IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15197 |
Resumo: | Aix-Marseille Universit e. Marseille, France / Inserm. Marseille, France |
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Sertorio, MathieuHou, XunyaCarmo, Rodrigo FDessein, HéliaCabantous, SandrineAbdelwahed, MohammedRomano, AudreyAlbuquerque, FernandaVasconcelos, LuydsonCarmo, Theomira Mauadie de AzevedoLi, JunVaroquaux, ArthurArnaud, ViolaineOliveira, PabloHamdoun, AnasHe, HongbinAdbelmaboud, SuzanMergani, AdilZhou, JieMonis, AhmedPereira, Leila BeltraoHalfon, PhilippeBourlière, MarcParana, RaymundoReis, Mitermayer Galvão dosGonnelli, DavidMoura, PatriciaElwali, Nasr EldinArgiro, LaurentLi, YueshengDessein, Alain2016-08-05T13:27:26Z2016-08-05T13:27:26Z2015SERTORIO, M. et al. IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology, v. 61, p. 1321-1331, 2015.0270-9139https://www.arca.fiocruz.br/handle/icict/1519710.1002/hep.27629engWileyIL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAix-Marseille Universit e. Marseille, France / Inserm. Marseille, FranceHunan Institute of Parasitic Diseases. Hua-Ban Qiao Road Yueyang. ChinaUniversidade Federal do Vale do São Francisco. Petrolina, BrasilAix-Marseille Universit e. Marseille, France / Inserm. Marseille, FranceAix-Marseille Universit e. Marseille, France / Inserm. Marseille, FranceInstitute of Nuclear Medicine. Wad Medani, SudanAix-Marseille Universit e. Marseille, France / Inserm. Marseille, FranceFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstituto do Figado. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHunan Institute of Parasitic Diseases. Hua-Ban Qiao Road Yueyang. ChinaAPHM. CHU Timone, Radiology. Marseille, FranceAix-Marseille Universit e. Marseille, France / Inserm. Marseille, FranceAix-Marseille Universit e. Marseille, France / Inserm. Marseille, France / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstitute of Nuclear Medicine. Wad Medani, SudanHunan Institute of Parasitic Diseases. Hua-Ban Qiao Road Yueyang. ChinaInstitute of Nuclear Medicine. Wad Medani, SudanTaif University. College of Applied Medical Sciences. Turabah, Saudi ArabiaInstitute of Nuclear Medicine. Wad Medani, SudanInstitute of Nuclear Medicine. Wad Medani, SudanInstituto do Figado. Recife, PE, BrasilHôpital Europeen. Virology Department. Marseille, FranceHôpital Saint-Joseph. Hepatology Department. Marseille, FranceFederal University of Bahia. Faculty of Medicine. Department of Medicine.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAPHM. La Conception, Chirurgie plastique et reconstructrice. Marseille, FranceUniversidade Pernambuco. Instituto de Ciencias Biologicas. Recife, PE, BrasilInstitute of Nuclear Medicine. Wad Medani, SudanAix-Marseille Universite. Marseille, France / Inserm. Marseille, FranceHunan Institute of Parasitic Diseases. Hua-Ban Qiao Road Yueyang. ChinaAix-Marseille Universite. Marseille, France / Inserm. Marseille, France / APHM. CHU Timone. Marseille, FranceInterleukin (IL)-22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL-22 may also cause inflammation and abnormal cell proliferation. The binding of IL-22 to its receptor is competed by IL-22 binding protein (IL-22BP), which may limit the deleterious effects of IL-22. The role of IL-22 and IL-22BP in chronic liver diseases is unknown. We addressed this question in individuals chronically infected with schistosomes or hepatitis C virus (HCV). We first demonstrate that schistosome eggs stimulate production of IL-22 transcripts and inhibit accumulation of IL22-BP transcripts in schistosome-infected mice, and that schistosome eggs selectively stimulate production of IL-22 in cultures of blood leukocytes from individuals chronically infected with Schistosoma japonicum. High IL-22 levels in cultures correlated with protection against hepatic fibrosis and portal hypertension. To test further the implication of IL-22/IL-22BP in hepatic disease, we analyzed common genetic variants of IL22RA2, which encodes IL-22BP, and found that the genotypes, AA, GG of rs6570136 (P = 0.003; odds ratio [OR] = 2), and CC, TT of rs2064501 (P = 0.01; OR = 2), were associated with severe fibrosis in Chinese infected with S. japonicum. We confirmed this result in Sudanese (rs6570136 GG [P = 0.0007; OR = 8.2], rs2064501 TT [P = 0.02; OR = 3.1]), and Brazilians (rs6570136 GG [P = 0.003; OR = 26], rs2064501 TC, TT (P = 0.03; OR = 11]) infected with S. mansoni. The aggravating genotypes were associated with high IL22RA2 transcripts levels. Furthermore, these same variants were also associated with HCV-induced fibrosis and cirrhosis (rs6570136 GG, GA [P = 0.007; OR = 1.7], rs2064501 