Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1996 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | http://dx.doi.org/10.1006/expr.1996.0086 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/6002 http://dx.doi.org/10.1006/expr.1996.0086 |
| Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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Lenzi, Henrique LeonelOliveira, Denise N.Lima, Morgana T.Gattass, Cerli Rocha2012-12-14T17:03:20Z2012-12-14T17:03:20Z1996LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996.0014-4894https://www.arca.fiocruz.br/handle/icict/6002http://dx.doi.org/10.1006/expr.1996.0086engAcademic PressTrypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia, Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia, Rio de Janeiro, RJ, BrasilA systematic study of the distribution of intracellular parasites in the organs and tissues of mice acutely infected (15 days) with the CL strain ofTrypanosoma cruziwas performed. Almost all tissues and organs were parasitized with different intensities, including several epithelial cell types. In addition to striated, cardiac, and smooth muscles a very high parasitism of fat cells, pancreas, and genital adnexa was observed. A smaller number of parasites was found in all other structures studied except in highly vascularized structures such as in the penile corpora cavernosa, pulmonary and renal parenchyma, islets of Langerhans, hepatic sinusoids, and in atrial endothelium. This paper also shows, for the first time in the literature, the parasitism of milky spots, cornea epithelium, cornea stroma, retroorbital fibroblasts, seminal vesicles, and coagulative, Cowper's, urethral, preputial, sebaceous anal, and clitoris glands. The results indicated that CL strain is highly invasive, being able to infect cells derived from the three embryonic layers (ectoderm, mesoderm, and endoderm), suggesting that the paninfectivity may influence the outcome of immunological and pathological events.Chagas’ diseaseTrypanosoma cruziProtozoaCL strainInfectivityPathologyEpithelial CellsAdipose tissueH&E, hematoxylin-eosinDoença de ChagasTrypanosoma cruziCélulas EpiteliaisTecido Adiposoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6002/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALTrypanosoma cruzi.pdfTrypanosoma cruzi.pdfapplication/pdf1479916https://www.arca.fiocruz.br/bitstream/icict/6002/2/Trypanosoma%20cruzi.pdf2a892f8476b3e66b591f602919510164MD52TEXTTrypanosoma cruzi.pdf.txtTrypanosoma cruzi.pdf.txtExtracted texttext/plain33804https://www.arca.fiocruz.br/bitstream/icict/6002/5/Trypanosoma%20cruzi.pdf.txt8b6be4261a0d9e17949b263265118bd2MD55THUMBNAILTrypanosoma cruzi.pdf.jpgTrypanosoma cruzi.pdf.jpgGenerated Thumbnailimage/jpeg1852https://www.arca.fiocruz.br/bitstream/icict/6002/4/Trypanosoma%20cruzi.pdf.jpgf1fdfb6be3d04849d982068160fadd59MD54icict/60022018-05-22 15:46:34.469oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-22T18:46:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| title |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| spellingShingle |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection Lenzi, Henrique Leonel Chagas’ disease Trypanosoma cruzi Protozoa CL strain Infectivity Pathology Epithelial Cells Adipose tissue H&E, hematoxylin-eosin Doença de Chagas Trypanosoma cruzi Células Epiteliais Tecido Adiposo |
| title_short |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| title_full |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| title_fullStr |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| title_full_unstemmed |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| title_sort |
Trypanosoma cruzi:Paninfectivity of CL Strain during Murine Acute Infection |
| author |
Lenzi, Henrique Leonel |
| author_facet |
Lenzi, Henrique Leonel Oliveira, Denise N. Lima, Morgana T. Gattass, Cerli Rocha |
| author_role |
author |
| author2 |
Oliveira, Denise N. Lima, Morgana T. Gattass, Cerli Rocha |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Henrique Leonel Oliveira, Denise N. Lima, Morgana T. Gattass, Cerli Rocha |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas’ disease Trypanosoma cruzi Protozoa CL strain Infectivity Pathology Epithelial Cells Adipose tissue H&E, hematoxylin-eosin |
| topic |
Chagas’ disease Trypanosoma cruzi Protozoa CL strain Infectivity Pathology Epithelial Cells Adipose tissue H&E, hematoxylin-eosin Doença de Chagas Trypanosoma cruzi Células Epiteliais Tecido Adiposo |
| dc.subject.decs.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Células Epiteliais Tecido Adiposo |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
1996 |
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1996 |
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2012-12-14T17:03:20Z |
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2012-12-14T17:03:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996. |
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https://www.arca.fiocruz.br/handle/icict/6002 |
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0014-4894 |
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http://dx.doi.org/10.1006/expr.1996.0086 |
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LENZI, H. L. et al. Trypanosoma cruzi: painfectivity of CL strain during murine acute infection. Experimental Parasitology, v. 84, n. 1. p. 16-27, 1996. 0014-4894 |
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https://www.arca.fiocruz.br/handle/icict/6002 http://dx.doi.org/10.1006/expr.1996.0086 |
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