Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study

Detalhes bibliográficos
Autor(a) principal: Paixão, Enny Santos da
Data de Publicação: 2017
Outros Autores: Costa, Maria da Conceição Nascimento, Teixeira, Maria Glória Lima Cruz, Harron, Katie, Almeida, Marcia Furquim de, Barreto, Maurício Lima, Rodrigues, Laura Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25499
Resumo: Brazilian National Council for Scientific and Technological Development, Horizon 2020
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spelling Paixão, Enny Santos daCosta, Maria da Conceição NascimentoTeixeira, Maria Glória Lima CruzHarron, KatieAlmeida, Marcia Furquim deBarreto, Maurício LimaRodrigues, Laura Cunha2018-03-26T18:58:28Z2018-03-26T18:58:28Z2017PAIXÃO, Enny Santos da et al. Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study. Lancet Infectious Diseases, v. 17, p. 957–964, 2017.1473-3099https://www.arca.fiocruz.br/handle/icict/2549910.1016/S1473-3099(17)30366-3Brazilian National Council for Scientific and Technological Development, Horizon 2020London School of Hygiene & Tropical Medicine. London, UK / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. Salvador, BA, Brasil.London School of Hygiene & Tropical Medicine. London, UK.Universidade de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. Salvador, BA, Brasil / Universidade de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. Salvador, BA, Brasil.Background Maternal infections during pregnancy can increase the risk of fetal death. Dengue infection is common, but little is known about its role in fetal mortality. We aimed to investigate the association between symptomatic dengue infection during pregnancy and fetal death. Methods We did a nested case-control study using obstetrician-collected data from the Brazilian livebirth information system (SINASC), the mortality information system (SIM), and the national reportable disease information system (SINAN). We identified all pregnancies ending in stillbirth and a random sample of livebirths between Jan 1, 2006, and Dec 31, 2012. We did linkage to determine which mothers were diagnosed with dengue infection during pregnancy. By use of stillbirths as cases and a sample of matched livebirths as a control, we calculated matched odds ratios (mORs) using conditional logistic regression adjusted for maternal age and education. Findings 275 (0·2%) of 162 188 women who had stillbirths and 1507 (0·1%) of 1 586 105 women who had livebirths were diagnosed with dengue infection during pregnancy. Symptomatic dengue infection during pregnancy almost doubled the odds of fetal death (mOR 1·9, 95% CI 1·6–2·2). The increase in risk was similar when analyses were restricted to laboratory-confirmed cases of dengue infection (1·8, 1·4–2·4). Severe dengue infection increased the risk of fetal death by about five times (4·9, 2·3–10·2). Interpretation Symptomatic dengue infection during pregnancy is associated with an increased risk of fetal death. We recommend further epidemiological and biological studies of the association between dengue and poor birth outcomes to measure the burden of subclinical infections and elucidate pathological mechanisms.engElsevierDengueInfecção pelo Vírus da DengueGravidezMorte fetalFatores de riscoHumanosFemininoNatimortosDengueDengue Virus InfectionPregnancyFetal deathRisk factorsHumansFemaleStillbirthsSymptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25499/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPaixão ES Symptomatic dengue infection during pregnancy....pdfPaixão ES Symptomatic dengue infection during 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dc.title.pt_BR.fl_str_mv Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
title Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
spellingShingle Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
Paixão, Enny Santos da
Dengue
Infecção pelo Vírus da Dengue
Gravidez
Morte fetal
Fatores de risco
Humanos
Feminino
Natimortos
Dengue
Dengue Virus Infection
Pregnancy
Fetal death
Risk factors
Humans
Female
Stillbirths
title_short Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
title_full Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
title_fullStr Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
title_full_unstemmed Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
title_sort Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
author Paixão, Enny Santos da
author_facet Paixão, Enny Santos da
Costa, Maria da Conceição Nascimento
Teixeira, Maria Glória Lima Cruz
Harron, Katie
Almeida, Marcia Furquim de
Barreto, Maurício Lima
Rodrigues, Laura Cunha
author_role author
author2 Costa, Maria da Conceição Nascimento
Teixeira, Maria Glória Lima Cruz
Harron, Katie
Almeida, Marcia Furquim de
Barreto, Maurício Lima
Rodrigues, Laura Cunha
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paixão, Enny Santos da
Costa, Maria da Conceição Nascimento
Teixeira, Maria Glória Lima Cruz
Harron, Katie
Almeida, Marcia Furquim de
Barreto, Maurício Lima
Rodrigues, Laura Cunha
dc.subject.other.pt_BR.fl_str_mv Dengue
Infecção pelo Vírus da Dengue
Gravidez
Morte fetal
Fatores de risco
Humanos
Feminino
Natimortos
topic Dengue
Infecção pelo Vírus da Dengue
Gravidez
Morte fetal
Fatores de risco
Humanos
Feminino
Natimortos
Dengue
Dengue Virus Infection
Pregnancy
Fetal death
Risk factors
Humans
Female
Stillbirths
dc.subject.en.pt_BR.fl_str_mv Dengue
Dengue Virus Infection
Pregnancy
Fetal death
Risk factors
Humans
Female
Stillbirths
description Brazilian National Council for Scientific and Technological Development, Horizon 2020
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-26T18:58:28Z
dc.date.available.fl_str_mv 2018-03-26T18:58:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAIXÃO, Enny Santos da et al. Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study. Lancet Infectious Diseases, v. 17, p. 957–964, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25499
dc.identifier.issn.pt_BR.fl_str_mv 1473-3099
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/S1473-3099(17)30366-3
identifier_str_mv PAIXÃO, Enny Santos da et al. Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study. Lancet Infectious Diseases, v. 17, p. 957–964, 2017.
1473-3099
10.1016/S1473-3099(17)30366-3
url https://www.arca.fiocruz.br/handle/icict/25499
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