Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35197 |
Resumo: | Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Azevedo, Luciano C. P.Caruso, PedroSilva, Ulysses V. A.Torelly, André P.Silva, EliézerRezende, EderlonNetto, José J.Piras, ClaudioLobo, Suzana M. A.Knibel, Marcos F.Teles, José M.Lima, Ricardo A.Ferreira, Bruno S.Friedman, GilbertoRea-Neto, AlvaroDal-Pizzol, FelipeBozza, Fernando A.Salluh, Jorge I. F.Soares, Márcio2019-08-29T14:54:51Z2019-08-29T14:54:51Z2014AZEVEDO, Luciano C. P. et al. Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study. Chest, v. 146, n. 2, p. 257-266, 2014.0012-3692https://www.arca.fiocruz.br/handle/icict/3519710.1378/chest.13-18701931-3543Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-08-29Hospital Sirio-Libanes. ICU. São Paulo, SP, Brazil / Instituto Nacional de Câncer. Hospital do Câncer II. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil.Hospital A. C. Camargo. ICU. São Paulo, SP, Brazil.Fundação Pio XII. Hospital do Câncer de Barretos. Barretos, SP, Brasil.Santa Casa de Misericórdia de Porto Alegre. ICU. Porto Alegre, RS, Brazil.Hospital Israelita Albert Einstein. ICU. São Paulo, SP, Brazil.Hospital do Servidor Público Estadual. ICU. São Paulo, SP, Brazil.Instituto Nacional de Câncer. Hospital do Câncer II. ICU. Rio de Janeiro, RJ, Brasil.Vitória Apart Hospital. ICU. Vitória, ES, Brazil.Faculdade de Medicina de São José do Rio Preto. Medical School. Department of Internal Medicine. São José do Rio Preto, SP, Brazil / Hospital de Base. Division of Critical Care. Medicine. São José do Rio Preto, SP, Brazil.Hospital São Lucas. ICU. Rio de Janeiro, RJ, Brazil.Hospital Português. ICU. Salvador, BA, Brazil.Hospital Samaritano. ICU. Rio de Janeiro, RJ, Brazil.Hospital Pasteur. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. ICU. Porto Alegre, RS, Brazil.Universidade Federal do Paraná. Hospital de Clínicas. ICU. Curitiba. PR, Brazil.Universidade do Extremo Sul Catarinense. Unidade Acadêmica de Ciências da Saúde. Programa de Pós-Graduação Ciências da Saúde. Criciúma, SC, Brasil.D’Or Institute for Research and Education. ICU. Rio de Janeiro, RJ, Brazil.Instituto Nacional de Câncer. Hospital do Câncer II. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / D’Or Institute for Research and Education. ICU. Rio de Janeiro, RJ, Brazil.Instituto Nacional de Câncer. Hospital do Câncer II. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / D’Or Institute for Research and Education. ICU. Rio de Janeiro, RJ, Brazil.BACKGROUND: This study was undertaken to evaluate the clinical characteristics and outcomes of patients with cancer requiring nonpalliative ventilatory support. METHODS: This was a secondary analysis of a prospective cohort study conducted in 28 Brazilian ICUs evaluating adult patients with cancer requiring invasive mechanical ventilation (MV) or noninvasive ventilation (NIV) during the first 48h of their ICU stay. We used logistic regression to identify the variables associated with hospital mortality. RESULTS: Of 717 patients, 263 (37%) (solid tumors = 227; hematologic malignancies = 36) received ventilatory support. NIV was initially used in 85 patients (32%), and 178 (68%) received MV. Additionally, NIV followed by MV occurred in 45 patients (53%). Hospital mortality rates were 67% in all patients, 40% in patients receiving NIV only, 69% when NIV was followed by MV, and 73% in patients receiving MV only (P<.001). Adjusting for the type of admission, newly diagnosed malignancy (OR, 3.59; 95% CI, 1.28-10.10), recurrent or progressive malignancy (OR, 3.67; 95% CI, 1.25-10.81), tumoral airway involvement (OR, 4.04; 95% CI, 1.30-12.56), performance status (PS) 2 to 4 (OR, 2.39; 95% CI, 1.24-4.59), NIV fol-lowed by MV (OR, 3.00; 95% CI, 1.09-8.18), MV as initial ventilatory strategy (OR, 3.53; 95% CI, 1.45-8.60), and Sequential Organ Failure Assessment score (each point except the respiratory domain) (OR, 1.15; 95% CI, 1.03-1.29) were associated with hospital mortality. Hospital survival in patients with good PS and nonprogressive malignancy and without tumoral airway involvement was 53%. Conversely, patients with poor functional capacity and cancer progres-sion had unfavorable outcomes. CONCLUSIONS: Patients with cancer with good PS and nonprogressive disease requiring ventilatory support should receive full intensive care, because one-half of these patients survive. On the other hand, provision of palliative care should be considered the main goal for patients with poor PS and progressive underlying malignancy.engElsevierOutcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePatients with cancerVentilatory supportICUinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| title |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| spellingShingle |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study Azevedo, Luciano C. P. Patients with cancer Ventilatory support ICU |
| title_short |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| title_full |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| title_fullStr |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| title_full_unstemmed |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| title_sort |
Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study |
| author |
Azevedo, Luciano C. P. |
| author_facet |
Azevedo, Luciano C. P. Caruso, Pedro Silva, Ulysses V. A. Torelly, André P. Silva, Eliézer Rezende, Ederlon Netto, José J. Piras, Claudio Lobo, Suzana M. A. Knibel, Marcos F. Teles, José M. Lima, Ricardo A. Ferreira, Bruno S. Friedman, Gilberto Rea-Neto, Alvaro Dal-Pizzol, Felipe Bozza, Fernando A. Salluh, Jorge I. F. Soares, Márcio |
| author_role |
author |
| author2 |
Caruso, Pedro Silva, Ulysses V. A. Torelly, André P. Silva, Eliézer Rezende, Ederlon Netto, José J. Piras, Claudio Lobo, Suzana M. A. Knibel, Marcos F. Teles, José M. Lima, Ricardo A. Ferreira, Bruno S. Friedman, Gilberto Rea-Neto, Alvaro Dal-Pizzol, Felipe Bozza, Fernando A. Salluh, Jorge I. F. Soares, Márcio |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Azevedo, Luciano C. P. Caruso, Pedro Silva, Ulysses V. A. Torelly, André P. Silva, Eliézer Rezende, Ederlon Netto, José J. Piras, Claudio Lobo, Suzana M. A. Knibel, Marcos F. Teles, José M. Lima, Ricardo A. Ferreira, Bruno S. Friedman, Gilberto Rea-Neto, Alvaro Dal-Pizzol, Felipe Bozza, Fernando A. Salluh, Jorge I. F. Soares, Márcio |
| dc.subject.en.pt_BR.fl_str_mv |
Patients with cancer Ventilatory support ICU |
| topic |
Patients with cancer Ventilatory support ICU |
| description |
Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2014 |
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2014 |
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2019-08-29T14:54:51Z |
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2019-08-29T14:54:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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AZEVEDO, Luciano C. P. et al. Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study. Chest, v. 146, n. 2, p. 257-266, 2014. |
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https://www.arca.fiocruz.br/handle/icict/35197 |
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0012-3692 |
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10.1378/chest.13-1870 |
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1931-3543 |
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AZEVEDO, Luciano C. P. et al. Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study. Chest, v. 146, n. 2, p. 257-266, 2014. 0012-3692 10.1378/chest.13-1870 1931-3543 |
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Elsevier |
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Elsevier |
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