In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi

Detalhes bibliográficos
Autor(a) principal: Silva, Cristiane França da
Data de Publicação: 2014
Outros Autores: Batista, Denise da Gama Jaen, Batista, Marcos Meuser, Lionel, Jessica, Hammer, Erica Ripoll, Brun, Reto, Soeiro, Maria de Nazaré Correia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10057
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
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spelling Silva, Cristiane França daBatista, Denise da Gama JaenBatista, Marcos MeuserLionel, JessicaHammer, Erica RipollBrun, RetoSoeiro, Maria de Nazaré Correia2015-04-17T17:04:29Z2015-04-17T17:04:29Z2014SILVA, Cristiane França da et al. In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, n.141, p. 367-373, 2014.0031-1820https://www.arca.fiocruz.br/handle/icict/1005710.1017/S0031182013001601engCambridge University PressDoença de ChagasTripanosoma CruziQuimioterapiaInfecções por ProtozoáriosChagas DiseaseTripanosoma CruziChloroaryl-substituted imidazoleViniconazoleChemotherapyIn vitroIn vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilSwiss Tropical and Public Health Institute.Department of Medical Parasitology and Infection Biology. Basel, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, BrasilChagas disease (CD) is caused by the intracellular protozoan parasite Trypanosoma cruzi and affects more than 10 million people in poor areas of Latin America. There is an urgent need for alternative drugs with better safety, broader efficacy, lower costs and shorter time of administration. Thus the biological activity of viniconazole, a chloroaryl-substituted imidazole was investigated using in vitro and in vivo screening models of T. cruzi infection. Ultrastructural findings demonstrated that the most frequent cellular damage was associated with plasma membrane (blebs and shedding events), Golgi (swelling aspects) and the appearance of large numbers of vacuoles suggesting an autophagic process. Our data demonstrated that although this compound is effective against bloodstream and intracellular forms (16 and 24 μM, respectively) in vitro, it does not present in vivo efficacy. Due to the urgent need for novel agents against T. cruzi, the screening of natural and synthetic products must be further supported with the aim of finding more selective and affordable drugs for CD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10057/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALcristiane_françasilvaetal_IOC_2014.pdfapplication/pdf618015https://www.arca.fiocruz.br/bitstream/icict/10057/2/cristiane_fran%c3%a7asilvaetal_IOC_2014.pdf5bd4ffa2626723ec949315e3ffda3a57MD52TEXTcristiane_françasilvaetal_IOC_2014.pdf.txtcristiane_françasilvaetal_IOC_2014.pdf.txtExtracted texttext/plain28146https://www.arca.fiocruz.br/bitstream/icict/10057/3/cristiane_fran%c3%a7asilvaetal_IOC_2014.pdf.txt20bc0cb13c6991e530892b9a7637e402MD53icict/100572022-06-24 13:10:55.996oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
title In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
spellingShingle In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
Silva, Cristiane França da
Doença de Chagas
Tripanosoma Cruzi
Quimioterapia
Infecções por Protozoários
Chagas Disease
Tripanosoma Cruzi
Chloroaryl-substituted imidazole
Viniconazole
Chemotherapy
In vitro
title_short In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
title_full In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
title_fullStr In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
title_full_unstemmed In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
title_sort In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
author Silva, Cristiane França da
author_facet Silva, Cristiane França da
Batista, Denise da Gama Jaen
Batista, Marcos Meuser
Lionel, Jessica
Hammer, Erica Ripoll
Brun, Reto
Soeiro, Maria de Nazaré Correia
author_role author
author2 Batista, Denise da Gama Jaen
Batista, Marcos Meuser
Lionel, Jessica
Hammer, Erica Ripoll
Brun, Reto
Soeiro, Maria de Nazaré Correia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Cristiane França da
Batista, Denise da Gama Jaen
Batista, Marcos Meuser
Lionel, Jessica
Hammer, Erica Ripoll
Brun, Reto
Soeiro, Maria de Nazaré Correia
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Tripanosoma Cruzi
Quimioterapia
Infecções por Protozoários
topic Doença de Chagas
Tripanosoma Cruzi
Quimioterapia
Infecções por Protozoários
Chagas Disease
Tripanosoma Cruzi
Chloroaryl-substituted imidazole
Viniconazole
Chemotherapy
In vitro
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Tripanosoma Cruzi
Chloroaryl-substituted imidazole
Viniconazole
Chemotherapy
In vitro
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-17T17:04:29Z
dc.date.available.fl_str_mv 2015-04-17T17:04:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Cristiane França da et al. In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, n.141, p. 367-373, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10057
dc.identifier.issn.pt_BR.fl_str_mv 0031-1820
dc.identifier.doi.pt_BR.fl_str_mv 10.1017/S0031182013001601
identifier_str_mv SILVA, Cristiane França da et al. In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, n.141, p. 367-373, 2014.
0031-1820
10.1017/S0031182013001601
url https://www.arca.fiocruz.br/handle/icict/10057
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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