf.txtExtracted texttext/plain44983https://www.arca.fiocruz.br/bitstream/icict/16250/3/Freitas%20EO%20The%20contribution%20of%20immune....pdf.txt030062638d30905bfa48d6bf42d25188MD53icict/162502023-03-15 14:33:58.259oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
title The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
spellingShingle The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
Freitas, Elisangela Oliveira de
Leishmaniose
Tratamento
Leishmania donovani
Leishmaniose Visceral
Mecanismos de evasão imune
Protozoários
Leishmaniasis
Treatment
Leishmania donovani
Host protective responses
Immune evasive mechanisms
title_short The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
title_full The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
title_fullStr The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
title_full_unstemmed The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
title_sort The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
author Freitas, Elisangela Oliveira de
author_facet Freitas, Elisangela Oliveira de
Leoratti, Fabiana Maria de Souza
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
Feijó, Daniel Ferreira
author_role author
author2 Leoratti, Fabiana Maria de Souza
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
Feijó, Daniel Ferreira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Elisangela Oliveira de
Leoratti, Fabiana Maria de Souza
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
Feijó, Daniel Ferreira
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Tratamento
Leishmania donovani
Leishmaniose Visceral
Mecanismos de evasão imune
Protozoários
topic Leishmaniose
Tratamento
Leishmania donovani
Leishmaniose Visceral
Mecanismos de evasão imune
Protozoários
Leishmaniasis
Treatment
Leishmania donovani
Host protective responses
Immune evasive mechanisms
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Treatment
Leishmania donovani
Host protective responses
Immune evasive mechanisms
description CNPq e FAPERJ
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-10-14T18:13:47Z
dc.date.available.fl_str_mv 2016-10-14T18:13:47Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, E. O. et al. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Frontiers in Immunology, v. 7, p. 1-7, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16250
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2016.00153
identifier_str_mv FREITAS, E. O. et al. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Frontiers in Immunology, v. 7, p. 1-7, 2016
1664-3224
10.3389/fimmu.2016.00153
url https://www.arca.fiocruz.br/handle/icict/16250
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16250/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16250/2/Freitas%20EO%20The%20contribution%20of%20immune....pdf
https://www.arca.fiocruz.br/bitstream/icict/16250/3/Freitas%20EO%20The%20contribution%20of%20immune....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
b436cd5f02b61a94684e792434a8f12d
030062638d30905bfa48d6bf42d25188
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009305892290560

Registros relacionados