Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.neurobiolaging.2022.02.010 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/54574 |
Resumo: | Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Júlia T.Dakic, VanjaVitória, GabrielaPedrosa, Carolina da S.G.Mendes, MayaraAragão, Luiz Guilherme H.S.Cardim-Pires, Thyago R.Lelièvre, DamienFurtado, Daniel RodriguesPinheiro, Roberta O.Foguel, DéboraBreton, LionelBouez, CharbelDe Vecchi, RodrigoGuimarães, Marília Zaluar P.Rehen, Stevens2022-08-10T19:59:54Z2022-08-10T19:59:54Z2022OLIVEIRA, Jùlia T. et al. Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis. Neurology of Aging, v. 113, p. 108-117, Feb. 2022.0197-4580https://www.arca.fiocruz.br/handle/icict/5457410.1016/j.neurobiolaging.2022.02.010engElsevierEpidermeDegeneração da peleInflamatórioNeurodegeneraçãoα-SinucleínaEpidermisSkin degenerationInflammagingNeurodegenerationα-SynucleinOligomeric α-Synuclein induces skin degeneration in reconstructed human epidermisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Pesquisa e Inovação da L'Oréal. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.EPISKIN SA., Lyon, France.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.L’Oréal Research & Innovation, Aulnay-sous-boi. France.L’Oréal Research & Innovation. Clark, NJ, USA.Pesquisa e Inovação da L'Oréal. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil..Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degenera- tion. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration. However, little is known about their putative role in skin physiology and sensitivity. To unravel this possible role, we inves- tigated the impact of oligomeric α-Synuclein (O α-Syn) in 2D and 3D keratinocyte human models. Exoge- nous O α-Syn caused degeneration of reconstructed human epidermis (RHE) by diminishing proliferation and thickness of the stratum basale. O α-Syn also increased NF-kB nuclear translocation in keratinocytes and triggered inflammation in the RHE, by increasing expression of interleukin-1 βand tumor necrosis factor-alpha, and the release of tumor necrosis factor-alpha in a time-dependent manner. Dexamethasone and an IL-1 βinhibitor partially diminished RHE degeneration caused by O α-Syn. These findings sug- gest that O α-Syn induces epidermal inflammation and decreases keratinocyte proliferation, and therefore might contribute to epidermal degeneration observed in human skin aging.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54574/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRobertaPinheiro_JuliaOliveira_etal_IOC_2022.pdfRobertaPinheiro_JuliaOliveira_etal_IOC_2022.pdfapplication/pdf2755481https://www.arca.fiocruz.br/bitstream/icict/54574/2/RobertaPinheiro_JuliaOliveira_etal_IOC_2022.pdf560478ea9b2771006126aefcef1cf561MD52icict/545742022-08-10 16:59:54.802oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-10T19:59:54Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.pt_BR.fl_str_mv |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| title |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| spellingShingle |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis Oliveira, Júlia T. Epiderme Degeneração da pele Inflamatório Neurodegeneração α-Sinucleína Epidermis Skin degeneration Inflammaging Neurodegeneration α-Synuclein |
| title_short |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| title_full |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| title_fullStr |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| title_full_unstemmed |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| title_sort |
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis |
| author |
Oliveira, Júlia T. |
| author_facet |
Oliveira, Júlia T. Dakic, Vanja Vitória, Gabriela Pedrosa, Carolina da S.G. Mendes, Mayara Aragão, Luiz Guilherme H.S. Cardim-Pires, Thyago R. Lelièvre, Damien Furtado, Daniel Rodrigues Pinheiro, Roberta O. Foguel, Débora Breton, Lionel Bouez, Charbel De Vecchi, Rodrigo Guimarães, Marília Zaluar P. Rehen, Stevens |
| author_role |
author |
| author2 |
Dakic, Vanja Vitória, Gabriela Pedrosa, Carolina da S.G. Mendes, Mayara Aragão, Luiz Guilherme H.S. Cardim-Pires, Thyago R. Lelièvre, Damien Furtado, Daniel Rodrigues Pinheiro, Roberta O. Foguel, Débora Breton, Lionel Bouez, Charbel De Vecchi, Rodrigo Guimarães, Marília Zaluar P. Rehen, Stevens |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Júlia T. Dakic, Vanja Vitória, Gabriela Pedrosa, Carolina da S.G. Mendes, Mayara Aragão, Luiz Guilherme H.S. Cardim-Pires, Thyago R. Lelièvre, Damien Furtado, Daniel Rodrigues Pinheiro, Roberta O. Foguel, Débora Breton, Lionel Bouez, Charbel De Vecchi, Rodrigo Guimarães, Marília Zaluar P. Rehen, Stevens |
| dc.subject.other.pt_BR.fl_str_mv |
Epiderme Degeneração da pele Inflamatório Neurodegeneração α-Sinucleína |
| topic |
Epiderme Degeneração da pele Inflamatório Neurodegeneração α-Sinucleína Epidermis Skin degeneration Inflammaging Neurodegeneration α-Synuclein |
| dc.subject.en.pt_BR.fl_str_mv |
Epidermis Skin degeneration Inflammaging Neurodegeneration α-Synuclein |
| description |
Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-08-10T19:59:54Z |
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2022-08-10T19:59:54Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, Jùlia T. et al. Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis. Neurology of Aging, v. 113, p. 108-117, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/54574 |
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0197-4580 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.neurobiolaging.2022.02.010 |
| identifier_str_mv |
OLIVEIRA, Jùlia T. et al. Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis. Neurology of Aging, v. 113, p. 108-117, Feb. 2022. 0197-4580 10.1016/j.neurobiolaging.2022.02.010 |
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https://www.arca.fiocruz.br/handle/icict/54574 |
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Elsevier |
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Elsevier |
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