Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005

Detalhes bibliográficos
Autor(a) principal: Braga, Alexandre Sérgio da Costa
Data de Publicação: 2013
Outros Autores: Toledo Junior, Antonio Carlos de Castro, Rabello, Ana Lucia Teles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30536
Resumo: Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brasil.
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spelling Braga, Alexandre Sérgio da CostaToledo Junior, Antonio Carlos de CastroRabello, Ana Lucia Teles2018-12-12T16:47:35Z2018-12-12T16:47:35Z2013BRAGA, Alexandre Sérgio da Costa; TOLEDO JUNIOR, Antonio Carlos de Castro; RABELLO, Ana Lucia Teles. Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005. Rev. Soc. Bras. Med. Trop., v. 46, n. 1, p. 55-59, 2013 .0037-8682https://www.arca.fiocruz.br/handle/icict/3053610.1590/0037-868216432013engSociedade Brasileira de Medicina TropicalLeishmaniose visceralcriançasprognosticoVisceral leishmaniasisChildrenPrognosis.Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brasil.Universidade José do Rosário Vellano. Serviço Multiprofissional de Infectologia.Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil.INTRODUTION: A major concern with the visceral leishmaniasis (VL) is its high lethality rate, even with proper treatment. Low age, prior malnutrition, disease duration prior to diagnosis, severe anemia, fever for more than 60 days, diarrhea and jaundice are known poor prognostic factors. The goals of this study are to describe the clinical and laboratory characteristics of VL among children under 12 years of age and to identify the factors associated with VL poor outcome. METHODS: Two hundred and fifty children under 12 years of age with confirmed VL admitted to Hospital João Paulo II (FHEMIG), Belo Horizonte, Brazil, between January 2001 and December 2005 were evaluated retrospectively. The primary outcome was the poor clinical evolution: sepsis, and/or pneumonia, and/or urinary tract infection, and/or of bleeding (expect epistaxis), and/or severe neutropenia (neutrophil < 500 cells/mm3). Odds ratio (crude and adjusted) and its 95% confidence interval for each variable were calculated. Values less than 0.05 were considered significant. RESULTS: Average age was 3.3 years (3.6 months-11.6 years), 71.2% were younger than 5 years and 47.2% lived in Metropolitan Area of Belo Horizonte. The mean fatality rate was 3.6%. Sixty-six (26.4%) patients presented poor evolution. After a multivariate analysis, age <18 months, abnormal respiratory physical examination on hospital admission, and platelets <85,000/mm3 remained associated with increased chance of poor evolution. CONCLUSIONS: The results suggest that patients aged between 12 and 18 months, with platelet counts bellow 85,000/mm3, and respiratory abnormalities at admission should be considered potentially severe.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30536/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALFactors of poor prognosis of visceral .pdfFactors of poor prognosis of visceral .pdfapplication/pdf4609493https://www.arca.fiocruz.br/bitstream/icict/30536/2/Factors%20of%20poor%20prognosis%20of%20visceral%20.pdf563bf2e0b5ead21661ead07f17390dceMD52TEXTFactors of poor prognosis of visceral .pdf.txtFactors of poor prognosis of visceral .pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
title Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
spellingShingle Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
Braga, Alexandre Sérgio da Costa
Leishmaniose visceral
crianças
prognostico
Visceral leishmaniasis
Children
Prognosis.
title_short Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
title_full Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
title_fullStr Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
title_full_unstemmed Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
title_sort Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005
author Braga, Alexandre Sérgio da Costa
author_facet Braga, Alexandre Sérgio da Costa
Toledo Junior, Antonio Carlos de Castro
Rabello, Ana Lucia Teles
author_role author
author2 Toledo Junior, Antonio Carlos de Castro
Rabello, Ana Lucia Teles
author2_role author
author
dc.contributor.author.fl_str_mv Braga, Alexandre Sérgio da Costa
Toledo Junior, Antonio Carlos de Castro
Rabello, Ana Lucia Teles
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral
crianças
prognostico
topic Leishmaniose visceral
crianças
prognostico
Visceral leishmaniasis
Children
Prognosis.
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Children
Prognosis.
description Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-12-12T16:47:35Z
dc.date.available.fl_str_mv 2018-12-12T16:47:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BRAGA, Alexandre Sérgio da Costa; TOLEDO JUNIOR, Antonio Carlos de Castro; RABELLO, Ana Lucia Teles. Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005. Rev. Soc. Bras. Med. Trop., v. 46, n. 1, p. 55-59, 2013 .
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30536
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-868216432013
identifier_str_mv BRAGA, Alexandre Sérgio da Costa; TOLEDO JUNIOR, Antonio Carlos de Castro; RABELLO, Ana Lucia Teles. Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005. Rev. Soc. Bras. Med. Trop., v. 46, n. 1, p. 55-59, 2013 .
0037-8682
10.1590/0037-868216432013
url https://www.arca.fiocruz.br/handle/icict/30536
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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