Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28918 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil. |
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Raboni, Sonia MaraStella, VanessaCruz, Cristina R.França, João B.Moreira, SuzanaGonçalves, LiliNogueira, Meri B.Vidal, Luine R.Almeida, Sergio M.Debur, Maria C.Carraro, HipolitoSantos, Claudia Nunes Duarte dos2018-09-19T19:09:03Z2018-09-19T19:09:03Z2011RABONI, Sonia M. et al. Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil. Journal of Clinical Microbiology, v. 49, n. 4, p. 1287–1293, 2011.0095-1137https://www.arca.fiocruz.br/handle/icict/2891810.1128/JCM.02205-101098-660XporAmerican Society for MicrobiologyH1N1Influenza A VirusEpidemicsMultiplex Polymerase Chain ReactionMultivariate AnalysisVirus DiseasesSubtipo H1N1 del Virus de la Influenza AReacción en Cadena de la Polimerasa MultiplexAnálisis MultivarianteVirosisVírus da Influenza A Subtipo H1N1EpidemiasReação em Cadeia da Polimerase MultiplexAnálise MultivariadaVirosesLaboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Pediatria. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Serviço de Epidemiologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Serviço de Epidemiologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Secretaria Estadual de Saúde do Paraná. Laboratório de Saúde Pública. Curitiba, PR, Brasil.Universidade Federal do Paraná. Unidade de Terapia Intensiva. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Community respiratory viruses (CRVs) are commonly associated with seasonal infections. They have been associated with higher morbidity and mortality among children, elderly individuals, and immunosuppressed patients. In April 2009, the circulation of a new influenza A virus (FLUA H1N1v) was responsible for the first influenza pandemic of this century. We report the clinical and epidemiological profiles of inpatients infected with CRVs or with FLUA H1N1v at a tertiary care hospital in southern Brazil. In addition, we used these profiles to evaluate survivor and nonsurvivor patients infected with FLUA H1N1v. Multiplex reverse transcription-PCR (RT-PCR) and real time RT-PCR were used to detect viruses in inpatients with respiratory infections. Record data from all patients were reviewed. A total of 171 patients were examined over a period of 16 weeks. Of these, 39% were positive for FLUA H1N1v, 36% were positive for CRVs, and 25% were negative. For the FLUA H1N1v- and CRV-infected patients, epidemiological data regarding median age (30 and 1.5 years), myalgia (44% and 13%), need for mechanical ventilation (44% and 9%), and mortality (35% and 9%) were statistically different. In a multivariate analysis comparing survivor and nonsurvivor patients infected with influenza A virus H1N1, median age and creatine phosphokinase levels were significantly associated with a severe outcome. Seasonal respiratory infections are a continuing concern. Our results highlight the importance of studies on the prevalence and severity of these infections and that investments in programs of clinical and laboratory monitoring are essential to detect the appearance of new infective agents.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/28918/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALJournClinMicr1287.pdfJournClinMicr1287.pdfapplication/pdf369672https://www.arca.fiocruz.br/bitstream/icict/28918/2/JournClinMicr1287.pdf0f535b7c963899b6b0a884fafda065d5MD52TEXTJournClinMicr1287.pdf.txtJournClinMicr1287.pdf.txtExtracted texttext/plain34578https://www.arca.fiocruz.br/bitstream/icict/28918/3/JournClinMicr1287.pdf.txt63047c1042a4cb92c80d3fa1674773e6MD53icict/289182019-11-23 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| dc.title.pt_BR.fl_str_mv |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| title |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| spellingShingle |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil Raboni, Sonia Mara H1N1 Influenza A Virus Epidemics Multiplex Polymerase Chain Reaction Multivariate Analysis Virus Diseases Subtipo H1N1 del Virus de la Influenza A Reacción en Cadena de la Polimerasa Multiplex Análisis Multivariante Virosis Vírus da Influenza A Subtipo H1N1 Epidemias Reação em Cadeia da Polimerase Multiplex Análise Multivariada Viroses |
| title_short |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| title_full |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| title_fullStr |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| title_full_unstemmed |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| title_sort |
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil |
| author |
Raboni, Sonia Mara |
| author_facet |
Raboni, Sonia Mara Stella, Vanessa Cruz, Cristina R. França, João B. Moreira, Suzana Gonçalves, Lili Nogueira, Meri B. Vidal, Luine R. Almeida, Sergio M. Debur, Maria C. Carraro, Hipolito Santos, Claudia Nunes Duarte dos |
| author_role |
author |
| author2 |
Stella, Vanessa Cruz, Cristina R. França, João B. Moreira, Suzana Gonçalves, Lili Nogueira, Meri B. Vidal, Luine R. Almeida, Sergio M. Debur, Maria C. Carraro, Hipolito Santos, Claudia Nunes Duarte dos |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Raboni, Sonia Mara Stella, Vanessa Cruz, Cristina R. França, João B. Moreira, Suzana Gonçalves, Lili Nogueira, Meri B. Vidal, Luine R. Almeida, Sergio M. Debur, Maria C. Carraro, Hipolito Santos, Claudia Nunes Duarte dos |
| dc.subject.other.pt_BR.fl_str_mv |
H1N1 |
| topic |
H1N1 Influenza A Virus Epidemics Multiplex Polymerase Chain Reaction Multivariate Analysis Virus Diseases Subtipo H1N1 del Virus de la Influenza A Reacción en Cadena de la Polimerasa Multiplex Análisis Multivariante Virosis Vírus da Influenza A Subtipo H1N1 Epidemias Reação em Cadeia da Polimerase Multiplex Análise Multivariada Viroses |
| dc.subject.en.pt_BR.fl_str_mv |
Influenza A Virus Epidemics Multiplex Polymerase Chain Reaction Multivariate Analysis Virus Diseases |
| dc.subject.es.pt_BR.fl_str_mv |
Subtipo H1N1 del Virus de la Influenza A Reacción en Cadena de la Polimerasa Multiplex Análisis Multivariante Virosis |
| dc.subject.decs.pt_BR.fl_str_mv |
Vírus da Influenza A Subtipo H1N1 Epidemias Reação em Cadeia da Polimerase Multiplex Análise Multivariada Viroses |
| description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil. |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
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2018-09-19T19:09:03Z |
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2018-09-19T19:09:03Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
RABONI, Sonia M. et al. Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil. Journal of Clinical Microbiology, v. 49, n. 4, p. 1287–1293, 2011. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28918 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0095-1137 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/JCM.02205-10 |
| dc.identifier.eissn.none.fl_str_mv |
1098-660X |
| identifier_str_mv |
RABONI, Sonia M. et al. Laboratory Diagnosis, Epidemiology, and Clinical Outcomes of Pandemic Influenza A and Community Respiratory Viral Infections in Southern Brazil. Journal of Clinical Microbiology, v. 49, n. 4, p. 1287–1293, 2011. 0095-1137 10.1128/JCM.02205-10 1098-660X |
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por |
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American Society for Microbiology |
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American Society for Microbiology |
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