Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization

Detalhes bibliográficos
Autor(a) principal: Aliberti, Julio
Data de Publicação: 2003
Outros Autores: Viola, João P. B., Abreu, Adriana Vieira de, Bozza, Patrícia T., Sher, Alan, Scharfstein, Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40906
Resumo: Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/170/11/5349.full.pdf
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spelling Aliberti, JulioViola, João P. B.Abreu, Adriana Vieira deBozza, Patrícia T.Sher, AlanScharfstein, Julio2020-04-21T15:57:57Z2020-04-21T15:57:57Z2003ALIBERTI, Julio et al. Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization. Journal of Immunology, v. 170, p. 5349-5353, 2003.0022-1767https://www.arca.fiocruz.br/handle/icict/4090610.4049/jimmunol.170.11.53491550-6606Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/170/11/5349.full.pdfNational Institutes of Health. National Institute of Allergy and Infectious Disease. Immunobiology Section. Bethesda, MD, USA.Instituto Nacional de Câncer. Divisâo de Medicina Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Disease. Immunobiology Section. Bethesda, MD, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Dendritic cells play a major role in the induction of both innate and acquired immune responses against pathogenic invaders. These cells are also able to sense endogenous activation signals liberated by injured tissues even in the absence of infection. In the present work, we demonstrate that kinins mobilize dendritic cells to produce IL-12 through activation of the B(2) bradykinin receptor subtype and that bradykinin-induced IL-12 responses are tightly regulated both by angiotensin-converting enzyme, a kinin-degrading peptidase, and by endogenous IL-10. Using a mouse model of allergic inflammation, we further show that addition of bradykinin to OVA during immunization results in decreased eosinophil infiltration on Ag challenge. The latter effect was demonstrated to be due to IL-12-driven skewing of Ag-specific T cell responses to a type 1 cytokine profile. Our data thus indicate that kinin peptides can serve as danger signals that trigger dendritic cells to produce IL-12 through activation of B(2) bradykinin receptors.engAmerican Association of ImmunologistsBradykininProdução de IL-12Células DendríticasTh1 PolarizaçãoBradykininDendritic CellsTh1 PolarizationIL-12 ProductionCutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
title Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
spellingShingle Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
Aliberti, Julio
Bradykinin
Produção de IL-12
Células Dendríticas
Th1 Polarização
Bradykinin
Dendritic Cells
Th1 Polarization
IL-12 Production
title_short Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
title_full Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
title_fullStr Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
title_full_unstemmed Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
title_sort Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization
author Aliberti, Julio
author_facet Aliberti, Julio
Viola, João P. B.
Abreu, Adriana Vieira de
Bozza, Patrícia T.
Sher, Alan
Scharfstein, Julio
author_role author
author2 Viola, João P. B.
Abreu, Adriana Vieira de
Bozza, Patrícia T.
Sher, Alan
Scharfstein, Julio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Aliberti, Julio
Viola, João P. B.
Abreu, Adriana Vieira de
Bozza, Patrícia T.
Sher, Alan
Scharfstein, Julio
dc.subject.other.pt_BR.fl_str_mv Bradykinin
Produção de IL-12
Células Dendríticas
Th1 Polarização
topic Bradykinin
Produção de IL-12
Células Dendríticas
Th1 Polarização
Bradykinin
Dendritic Cells
Th1 Polarization
IL-12 Production
dc.subject.en.pt_BR.fl_str_mv Bradykinin
Dendritic Cells
Th1 Polarization
IL-12 Production
description Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/170/11/5349.full.pdf
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2020-04-21T15:57:57Z
dc.date.available.fl_str_mv 2020-04-21T15:57:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALIBERTI, Julio et al. Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization. Journal of Immunology, v. 170, p. 5349-5353, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40906
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.170.11.5349
dc.identifier.eissn.none.fl_str_mv 1550-6606
identifier_str_mv ALIBERTI, Julio et al. Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization. Journal of Immunology, v. 170, p. 5349-5353, 2003.
0022-1767
10.4049/jimmunol.170.11.5349
1550-6606
url https://www.arca.fiocruz.br/handle/icict/40906
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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