Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44665 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigac¸ão Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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Nisimura, L. M.Bousquet, P.Muccillo, F.Tibiricá, E.Garzoni, L. R.2020-11-27T19:38:54Z2020-11-27T19:38:54Z2020NISIMURA, L. M. et al. Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 53, n. 12, e9615, 2020.1414-431Xhttps://www.arca.fiocruz.br/handle/icict/4466510.1590/1414-431X20209615engAssociação Brasileira de Divulgação CientíficaAtaque Isquêmico TransitórioDoenças do Sistema Nervoso AutônomoLeucócitosClonidinaRatos Endogâmicos SHRBrain stemSympathetic nervous systemLeukocytesSpontaneously hypertensive ratsClonidineAtaque Isquêmico TransitórioDoenças do Sistema Nervoso AutônomoRatos Endogâmicos SHRTyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigac¸ão Cardiovascular. Rio de Janeiro, RJ, Brasil.University of Strasbourg. Faculty of Medicine. Department of Pharmacology. Strasbourg, France.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.The sympathetic nervous system (SNS) plays a fundamental role in the pathophysiology of cardiovascular diseases, including primary arterial hypertension. In this study, we aimed to investigate whether the expression of the rate-limiting enzyme in catecholamine synthesis, tyrosine hydroxylase (TH), and the b2-adrenergic receptor (b2-AR) in immune cells from peripheral blood, reflect central SNS activity in spontaneously hypertensive rats (SHR). TH expression in the lower brainstem and adrenal glands and b2-AR expression in the lower brainstem were analyzed by western blot analyses. In the leukocytes, TH and b2-AR expression was evaluated by flow cytometry before and after chronic treatment with the centrally-acting sympathoinhibitory drug clonidine. Western blot analyses showed increased TH and b2-AR expression in the lower brainstem and increased TH in adrenal glands from SHR compared to normotensive Wistar Kyoto rats (WKY). Lower brainstem from SHR treated with clonidine presented reduced TH and b2-AR levels, and adrenal glands had decreased TH expression compared to SHR treated with vehicle. Flow cytometry showed that the percentage of leukocytes that express b2-AR is higher in SHR than in WKY. However, the percentage of leukocytes that expressed TH was higher in WKY than in SHR. Moreover, chronic treatment with clonidine normalized the levels of TH and b2-AR in leukocytes from SHR to similar levels of those of WKY. Our study demonstrated that the percentage of leukocytes expressing TH and b2-AR was altered in arterial hypertension and can be modulated by central sympathetic inhibition with clonidine treatment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44665/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLMNisimura_ETibiriça_etal_IOC_2020.pdfLMNisimura_ETibiriça_etal_IOC_2020.pdfapplication/pdf737704https://www.arca.fiocruz.br/bitstream/icict/44665/2/LMNisimura_ETibiri%c3%a7a_etal_IOC_2020.pdf03311542397e3ccb35615003c2c8cba4MD52TEXTLMNisimura_ETibiriça_etal_IOC_2020.pdf.txtLMNisimura_ETibiriça_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
title |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
spellingShingle |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity Nisimura, L. M. Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Leucócitos Clonidina Ratos Endogâmicos SHR Brain stem Sympathetic nervous system Leukocytes Spontaneously hypertensive rats Clonidine Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Ratos Endogâmicos SHR |
title_short |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
title_full |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
title_fullStr |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
title_full_unstemmed |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
title_sort |
Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity |
author |
Nisimura, L. M. |
author_facet |
Nisimura, L. M. Bousquet, P. Muccillo, F. Tibiricá, E. Garzoni, L. R. |
author_role |
author |
author2 |
Bousquet, P. Muccillo, F. Tibiricá, E. Garzoni, L. R. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nisimura, L. M. Bousquet, P. Muccillo, F. Tibiricá, E. Garzoni, L. R. |
dc.subject.other.pt_BR.fl_str_mv |
Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Leucócitos Clonidina Ratos Endogâmicos SHR |
topic |
Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Leucócitos Clonidina Ratos Endogâmicos SHR Brain stem Sympathetic nervous system Leukocytes Spontaneously hypertensive rats Clonidine Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Ratos Endogâmicos SHR |
dc.subject.en.pt_BR.fl_str_mv |
Brain stem Sympathetic nervous system Leukocytes Spontaneously hypertensive rats Clonidine |
dc.subject.decs.pt_BR.fl_str_mv |
Ataque Isquêmico Transitório Doenças do Sistema Nervoso Autônomo Ratos Endogâmicos SHR |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigac¸ão Cardiovascular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-11-27T19:38:54Z |
dc.date.available.fl_str_mv |
2020-11-27T19:38:54Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NISIMURA, L. M. et al. Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 53, n. 12, e9615, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44665 |
dc.identifier.issn.pt_BR.fl_str_mv |
1414-431X |
dc.identifier.doi.none.fl_str_mv |
10.1590/1414-431X20209615 |
identifier_str_mv |
NISIMURA, L. M. et al. Tyrosine hydroxylase and b2-adrenergic receptor expression in leukocytes of spontaneously hypertensive rats: putative peripheral markers of central sympathetic activity. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 53, n. 12, e9615, 2020. 1414-431X 10.1590/1414-431X20209615 |
url |
https://www.arca.fiocruz.br/handle/icict/44665 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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Repositório Institucional da FIOCRUZ (ARCA) |
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