Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review

Detalhes bibliográficos
Autor(a) principal: Duarte, Beatriz Barreto
Data de Publicação: 2021
Outros Autores: Gomes, Fabiana H. Andrade, rriaga, Marıa B. A, Pereira, Mariana Araújo, Cubillos-Angulo, Juan Manuel, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/ journal.pone.0241096
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46294
Resumo: Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (CNPq). B.B-D received a research fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES, finance code: 001). M.B.A received a fellowship from the Fundac¸ão de Amparo à Pesquisa da Bahia (FAPESB). MAP received a fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES). J.M.C-A was supported by the Organization of American States - Partner-ships Program for Education and Training (OAS-PAEC) and his study was financed in part by the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior - Brazil (CAPES) - Finance Code 001.
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spelling Duarte, Beatriz BarretoGomes, Fabiana H. Andraderriaga, Marıa B. APereira, Mariana AraújoCubillos-Angulo, Juan ManuelAndrade, Bruno de Bezerril2021-03-08T13:39:40Z2021-03-08T13:39:40Z2021DUARTE, Beatriz Barreto et al. Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review. Plos One, 2021.1932-6203https://www.arca.fiocruz.br/handle/icict/4629410.1371/ journal.pone.0241096Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (CNPq). B.B-D received a research fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES, finance code: 001). M.B.A received a fellowship from the Fundac¸ão de Amparo à Pesquisa da Bahia (FAPESB). MAP received a fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES). J.M.C-A was supported by the Organization of American States - Partner-ships Program for Education and Training (OAS-PAEC) and his study was financed in part by the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior - Brazil (CAPES) - Finance Code 001.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil.Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Neurofibromatosis type 1 (NF-1) is an autosomal dominant disease that affects one in every 3000 individuals. This disease can present a wide range of clinical manifestations, ranging from skin abnormalities to severe vascular damage. Although not commonly recognized in the context of NF-1, cerebrovascular disease (CVD), can be often present since childhood and diagnosed just later in life. When present, NF-1-associated CVD clinical manifestations may include headache, cognitive deficits and ultimately aneurysm rupture, causing death. Thus, CVD plays an important role in the clinical manifestations, disease severity and prognosis of patients with NF-1. This systematic review aims to summarize the body of evidence linking NF-1 and CVD in children. Methods Two independent investigators performed a systematic review on the PubMed and EMBASE search platforms, using the following key terms: “neurofibromatosis type 1”, “Von Recklinghausen’s disease”, "children", "adolescents", "stroke", "Moyamoya disease", "vascular diseases", "cerebrovascular disorders", "aneurysm" and "congenital abnormalities". Studies focused on assessing the development of CVD in children with NF-1 were included. Results Seven studies met the inclusion criteria. Twelve different clinical manifestations have been associated with cerebrovascular changes in children with NF-1; 44,5% of diagnosed patients were asymptomatic. The available evidence suggests that CVDs are related with the progression of NF-1, even in the absence of a clear clinical manifestation. In addition, improved prognosis was observed when imaging tests were performed to screen for cerebrovascular alterations early during the clinical investigation. Early diagnosis of CVD in NF-1 patients foster implementation of timely interventions, directly impacting clinical outcomes.engPublic Library of ScienceNeurofibromatosesCriançaAcidente Vascular CerebralRevisão SistemáticaTranstornos CerebrovascularesNeurofibromatosisChildrenStrokeSystematic reviewCerebrovascular DisordersAssociation between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46294/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALDuarte, Barreto Beatriz. Association between... (1).pdfDuarte, Barreto Beatriz. Association between... 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dc.title.pt_BR.fl_str_mv Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
title Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
spellingShingle Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
Duarte, Beatriz Barreto
Neurofibromatoses
Criança
Acidente Vascular Cerebral
Revisão Sistemática
Transtornos Cerebrovasculares
Neurofibromatosis
Children
Stroke
Systematic review
Cerebrovascular Disorders
title_short Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
title_full Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
title_fullStr Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
title_full_unstemmed Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
title_sort Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review
author Duarte, Beatriz Barreto
author_facet Duarte, Beatriz Barreto
Gomes, Fabiana H. Andrade
rriaga, Marıa B. A
Pereira, Mariana Araújo
Cubillos-Angulo, Juan Manuel
Andrade, Bruno de Bezerril
author_role author
author2 Gomes, Fabiana H. Andrade
rriaga, Marıa B. A
Pereira, Mariana Araújo
Cubillos-Angulo, Juan Manuel
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Duarte, Beatriz Barreto
Gomes, Fabiana H. Andrade
rriaga, Marıa B. A
Pereira, Mariana Araújo
Cubillos-Angulo, Juan Manuel
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Neurofibromatoses
Criança
Acidente Vascular Cerebral
Revisão Sistemática
Transtornos Cerebrovasculares
topic Neurofibromatoses
Criança
Acidente Vascular Cerebral
Revisão Sistemática
Transtornos Cerebrovasculares
Neurofibromatosis
Children
Stroke
Systematic review
Cerebrovascular Disorders
dc.subject.en.pt_BR.fl_str_mv Neurofibromatosis
Children
Stroke
Systematic review
Cerebrovascular Disorders
description Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico (CNPq). B.B-D received a research fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES, finance code: 001). M.B.A received a fellowship from the Fundac¸ão de Amparo à Pesquisa da Bahia (FAPESB). MAP received a fellowship from the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior (CAPES). J.M.C-A was supported by the Organization of American States - Partner-ships Program for Education and Training (OAS-PAEC) and his study was financed in part by the Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nı´vel Superior - Brazil (CAPES) - Finance Code 001.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-08T13:39:40Z
dc.date.available.fl_str_mv 2021-03-08T13:39:40Z
dc.date.issued.fl_str_mv 2021
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dc.identifier.citation.fl_str_mv DUARTE, Beatriz Barreto et al. Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review. Plos One, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46294
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/ journal.pone.0241096
identifier_str_mv DUARTE, Beatriz Barreto et al. Association between neurofibromatosis type 1 and cerebrovascular diseases in children: A systematic review. Plos One, 2021.
1932-6203
10.1371/ journal.pone.0241096
url https://www.arca.fiocruz.br/handle/icict/46294
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