TT, TC (P = 0.004; OR = 2.4]). Conclusions: These results provide strong evidence that IL-22 protects against and IL-22BP aggravates liver fibrosis and cirrhosis in humans with chronic liver infections. Thus, pharmacological modulation of IL-22 BP may be an effective strategy to limit cirrhosis.Hepatitis CInterleukinsLiver cirrhosisAdultHumansSchistosomiasisReceptors, interleukininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15197/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSertorio_M Il-22 and IL-22 binding....pdfSertorio_M Il-22 and IL-22 binding....pdfapplication/pdf739258https://www.arca.fiocruz.br/bitstream/icict/15197/2/Sertorio_M%20Il-22%20and%20IL-22%20binding....pdff1a2d1d9b56d5834a1a008d07af30232MD52TEXTSertorio_M Il-22 and IL-22 binding....pdf.txtSertorio_M Il-22 and IL-22 binding....pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| title |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| spellingShingle |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections Sertorio, Mathieu Hepatitis C Interleukins Liver cirrhosis Adult Humans Schistosomiasis Receptors, interleukin |
| title_short |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| title_full |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| title_fullStr |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| title_full_unstemmed |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| title_sort |
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections |
| author |
Sertorio, Mathieu |
| author_facet |
Sertorio, Mathieu Hou, Xunya Carmo, Rodrigo F Dessein, Hélia Cabantous, Sandrine Abdelwahed, Mohammed Romano, Audrey Albuquerque, Fernanda Vasconcelos, Luydson Carmo, Theomira Mauadie de Azevedo Li, Jun Varoquaux, Arthur Arnaud, Violaine Oliveira, Pablo Hamdoun, Anas He, Hongbin Adbelmaboud, Suzan Mergani, Adil Zhou, Jie Monis, Ahmed Pereira, Leila Beltrao Halfon, Philippe Bourlière, Marc Parana, Raymundo Reis, Mitermayer Galvão dos Gonnelli, David Moura, Patricia Elwali, Nasr Eldin Argiro, Laurent Li, Yuesheng Dessein, Alain |
| author_role |
author |
| author2 |
Hou, Xunya Carmo, Rodrigo F Dessein, Hélia Cabantous, Sandrine Abdelwahed, Mohammed Romano, Audrey Albuquerque, Fernanda Vasconcelos, Luydson Carmo, Theomira Mauadie de Azevedo Li, Jun Varoquaux, Arthur Arnaud, Violaine Oliveira, Pablo Hamdoun, Anas He, Hongbin Adbelmaboud, Suzan Mergani, Adil Zhou, Jie Monis, Ahmed Pereira, Leila Beltrao Halfon, Philippe Bourlière, Marc Parana, Raymundo Reis, Mitermayer Galvão dos Gonnelli, David Moura, Patricia Elwali, Nasr Eldin Argiro, Laurent Li, Yuesheng Dessein, Alain |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sertorio, Mathieu Hou, Xunya Carmo, Rodrigo F Dessein, Hélia Cabantous, Sandrine Abdelwahed, Mohammed Romano, Audrey Albuquerque, Fernanda Vasconcelos, Luydson Carmo, Theomira Mauadie de Azevedo Li, Jun Varoquaux, Arthur Arnaud, Violaine Oliveira, Pablo Hamdoun, Anas He, Hongbin Adbelmaboud, Suzan Mergani, Adil Zhou, Jie Monis, Ahmed Pereira, Leila Beltrao Halfon, Philippe Bourlière, Marc Parana, Raymundo Reis, Mitermayer Galvão dos Gonnelli, David Moura, Patricia Elwali, Nasr Eldin Argiro, Laurent Li, Yuesheng Dessein, Alain |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis C Interleukins Liver cirrhosis Adult Humans Schistosomiasis Receptors, interleukin |
| topic |
Hepatitis C Interleukins Liver cirrhosis Adult Humans Schistosomiasis Receptors, interleukin |
| description |
Aix-Marseille Universit e. Marseille, France / Inserm. Marseille, France |
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2015 |
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2015 |
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2016-08-05T13:27:26Z |
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2016-08-05T13:27:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
SERTORIO, M. et al. IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology, v. 61, p. 1321-1331, 2015. |
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https://www.arca.fiocruz.br/handle/icict/15197 |
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0270-9139 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/hep.27629 |
| identifier_str_mv |
SERTORIO, M. et al. IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology, v. 61, p. 1321-1331, 2015. 0270-9139 10.1002/hep.27629 |
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https://www.arca.fiocruz.br/handle/icict/15197 |
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Wiley |
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Wiley |
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