Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node

Detalhes bibliográficos
Autor(a) principal: Aggio, Juliana Bernardi
Data de Publicação: 2021
Outros Autores: Krmeska, Veronika, Ferguson, Brian J., Wowk, Pryscilla Fanini, Rothfuchs, Antonio Gigliotti
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46354
https://doi.org/10.4049/jimmunol.2000928
Resumo: Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
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spelling Aggio, Juliana BernardiKrmeska, VeronikaFerguson, Brian J.Wowk, Pryscilla FaniniRothfuchs, Antonio Gigliotti2021-03-12T18:49:54Z2021-03-12T18:49:54Z2021AGGIO, Juliana Bernardi et al. Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node. The Journal of Immunology, p. 776-784, 2021.1550-6606https://www.arca.fiocruz.br/handle/icict/46354https://doi.org/10.4049/jimmunol.2000928porThe American Association of ImmunologistsBacillus Calmette-GuérinBCGVaccinia virusDendritic CellsLymph NodesCD4-Positive T-LymphocytesVirus VacciniaCélulas DendríticasGanglios LinfáticosLinfocitos T CD4-PositivosVirus de la vaccineCellules dendritiquesNoeuds lymphatiquesLymphocytes T CD4+Vírus VacciniaCélulas DendríticasMycobacterium bovisLinfonodosLinfócitos T CD4-PositivosVaccinia virus infection inhibits skin dendritic cell migration to the draining lymph nodeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleKarolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden.Department of Pathology. University of Cambridge. Cambridge, United Kingdom.Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden.There is a paucity of information on dendritic cell (DC) responses to vaccinia virus (VACV), including the traffic of DCs to the draining lymph node (dLN). In this study, using a mouse model of infection, we studied skin DC migration in response to VACV and compared it with the tuberculosis vaccine Mycobacterium bovis bacille Calmette–Gue´rin (BCG), another live attenuated vaccine administered via the skin. In stark contrast to BCG, skin DCs did not relocate to the dLN in response to VACV. Infection with UV-inactivated VACV or modified VACVAnkara promoted DC movement to the dLN, indicating that interference with skin DC migration requires replication-competent VACV. This suppressive effect of VACV was capable of mitigating responses to a secondary challenge with BCG in the skin, ablating DC migration, reducing BCG transport, and delaying CD4+ T cell priming in the dLN. Expression of inflammatory mediators associated with BCG-triggered DC migration were absent from virus-injected skin, suggesting that other pathways invoke DC movement in response to replication-deficient VACV. Despite adamant suppression of DC migration, VACV was still detected early in the dLN and primed Ag-specific CD4+ T cells. In summary, VACV blocks skin DC mobilization from the site of infection while retaining the ability to access the dLN to prime CD4+ T cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/46354/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALji2000928ok.pdfji2000928ok.pdfapplication/pdf983689https://www.arca.fiocruz.br/bitstream/icict/46354/2/ji2000928ok.pdf5107797cab2b1eeb030908df84958e73MD52TEXTji2000928ok.pdf.txtji2000928ok.pdf.txtExtracted texttext/plain49874https://www.arca.fiocruz.br/bitstream/icict/46354/3/ji2000928ok.pdf.txtb19b7cda1ffdbe47af44c182bf198276MD53icict/463542021-03-13 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dc.title.pt_BR.fl_str_mv Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
title Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
spellingShingle Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
Aggio, Juliana Bernardi
Bacillus Calmette-Guérin
BCG
Vaccinia virus
Dendritic Cells
Lymph Nodes
CD4-Positive T-Lymphocytes
Virus Vaccinia
Células Dendríticas
Ganglios Linfáticos
Linfocitos T CD4-Positivos
Virus de la vaccine
Cellules dendritiques
Noeuds lymphatiques
Lymphocytes T CD4+
Vírus Vaccinia
Células Dendríticas
Mycobacterium bovis
Linfonodos
Linfócitos T CD4-Positivos
title_short Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
title_full Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
title_fullStr Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
title_full_unstemmed Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
title_sort Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
author Aggio, Juliana Bernardi
author_facet Aggio, Juliana Bernardi
Krmeska, Veronika
Ferguson, Brian J.
Wowk, Pryscilla Fanini
Rothfuchs, Antonio Gigliotti
author_role author
author2 Krmeska, Veronika
Ferguson, Brian J.
Wowk, Pryscilla Fanini
Rothfuchs, Antonio Gigliotti
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Aggio, Juliana Bernardi
Krmeska, Veronika
Ferguson, Brian J.
Wowk, Pryscilla Fanini
Rothfuchs, Antonio Gigliotti
dc.subject.other.pt_BR.fl_str_mv Bacillus Calmette-Guérin
BCG
topic Bacillus Calmette-Guérin
BCG
Vaccinia virus
Dendritic Cells
Lymph Nodes
CD4-Positive T-Lymphocytes
Virus Vaccinia
Células Dendríticas
Ganglios Linfáticos
Linfocitos T CD4-Positivos
Virus de la vaccine
Cellules dendritiques
Noeuds lymphatiques
Lymphocytes T CD4+
Vírus Vaccinia
Células Dendríticas
Mycobacterium bovis
Linfonodos
Linfócitos T CD4-Positivos
dc.subject.en.pt_BR.fl_str_mv Vaccinia virus
Dendritic Cells
Lymph Nodes
CD4-Positive T-Lymphocytes
dc.subject.es.pt_BR.fl_str_mv Virus Vaccinia
Células Dendríticas
Ganglios Linfáticos
Linfocitos T CD4-Positivos
dc.subject.fr.pt_BR.fl_str_mv Virus de la vaccine
Cellules dendritiques
Noeuds lymphatiques
Lymphocytes T CD4+
dc.subject.decs.pt_BR.fl_str_mv Vírus Vaccinia
Células Dendríticas
Mycobacterium bovis
Linfonodos
Linfócitos T CD4-Positivos
description Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-12T18:49:54Z
dc.date.available.fl_str_mv 2021-03-12T18:49:54Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AGGIO, Juliana Bernardi et al. Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node. The Journal of Immunology, p. 776-784, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46354
dc.identifier.issn.pt_BR.fl_str_mv 1550-6606
dc.identifier.doi.none.fl_str_mv https://doi.org/10.4049/jimmunol.2000928
identifier_str_mv AGGIO, Juliana Bernardi et al. Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node. The Journal of Immunology, p. 776-784, 2021.
1550-6606
url https://www.arca.fiocruz.br/handle/icict/46354
https://doi.org/10.4049/jimmunol.2000928
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The American Association of Immunologists
publisher.none.fl_str_mv The American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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