Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection

Detalhes bibliográficos
Autor(a) principal: Lenzi, Henrique Leonel
Data de Publicação: 1996
Outros Autores: Oliveira, Denise N., Lima, Morgana T., Gattass, Cerli Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6002
http://dx.doi.org/10.1006/expr.1996.0086
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
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spelling Lenzi, Henrique LeonelOliveira, Denise N.Lima, Morgana T.Gattass, Cerli Rocha2012-12-14T17:03:20Z2012-12-14T17:03:20Z1996LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996.0014-4894https://www.arca.fiocruz.br/handle/icict/6002http://dx.doi.org/10.1006/expr.1996.0086engAcademic PressTrypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia, Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia, Rio de Janeiro, RJ, BrasilA systematic study of the distribution of intracellular parasites in the organs and tissues of mice acutely infected (15 days) with the CL strain ofTrypanosoma cruziwas performed. Almost all tissues and organs were parasitized with different intensities, including several epithelial cell types. In addition to striated, cardiac, and smooth muscles a very high parasitism of fat cells, pancreas, and genital adnexa was observed. A smaller number of parasites was found in all other structures studied except in highly vascularized structures such as in the penile corpora cavernosa, pulmonary and renal parenchyma, islets of Langerhans, hepatic sinusoids, and in atrial endothelium. This paper also shows, for the first time in the literature, the parasitism of milky spots, cornea epithelium, cornea stroma, retroorbital fibroblasts, seminal vesicles, and coagulative, Cowper's, urethral, preputial, sebaceous anal, and clitoris glands. The results indicated that CL strain is highly invasive, being able to infect cells derived from the three embryonic layers (ectoderm, mesoderm, and endoderm), suggesting that the paninfectivity may influence the outcome of immunological and pathological events.Chagas’ diseaseTrypanosoma cruziProtozoaCL strainInfectivityPathologyEpithelial CellsAdipose tissueH&E, hematoxylin-eosinDoença de ChagasTrypanosoma cruziCélulas EpiteliaisTecido Adiposoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6002/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALTrypanosoma cruzi.pdfTrypanosoma cruzi.pdfapplication/pdf1479916https://www.arca.fiocruz.br/bitstream/icict/6002/2/Trypanosoma%20cruzi.pdf2a892f8476b3e66b591f602919510164MD52TEXTTrypanosoma cruzi.pdf.txtTrypanosoma cruzi.pdf.txtExtracted texttext/plain33804https://www.arca.fiocruz.br/bitstream/icict/6002/5/Trypanosoma%20cruzi.pdf.txt8b6be4261a0d9e17949b263265118bd2MD55THUMBNAILTrypanosoma cruzi.pdf.jpgTrypanosoma cruzi.pdf.jpgGenerated Thumbnailimage/jpeg1852https://www.arca.fiocruz.br/bitstream/icict/6002/4/Trypanosoma%20cruzi.pdf.jpgf1fdfb6be3d04849d982068160fadd59MD54icict/60022018-05-22 15:46:34.469oai:www.arca.fiocruz.br:icict/6002TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-22T18:46:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
title Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
spellingShingle Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
Lenzi, Henrique Leonel
Chagas’ disease
Trypanosoma cruzi
Protozoa
CL strain
Infectivity
Pathology
Epithelial Cells
Adipose tissue
H&E, hematoxylin-eosin
Doença de Chagas
Trypanosoma cruzi
Células Epiteliais
Tecido Adiposo
title_short Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
title_full Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
title_fullStr Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
title_full_unstemmed Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
title_sort Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
author Lenzi, Henrique Leonel
author_facet Lenzi, Henrique Leonel
Oliveira, Denise N.
Lima, Morgana T.
Gattass, Cerli Rocha
author_role author
author2 Oliveira, Denise N.
Lima, Morgana T.
Gattass, Cerli Rocha
author2_role author
author
author
dc.contributor.author.fl_str_mv Lenzi, Henrique Leonel
Oliveira, Denise N.
Lima, Morgana T.
Gattass, Cerli Rocha
dc.subject.en.pt_BR.fl_str_mv Chagas’ disease
Trypanosoma cruzi
Protozoa
CL strain
Infectivity
Pathology
Epithelial Cells
Adipose tissue
H&E, hematoxylin-eosin
topic Chagas’ disease
Trypanosoma cruzi
Protozoa
CL strain
Infectivity
Pathology
Epithelial Cells
Adipose tissue
H&E, hematoxylin-eosin
Doença de Chagas
Trypanosoma cruzi
Células Epiteliais
Tecido Adiposo
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas
Trypanosoma cruzi
Células Epiteliais
Tecido Adiposo
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2012-12-14T17:03:20Z
dc.date.available.fl_str_mv 2012-12-14T17:03:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6002
dc.identifier.issn.none.fl_str_mv 0014-4894
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1006/expr.1996.0086
identifier_str_mv LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996.
0014-4894
url https://www.arca.fiocruz.br/handle/icict/6002
http://dx.doi.org/10.1006/expr.1996.0086
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
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