Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease

Detalhes bibliográficos
Autor(a) principal: Trindade, Bruno Caetano
Data de Publicação: 2012
Outros Autores: Faccioli, Lúcia Helena, Martins Filho, Olindo Assis, Nicolete, Larissa Deadame de Figueiredo, Malta, Tathiane Maistro, Pinto, Mariana Tomazini, Kashima, Simone Haddad, Takayanagui, Osvaldo Massaiti, Covas, Dimas Tadeu, Sorgi, Carlos Artério
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7990
Resumo: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, Brazil/Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
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spelling Trindade, Bruno CaetanoFaccioli, Lúcia HelenaMartins Filho, Olindo AssisNicolete, Larissa Deadame de FigueiredoMalta, Tathiane MaistroPinto, Mariana TomaziniKashima, Simone HaddadTakayanagui, Osvaldo MassaitiCovas, Dimas TadeuSorgi, Carlos Artério2014-07-17T18:44:36Z2014-07-17T18:44:36Z2012TRINDADE, Bruno Caetano et al. Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease. Plos One. 2012, vol.7, pp. e518731932-620310.1371/journal.pone.0051873https://www.arca.fiocruz.br/handle/icict/7990engPublic Library of ScienceLeukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, Brazil/Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, BrazilFundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilInstituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrazilInstituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrazilInstituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrazilInstituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Neurociências e Ciências do Comportamento. Ribeirão Preto, SP, BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Ribeirão Preto, SP, Brazil/ Instituto Nacional de Ciência e Tecnologia em Células-Tronco e Terapia Celular/Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrazilLeukotrienes (LTs) are lipid mediators involved in several inflammatory disorders. We investigated the LT pathway in human T-lymphotropic virus type 1 (HTLV-1) infection by evaluating LT levels in HTLV-1-infected patients classified according to the clinical status as asymptomatic carriers (HACs) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Bioactive LTB4 and CysLTs were both increased in the plasma and in the supernatant of peripheral blood mononuclear cell cultures of HTLV-1-infected when compared to non-infected. Interestingly, CysLT concentrations were increased in HAM/TSP patients. Also, the concentration of plasma LTB4 and LTC4 positively correlated with the HTLV-1 proviral load in HTLV-1-infected individuals. The gene expression levels of LT receptors were differentially modulated in CD4+ and CD8+ T cells of HTLV-1-infected patients. Analysis of the overall plasma signature of immune mediators demonstrated that LT and chemokine amounts were elevated during HTLV-1 infection. Importantly, in addition to CysLTs, IP-10 was also identified as a biomarker for HAM/TSP activity. These data suggest that LTs are likely to be associated with HTLV-1 infection and HAM/TSP development, suggesting their putative use for clinical monitoring.inflammatory disordersLeukotrienesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLeukotrienes Are Upregulated and Associated with Human T-Lymphotropic Virus Type 1 (HTLV-1)-Associated Neuroinflammatory Disease.pdfLeukotrienes Are Upregulated and Associated with Human T-Lymphotropic Virus Type 1 (HTLV-1)-Associated Neuroinflammatory Disease.pdfapplication/pdf1890744https://www.arca.fiocruz.br/bitstream/icict/7990/1/Leukotrienes%20Are%20Upregulated%20and%20Associated%20with%20Human%20T-Lymphotropic%20Virus%20Type%201%20%28HTLV-1%29-Associated%20Neuroinflammatory%20Disease.pdf0e62a72ff13943f2fa4f65d537cff875MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7990/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTLeukotrienes Are Upregulated and Associated with Human T-Lymphotropic Virus Type 1 (HTLV-1)-Associated Neuroinflammatory Disease.pdf.txtLeukotrienes Are Upregulated and Associated with Human T-Lymphotropic Virus Type 1 (HTLV-1)-Associated Neuroinflammatory Disease.pdf.txtExtracted texttext/plain11https://www.arca.fiocruz.br/bitstream/icict/7990/3/Leukotrienes%20Are%20Upregulated%20and%20Associated%20with%20Human%20T-Lymphotropic%20Virus%20Type%201%20%28HTLV-1%29-Associated%20Neuroinflammatory%20Disease.pdf.txtb308b7fe5c1c2bbdc0cb686d451b84aaMD53icict/79902018-04-05 23:45:29.923oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T02:45:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
title Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
spellingShingle Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
Trindade, Bruno Caetano
inflammatory disorders
Leukotrienes
title_short Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
title_full Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
title_fullStr Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
title_full_unstemmed Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
title_sort Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease
author Trindade, Bruno Caetano
author_facet Trindade, Bruno Caetano
Faccioli, Lúcia Helena
Martins Filho, Olindo Assis
Nicolete, Larissa Deadame de Figueiredo
Malta, Tathiane Maistro
Pinto, Mariana Tomazini
Kashima, Simone Haddad
Takayanagui, Osvaldo Massaiti
Covas, Dimas Tadeu
Sorgi, Carlos Artério
author_role author
author2 Faccioli, Lúcia Helena
Martins Filho, Olindo Assis
Nicolete, Larissa Deadame de Figueiredo
Malta, Tathiane Maistro
Pinto, Mariana Tomazini
Kashima, Simone Haddad
Takayanagui, Osvaldo Massaiti
Covas, Dimas Tadeu
Sorgi, Carlos Artério
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Trindade, Bruno Caetano
Faccioli, Lúcia Helena
Martins Filho, Olindo Assis
Nicolete, Larissa Deadame de Figueiredo
Malta, Tathiane Maistro
Pinto, Mariana Tomazini
Kashima, Simone Haddad
Takayanagui, Osvaldo Massaiti
Covas, Dimas Tadeu
Sorgi, Carlos Artério
dc.subject.en.pt_BR.fl_str_mv inflammatory disorders
Leukotrienes
topic inflammatory disorders
Leukotrienes
description Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Inflamação e Imunologia das Parasitoses. Ribeirão Preto, SP, Brazil/Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-17T18:44:36Z
dc.date.available.fl_str_mv 2014-07-17T18:44:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TRINDADE, Bruno Caetano et al. Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease. Plos One. 2012, vol.7, pp. e51873
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7990
dc.identifier.issn.none.fl_str_mv 1932-6203
10.1371/journal.pone.0051873
identifier_str_mv TRINDADE, Bruno Caetano et al. Leukotrienes are upregulated and associated with human T-Lymphotropic virus type 1 (HTLV-1)-associated neuroinflammatory disease. Plos One. 2012, vol.7, pp. e51873
1932-6203
10.1371/journal.pone.0051873
url https://www.arca.fiocruz.br/handle/icict/7990
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7990/1/Leukotrienes%20Are%20Upregulated%20and%20Associated%20with%20Human%20T-Lymphotropic%20Virus%20Type%201%20%28HTLV-1%29-Associated%20Neuroinflammatory%20Disease.pdf
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