Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection

Detalhes bibliográficos
Autor(a) principal: Souza, Robson da Paixão de
Data de Publicação: 2022
Outros Autores: Araújo, Maria Ilma, Lopes, Diego Mota, Oliveira, Sérgio Costa, Fernandes, Jamille Souza, Jesus, Kelvin Edson M. de, Carvalho, Edgar M, Oliveira, Ricardo Riccio, Cardoso, Luciana Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51689
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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spelling Souza, Robson da Paixão deAraújo, Maria IlmaLopes, Diego MotaOliveira, Sérgio CostaFernandes, Jamille SouzaJesus, Kelvin Edson M. deCarvalho, Edgar MOliveira, Ricardo RiccioCardoso, Luciana Santos2022-03-11T17:07:43Z2022-03-11T17:07:43Z2022Souza, Robson da Paixão de. et al. Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection. Parasitology Research, v. 121, p. 1-13, 2022.1432-1955https://www.arca.fiocruz.br/handle/icict/51689doi.org/10.1007/s00436-022-07435-5Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência E Tecnologia Em Doenças Tropicais. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Instituto Nacional de Ciência E Tecnologia Em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica E Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal Do Oeste da Bahia. Centro das Ciências Biológicas E da Saúde. Barreiras, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência E Tecnologia Em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência E Tecnologia Em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas E Toxicológicas. Salvador, BA, Brasil.Schistosoma mansoni still arouse great interest and controversy. Some authors demonstrate that resistance to infection is attributed to a mixed Th1 and Th2 response and resistance to reinfection after repeated treatments through mechanisms associated with the Th2 response. Through flow cytometry, the phenotypic characterization of B and T lymphocytes in individuals residing in endemic areas with low parasite loads over 10 years was evaluated for the first time in humans. In this study, individuals with low parasite loads for Schistosoma mansoni had a higher proportion of Th1 and Th2 cells. In addition, lymphocytes from these individuals showed a higher degree of expression of costimulatory molecules CD28 and CTLA-4 and regulatory molecules FoxP3 and IL-10, when compared to individuals with high parasite loads. Our data indicate that the control of the parasite load of S. mansoni must be associated with a Th1, Th2, and regulatory response, and that further studies are needed to elucidate the possibility of mechanisms associated with the hyporesponsiveness of lymphocytes from individuals with high parasite loads.engSpringerEsquistossomose mansoniLinfócitos TLinfócitos BEsquistossomoseSchistosomiasis mansoniT-LymphocytesB-LymphocytesSchistosomiasisEsquistosomiasis mansoniLinfocitos TLinfocitos BEsquistosomiasisSchistosomiase à Schistosoma mansonLymphocytes TLymphocytes BSchistosomiaseProfile of T and B lymphocytes in individuals resistant to schistosoma mansoni infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51689/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza, R da P de - Profile of T and B....pdfSouza, R da P de - Profile of T and B....pdfapplication/pdf1616443https://www.arca.fiocruz.br/bitstream/icict/51689/2/Souza%2c%20R%20da%20P%20de%20-%20Profile%20of%20T%20and%20B....pdf6a8b7c78f53c412495530b23fa729046MD52icict/516892023-03-15 14:33:25.478oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:25Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
title Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
spellingShingle Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
Souza, Robson da Paixão de
Esquistossomose mansoni
Linfócitos T
Linfócitos B
Esquistossomose
Schistosomiasis mansoni
T-Lymphocytes
B-Lymphocytes
Schistosomiasis
Esquistosomiasis mansoni
Linfocitos T
Linfocitos B
Esquistosomiasis
Schistosomiase à Schistosoma manson
Lymphocytes T
Lymphocytes B
Schistosomiase
title_short Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
title_full Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
title_fullStr Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
title_full_unstemmed Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
title_sort Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
author Souza, Robson da Paixão de
author_facet Souza, Robson da Paixão de
Araújo, Maria Ilma
Lopes, Diego Mota
Oliveira, Sérgio Costa
Fernandes, Jamille Souza
Jesus, Kelvin Edson M. de
Carvalho, Edgar M
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
author_role author
author2 Araújo, Maria Ilma
Lopes, Diego Mota
Oliveira, Sérgio Costa
Fernandes, Jamille Souza
Jesus, Kelvin Edson M. de
Carvalho, Edgar M
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Robson da Paixão de
Araújo, Maria Ilma
Lopes, Diego Mota
Oliveira, Sérgio Costa
Fernandes, Jamille Souza
Jesus, Kelvin Edson M. de
Carvalho, Edgar M
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
dc.subject.other.pt_BR.fl_str_mv Esquistossomose mansoni
Linfócitos T
Linfócitos B
Esquistossomose
topic Esquistossomose mansoni
Linfócitos T
Linfócitos B
Esquistossomose
Schistosomiasis mansoni
T-Lymphocytes
B-Lymphocytes
Schistosomiasis
Esquistosomiasis mansoni
Linfocitos T
Linfocitos B
Esquistosomiasis
Schistosomiase à Schistosoma manson
Lymphocytes T
Lymphocytes B
Schistosomiase
dc.subject.en.pt_BR.fl_str_mv Schistosomiasis mansoni
T-Lymphocytes
B-Lymphocytes
Schistosomiasis
dc.subject.es.pt_BR.fl_str_mv Esquistosomiasis mansoni
Linfocitos T
Linfocitos B
Esquistosomiasis
dc.subject.fr.pt_BR.fl_str_mv Schistosomiase à Schistosoma manson
Lymphocytes T
Lymphocytes B
Schistosomiase
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-11T17:07:43Z
dc.date.available.fl_str_mv 2022-03-11T17:07:43Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Souza, Robson da Paixão de. et al. Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection. Parasitology Research, v. 121, p. 1-13, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51689
dc.identifier.issn.pt_BR.fl_str_mv 1432-1955
dc.identifier.doi.none.fl_str_mv doi.org/10.1007/s00436-022-07435-5
identifier_str_mv Souza, Robson da Paixão de. et al. Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection. Parasitology Research, v. 121, p. 1-13, 2022.
1432-1955
doi.org/10.1007/s00436-022-07435-5
url https://www.arca.fiocruz.br/handle/icict/51689
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51689/1/license.txt
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