Density of mast cells and microvessels in minor salivary gland tumors

Detalhes bibliográficos
Autor(a) principal: Vidal, Manuela Torres Andion
Data de Publicação: 2013
Outros Autores: Araújo, Iguaracyra Barreto de Oliveira, Gurgel, Clarissa Araújo Silva, Pereira, Francisco de Assis Caldas, Vilas Boas, Deise Souza, Ramos, Eduardo Antônio Gonçalves, Agra, Ivan Marcelo Gonçalves, Barros, Adna Conceição, Freitas, Valéria Souza, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8910
Resumo: Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
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spelling Vidal, Manuela Torres AndionAraújo, Iguaracyra Barreto de OliveiraGurgel, Clarissa Araújo SilvaPereira, Francisco de Assis CaldasVilas Boas, Deise SouzaRamos, Eduardo Antônio GonçalvesAgra, Ivan Marcelo GonçalvesBarros, Adna ConceiçãoFreitas, Valéria SouzaSantos, Jean Nunes dos2014-11-19T12:59:39Z2014-11-19T12:59:39Z2013VIDAL. M. T. A. et al. Density of mast cells and microvessels in minor salivary gland tumors. Tumour Biology, v. 34, n. 1, p. 309-316, 2013.1423-0380https://www.arca.fiocruz.br/handle/icict/891010.1007/s13277-012-0552-7engSpringerDensity of mast cells and microvessels in minor salivary gland tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.Aristides Maltez Hospital. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Salvador, BA, Brasil.Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.Federal University of Bahia. Department of Bio-morphology. Institute of Health Sciences. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Aristides Maltez Hospital. Department of Head and Neck Surgery. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.State University of Feira de Santana. Department of Health (Oral Pathology). Feira de Santana, BA, Brasil.Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.The aim of this study was to investigate the density of mast cells and microvessels in minor salivary gland tumors. Forty-one cases of minor salivary gland tumors (pleomorphic adenoma, n = 10; adenoid cystic carcinoma, n = 11; mucoepidermoid carcinoma, n = 10; and polymorphous low-grade adenocarcinoma) were investigated using immunohistochemistry for mast cell tryptase and von-Willebrand factor. Density of mast cells was higher in mucoepidermoid carcinoma; however, no differences in the number of these cells were observed between the different types of tumors (p > 0.05). The number of mast cells was higher in periparenchymal areas in all tumors, but the difference was not significant (p > 0.05). Mucoepidermoid carcinoma showed the largest number of periparenchymal mast cells, whereas pleomorphic adenomas showed the smallest number of intraparenchymal mast cells (p > 0.05). The highest microvessel density was observed in mucoepidermoid carcinomas, being this difference statistically significant when mucoepidermoid carcinoma was compared to pleomorphic adenoma (p = 0.0034) and polymorphous low-grade adenocarcinoma (p = 0.004). Microvessel density was significantly higher in adenoid cystic carcinoma when compared to pleomorphic adenoma (p = 0.0406) and polymorphous low-grade adenocarcinoma (p = 0.0123). Comparison of mast cells and microvessel densities showed no significant difference between tumors. A quantitative difference in mast cells and microvessels was observed, particularly in mucoepidermoid carcinoma, a finding supporting the aggressive behavior of malignant salivary gland tumors without myoepithelial differentiation. Further studies are needed to determine the role of mast cells in angiogenesis, as well as in the development and biological behavior of these tumors.Salivary gland tumorsMast cellMicrovesselsMastócitosMicrovasos/patologiaNeoplasias das Glândulas Salivares/irrigação sanguíneaNeoplasias das Glândulas Salivares/patologiaGlândulas Salivares MenoresAdenocarcinoma/irrigação sanguíneaAdenocarcinoma/patologiaAdenoma Pleomorfo/irrigação sanguíneaAdenoma Pleomorfo/patologiaCarcinoma Adenoide Cístico/irrigação sanguíneaCarcinoma Adenoide Cístico/patologiaCarcinoma Mucoepidermoide/irrigação sanguíneaHumanosTriptases/análiseMarcadores Biológicos de TumorFator de von Willebrand/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVidal MTA Density of....pdfVidal MTA Density of....pdfapplication/pdf658780https://www.arca.fiocruz.br/bitstream/icict/8910/2/Vidal%20MTA%20Density%20of....pdf07d7298c777d3158f9f2a2ca8d44eab9MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8910/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTVidal MTA Density of....pdf.txtVidal MTA Density of....pdf.txtExtracted texttext/plain35267https://www.arca.fiocruz.br/bitstream/icict/8910/4/Vidal%20MTA%20Density%20of....pdf.txt99cf4702ff8f0ee227236e4a2a17a913MD54icict/89102023-03-15 14:32:59.346oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Density of mast cells and microvessels in minor salivary gland tumors
