Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28994 |
Resumo: | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. |
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Diniz, Michely C.Costa, Marcília P.Pacheco, Ana C. L.Kamimura, Michel T.Silva, Samara C.Carneiro, Laura D. G.Sousa, Ana P. L.Soares, Carlos E. A.Souza, Celeste S. F.2018-09-23T13:31:13Z2018-09-23T13:31:13Z2009DINIZ, Michely C. et al. Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation. Genetics and Molecular Biology, v.32, n.3, p.652-665, 2009.1415-4757https://www.arca.fiocruz.br/handle/icict/289941678-4685engSociedade Brasileira de GenéticaLeishmaniaFagossomosproteínas flagelaresproteínas que interagem com actinaactin-interacting proteins (AIPs)flagellar proteinsLeishmaniacoronin and Arp2/3phagosomeActin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Severalmotileprocessesareresponsibleforthemovementofproteinsintoandwithintheflagellarmembrane,butlittle is known about the process by which specific proteins (either actin-associated or not) are targeted to protozoan flagellar membranes. Actin is a major cytoskeleton protein, while polymerization and depolymerization of parasite actin and actin-interacting proteins (AIPs) during both processes of motility and host cell entry might be key events for successful infection. For a better understanding the eukaryotic flagellar dynamics, we have surveyed genomes, transcriptomes and proteomes of pathogenic L eis h m a nia s p p . to identify pertinent genes/proteins and to build in silico models to properly address their putative roles in trypanosomatid virulence. In a search for AIPs involved in flagellar activities, we applied computational biology and proteomic tools to infer from the biological meaning of coroninsandArp2/3,twoimportantelementsinphagosomeformationafterparasitephagocytosisbymacrophages. Resultspresentedhereprovidethefirstreportof Leishmania coroninandArp2/3asflagellarproteinsthatalsomight be involved in phagosome formation through actin polymerization within the flagellar environment. This is an issue worthy of further in vit r o examination that remains now as a direct, positive bioinformatics-derived inference to be presented.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28994/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcelestef_souza_etal_IOC_2009.pdfcelestef_souza_etal_IOC_2009.pdfapplication/pdf3801077https://www.arca.fiocruz.br/bitstream/icict/28994/2/celestef_souza_etal_IOC_2009.pdfc9764f8ad51947bff77507ad61ea00aeMD52TEXTcelestef_souza_etal_IOC_2009.pdf.txtcelestef_souza_etal_IOC_2009.pdf.txtExtracted texttext/plain63508https://www.arca.fiocruz.br/bitstream/icict/28994/3/celestef_souza_etal_IOC_2009.pdf.txt5f1042af70e41cd59b6c4b04223a8c95MD53icict/289942018-09-24 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| dc.title.pt_BR.fl_str_mv |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| title |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| spellingShingle |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation Diniz, Michely C. Leishmania Fagossomos proteínas flagelares proteínas que interagem com actina actin-interacting proteins (AIPs) flagellar proteins Leishmania coronin and Arp2/3 phagosome |
| title_short |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| title_full |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| title_fullStr |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| title_full_unstemmed |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| title_sort |
Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation |
| author |
Diniz, Michely C. |
| author_facet |
Diniz, Michely C. Costa, Marcília P. Pacheco, Ana C. L. Kamimura, Michel T. Silva, Samara C. Carneiro, Laura D. G. Sousa, Ana P. L. Soares, Carlos E. A. Souza, Celeste S. F. |
| author_role |
author |
| author2 |
Costa, Marcília P. Pacheco, Ana C. L. Kamimura, Michel T. Silva, Samara C. Carneiro, Laura D. G. Sousa, Ana P. L. Soares, Carlos E. A. Souza, Celeste S. F. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Diniz, Michely C. Costa, Marcília P. Pacheco, Ana C. L. Kamimura, Michel T. Silva, Samara C. Carneiro, Laura D. G. Sousa, Ana P. L. Soares, Carlos E. A. Souza, Celeste S. F. |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania Fagossomos proteínas flagelares proteínas que interagem com actina |
| topic |
Leishmania Fagossomos proteínas flagelares proteínas que interagem com actina actin-interacting proteins (AIPs) flagellar proteins Leishmania coronin and Arp2/3 phagosome |
| dc.subject.en.pt_BR.fl_str_mv |
actin-interacting proteins (AIPs) flagellar proteins Leishmania coronin and Arp2/3 phagosome |
| description |
Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2018-09-23T13:31:13Z |
| dc.date.available.fl_str_mv |
2018-09-23T13:31:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
DINIZ, Michely C. et al. Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation. Genetics and Molecular Biology, v.32, n.3, p.652-665, 2009. |
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https://www.arca.fiocruz.br/handle/icict/28994 |
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1415-4757 |
| dc.identifier.eissn.none.fl_str_mv |
1678-4685 |
| identifier_str_mv |
DINIZ, Michely C. et al. Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation. Genetics and Molecular Biology, v.32, n.3, p.652-665, 2009. 1415-4757 1678-4685 |
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Sociedade Brasileira de Genética |
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Sociedade Brasileira de Genética |
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