Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57162 |
Resumo: | Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA. |
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Haslwanter, DeniseLasso, GorkaVec, Anna Z.Furtado, Nathália DiasRaphael, Lidiane Menezes SouzaTse, Alexandra L.Sun, YanStransky, StephaniePedreño-Lopez, NúriaCorreia, Carolina ArgondizoBornholdt, Zachary A.Sakharkar, MrunalAvelino-Silva, Vivian I.Moyer, Crystal L.Watkins, David I.Kallas, Esper G.Sidoli, SimoneWalker, Laura M.Bonaldo, Myrna C.Chandran, Kartik2023-03-01T12:48:24Z2023-03-01T12:48:24Z2022HASLWANTER, Denise et al. Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell Host & Microbe. v. 30, p. 248-259, Feb. 2022.1934-6069https://www.arca.fiocruz.br/handle/icict/5716210.1016/j.chom.2021.12.009engCell PressCaracterísticas específicas do genótipoReduzem a suscetibilidade do amarelo sul-americanoAnticorpos induzidos por vacinaCepas de vírus da febre AmarelaYellow fever virusGenotype-specific features reduceSusceptibility of South AmericanYellow fever virus strainsVaccine-induced antibodiesGenotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.Adimab, LLC, Lebanon, NH 03766, USA / Present address: Dyno Therapeutics, Cambridge, MA 02139, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA.Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Pathology, The George Washington University, Washington, DC 20037, USA / Present address: IrsiCaixa AIDS Research Institute, 08916 Badalona, Spain.Universidade de São Paulo. Faculdade de Medicina. Laboratório de Imunologia Clínica e Alergia. São Paulo, SP, Brasil.Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.Adimab, LLC, Lebanon, NH 03766, USA.Universidade de São Paulo. Faculdade de Medicina. Departamento de Molé stias Infecciosas e Parasitárias. São Paulo, SP, Brasil.Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.Department of Pathology, The George Washington University, Washington, DC 20037, USA.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil.Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Adimab, LLC, Lebanon, NH 03766, USA / Adagio Therapeutics Inc., Waltham, MA 02451, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA / Lead contact.The resurgence of yellow fever in SouthAmerica has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccineinduced antibodies is unknown. We show that antiviral potency of the polyclonal antibody response in vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to amino acid changes at two sites in central domain II of the glycoprotein E, including multiple changes at the domain I–domain II hinge, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for updating vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57162/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMirnaBonaldo_LidianeRafael_etal-IOC_2021.pdfMirnaBonaldo_LidianeRafael_etal-IOC_2021.pdfapplication/pdf5146510https://www.arca.fiocruz.br/bitstream/icict/57162/2/MirnaBonaldo_LidianeRafael_etal-IOC_2021.pdf720937ec7fc65226d9f86f908b48f3c6MD52icict/571622023-09-04 11:30:02.658oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:30:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| title |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| spellingShingle |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies Haslwanter, Denise Características específicas do genótipo Reduzem a suscetibilidade do amarelo sul-americano Anticorpos induzidos por vacina Cepas de vírus da febre Amarela Yellow fever virus Genotype-specific features reduce Susceptibility of South American Yellow fever virus strains Vaccine-induced antibodies |
| title_short |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| title_full |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| title_fullStr |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| title_full_unstemmed |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| title_sort |
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies |
| author |
Haslwanter, Denise |
| author_facet |
Haslwanter, Denise Lasso, Gorka Vec, Anna Z. Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Tse, Alexandra L. Sun, Yan Stransky, Stephanie Pedreño-Lopez, Núria Correia, Carolina Argondizo Bornholdt, Zachary A. Sakharkar, Mrunal Avelino-Silva, Vivian I. Moyer, Crystal L. Watkins, David I. Kallas, Esper G. Sidoli, Simone Walker, Laura M. Bonaldo, Myrna C. Chandran, Kartik |
| author_role |
author |
| author2 |
Lasso, Gorka Vec, Anna Z. Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Tse, Alexandra L. Sun, Yan Stransky, Stephanie Pedreño-Lopez, Núria Correia, Carolina Argondizo Bornholdt, Zachary A. Sakharkar, Mrunal Avelino-Silva, Vivian I. Moyer, Crystal L. Watkins, David I. Kallas, Esper G. Sidoli, Simone Walker, Laura M. Bonaldo, Myrna C. Chandran, Kartik |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Haslwanter, Denise Lasso, Gorka Vec, Anna Z. Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Tse, Alexandra L. Sun, Yan Stransky, Stephanie Pedreño-Lopez, Núria Correia, Carolina Argondizo Bornholdt, Zachary A. Sakharkar, Mrunal Avelino-Silva, Vivian I. Moyer, Crystal L. Watkins, David I. Kallas, Esper G. Sidoli, Simone Walker, Laura M. Bonaldo, Myrna C. Chandran, Kartik |
| dc.subject.other.en_US.fl_str_mv |
Características específicas do genótipo Reduzem a suscetibilidade do amarelo sul-americano Anticorpos induzidos por vacina Cepas de vírus da febre Amarela |
| topic |
Características específicas do genótipo Reduzem a suscetibilidade do amarelo sul-americano Anticorpos induzidos por vacina Cepas de vírus da febre Amarela Yellow fever virus Genotype-specific features reduce Susceptibility of South American Yellow fever virus strains Vaccine-induced antibodies |
| dc.subject.en.en_US.fl_str_mv |
Yellow fever virus Genotype-specific features reduce Susceptibility of South American Yellow fever virus strains Vaccine-induced antibodies |
| description |
Department of Microbiology and Immunology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA. |
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2022 |
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2022 |
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2023-03-01T12:48:24Z |
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2023-03-01T12:48:24Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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HASLWANTER, Denise et al. Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell Host & Microbe. v. 30, p. 248-259, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/57162 |
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1934-6069 |
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10.1016/j.chom.2021.12.009 |
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HASLWANTER, Denise et al. Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell Host & Microbe. v. 30, p. 248-259, Feb. 2022. 1934-6069 10.1016/j.chom.2021.12.009 |
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Cell Press |
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Cell Press |
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