Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36096 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. |
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Meirelles, Maria de Nazareth Leal dePereira, Mirian Claudia S.Singer, Robert H.Soeiro, Maria de Nazaré C.Garzoni, Luciana R.Silva, Dayse T.Barbosa, Helene S.Araujo-Jorge, Tania C.Masuda, Masako O.Capella, Marcia A. M.Lopes, Anibal GilVermelho, Alane B.2019-10-02T15:25:59Z2019-10-02T15:25:59Z1999MEIRELLES, Maria de Nazareth Leal de et al. Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl. I, p. 149-152, 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/3609610.1590/S0074-027619990007000171678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosoma cruziCálcioCardiomiócitosmRNA regulaçãoTrypanosoma cruziCardiomyocytesCalciumSERGA ATPasesMannose receptormRNA regulationTrypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interactioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Eletrofisiologia Cardíaca. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Fisiologia Renal. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Fisiologia Renal. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Rio de Janeiro, RJ, Brasil.The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of the parasite. One of the most striking events in the parasite-heart muscle cells interaction is the disruption of the actin cytoskeleton. We have investigated the regulation of the actin mRNA during the cytopathology induced in myocardial cells by the parasite. T. cruzi invasion increases calcium resting levels in cardiomyocytes. We have previously shown that Ca2+ ATPase of the sarcoplasmic reticulum (SERCA) is involved in the invasion of T. cruzi in cardiomyocytes. Treating the cells with thapsigargin, a drug that binds to all SERCA ATPases and causes depletion of intracellular calcium stores, we found a 75% inhibition in the T. cruzi-cardiomyocytes invasion.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36096/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaNSoeiro_HeleneBarbosa_etal_IOC_1999.pdfMariaNSoeiro_HeleneBarbosa_etal_IOC_1999.pdfapplication/pdf48613https://www.arca.fiocruz.br/bitstream/icict/36096/2/MariaNSoeiro_HeleneBarbosa_etal_IOC_1999.pdf23ab5d737604166542604bc4d3950826MD52TEXTMariaNSoeiro_HeleneBarbosa_etal_IOC_1999.pdf.txtMariaNSoeiro_HeleneBarbosa_etal_IOC_1999.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| title |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| spellingShingle |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction Meirelles, Maria de Nazareth Leal de Trypanosoma cruzi Cálcio Cardiomiócitos mRNA regulação Trypanosoma cruzi Cardiomyocytes Calcium SERGA ATPases Mannose receptor mRNA regulation |
| title_short |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| title_full |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| title_fullStr |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| title_full_unstemmed |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| title_sort |
Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction |
| author |
Meirelles, Maria de Nazareth Leal de |
| author_facet |
Meirelles, Maria de Nazareth Leal de Pereira, Mirian Claudia S. Singer, Robert H. Soeiro, Maria de Nazaré C. Garzoni, Luciana R. Silva, Dayse T. Barbosa, Helene S. Araujo-Jorge, Tania C. Masuda, Masako O. Capella, Marcia A. M. Lopes, Anibal Gil Vermelho, Alane B. |
| author_role |
author |
| author2 |
Pereira, Mirian Claudia S. Singer, Robert H. Soeiro, Maria de Nazaré C. Garzoni, Luciana R. Silva, Dayse T. Barbosa, Helene S. Araujo-Jorge, Tania C. Masuda, Masako O. Capella, Marcia A. M. Lopes, Anibal Gil Vermelho, Alane B. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Meirelles, Maria de Nazareth Leal de Pereira, Mirian Claudia S. Singer, Robert H. Soeiro, Maria de Nazaré C. Garzoni, Luciana R. Silva, Dayse T. Barbosa, Helene S. Araujo-Jorge, Tania C. Masuda, Masako O. Capella, Marcia A. M. Lopes, Anibal Gil Vermelho, Alane B. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Cálcio Cardiomiócitos mRNA regulação |
| topic |
Trypanosoma cruzi Cálcio Cardiomiócitos mRNA regulação Trypanosoma cruzi Cardiomyocytes Calcium SERGA ATPases Mannose receptor mRNA regulation |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Cardiomyocytes Calcium SERGA ATPases Mannose receptor mRNA regulation |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. |
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1999 |
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1999 |
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2019-10-02T15:25:59Z |
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2019-10-02T15:25:59Z |
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MEIRELLES, Maria de Nazareth Leal de et al. Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl. I, p. 149-152, 1999. |
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https://www.arca.fiocruz.br/handle/icict/36096 |
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0074-0276 |
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10.1590/S0074-02761999000700017 |
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1678-8060 |
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MEIRELLES, Maria de Nazareth Leal de et al. Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl. I, p. 149-152, 1999. 0074-0276 10.1590/S0074-02761999000700017 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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