title Density of mast cells and microvessels in minor salivary gland tumors
spellingShingle Density of mast cells and microvessels in minor salivary gland tumors
Vidal, Manuela Torres Andion
Salivary gland tumors
Mast cell
Microvessels
Mastócitos
Microvasos/patologia
Neoplasias das Glândulas Salivares/irrigação sanguínea
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores
Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/patologia
Adenoma Pleomorfo/irrigação sanguínea
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/irrigação sanguínea
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/irrigação sanguínea
Humanos
Triptases/análise
Marcadores Biológicos de Tumor
Fator de von Willebrand/análise
title_short Density of mast cells and microvessels in minor salivary gland tumors
title_full Density of mast cells and microvessels in minor salivary gland tumors
title_fullStr Density of mast cells and microvessels in minor salivary gland tumors
title_full_unstemmed Density of mast cells and microvessels in minor salivary gland tumors
title_sort Density of mast cells and microvessels in minor salivary gland tumors
author Vidal, Manuela Torres Andion
author_facet Vidal, Manuela Torres Andion
Araújo, Iguaracyra Barreto de Oliveira
Gurgel, Clarissa Araújo Silva
Pereira, Francisco de Assis Caldas
Vilas Boas, Deise Souza
Ramos, Eduardo Antônio Gonçalves
Agra, Ivan Marcelo Gonçalves
Barros, Adna Conceição
Freitas, Valéria Souza
Santos, Jean Nunes dos
author_role author
author2 Araújo, Iguaracyra Barreto de Oliveira
Gurgel, Clarissa Araújo Silva
Pereira, Francisco de Assis Caldas
Vilas Boas, Deise Souza
Ramos, Eduardo Antônio Gonçalves
Agra, Ivan Marcelo Gonçalves
Barros, Adna Conceição
Freitas, Valéria Souza
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vidal, Manuela Torres Andion
Araújo, Iguaracyra Barreto de Oliveira
Gurgel, Clarissa Araújo Silva
Pereira, Francisco de Assis Caldas
Vilas Boas, Deise Souza
Ramos, Eduardo Antônio Gonçalves
Agra, Ivan Marcelo Gonçalves
Barros, Adna Conceição
Freitas, Valéria Souza
Santos, Jean Nunes dos
dc.subject.en.pt_BR.fl_str_mv Salivary gland tumors
Mast cell
Microvessels
topic Salivary gland tumors
Mast cell
Microvessels
Mastócitos
Microvasos/patologia
Neoplasias das Glândulas Salivares/irrigação sanguínea
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores
Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/patologia
Adenoma Pleomorfo/irrigação sanguínea
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/irrigação sanguínea
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/irrigação sanguínea
Humanos
Triptases/análise
Marcadores Biológicos de Tumor
Fator de von Willebrand/análise
dc.subject.decs.pt_BR.fl_str_mv Mastócitos
Microvasos/patologia
Neoplasias das Glândulas Salivares/irrigação sanguínea
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores
Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/patologia
Adenoma Pleomorfo/irrigação sanguínea
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/irrigação sanguínea
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/irrigação sanguínea
Humanos
Triptases/análise
Marcadores Biológicos de Tumor
Fator de von Willebrand/análise
description Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-11-19T12:59:39Z
dc.date.available.fl_str_mv 2014-11-19T12:59:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIDAL. M. T. A. et al. Density of mast cells and microvessels in minor salivary gland tumors. Tumour Biology, v. 34, n. 1, p. 309-316, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8910
dc.identifier.issn.none.fl_str_mv 1423-0380
dc.identifier.doi.none.fl_str_mv 10.1007/s13277-012-0552-7
identifier_str_mv VIDAL. M. T. A. et al. Density of mast cells and microvessels in minor salivary gland tumors. Tumour Biology, v. 34, n. 1, p. 309-316, 2013.
1423-0380
10.1007/s13277-012-0552-7
url https://www.arca.fiocruz.br/handle/icict/8910
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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