The cursed duet today: Tuberculosis and HIV-coinfection

Detalhes bibliográficos
Autor(a) principal: Tiberi, Simon
Data de Publicação: 2017
Outros Autores: Carvalho, Anna Cristina C., Sulis, Giorgia, Vaghela, Devan, Rendon, Adrian, Mello, Fernanda C. de Q., Rahman, Ananna, Matin, Nashaba, Zumla, Ali, Pontali, Emanuele
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25016
Resumo: Barts health NHS Trust. Royal London hospital. Division of Infection. London, United Kingdom.
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spelling Tiberi, SimonCarvalho, Anna Cristina C.Sulis, GiorgiaVaghela, DevanRendon, AdrianMello, Fernanda C. de Q.Rahman, AnannaMatin, NashabaZumla, AliPontali, Emanuele2018-03-01T13:56:41Z2018-03-01T13:56:41Z2017TIBERI, Simon; et al. The cursed duet today: Tuberculosis and HIV-coinfection. Presse Med., v.46, e23–e39, 2017.0481-2158https://www.arca.fiocruz.br/handle/icict/2501610.1016/j.lpm.2017.01.017engElsevier MassonTuberculoseHIVCo-infecçãoTuberculosisHIV-coinfectionThe cursed duet today: Tuberculosis and HIV-coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBarts health NHS Trust. Royal London hospital. Division of Infection. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.University of Brescia. Department of Infectious and Tropical Diseases. Brescia, Italy.Barts Health NHS Trust. Royal London hospital. Department of Respiratory Medicine. London, United Kingdom.Hospital Universitario de Monterrey. Centro de Investigación, Prevención yTratamiento de Infecciones Respiratorias., Monterrey, Nuevo León Mexico.Universidade Federal do Rio de Janeiro. Instituto de Doenças do Tórax. Rio de Janeiro, RJ, Brasil.Papworth Hospital NHS Foundation Trust. Department of Respiratory Medicine. Cambridge, United Kingdom.Barts Health NHS Trust. Royal London hospital. HIV Medicine, Infection and Immunity. London, United Kingdom.UCL Hospitals NHS Foundation Trust. University College London. NIHR Biomedical Research Centre. Division of Infection and Immunity. London, United Kingdom.Galliera Hospital. Department of Infectious Diseases. Genoa, Italy.The tuberculosis (TB) and HIV syndemic continues to rage and are a major public health concern worldwide. This deadly association raises complexity and represent a significant barrier towards TB elimination. TB continues to be the leading cause of death amongst HIV-infected people. This paper reports the challenges that lay ahead and outlines some of the current and future strategies that may be able to address this co-epidemic efficiently. Improved diagnostics, cheaper and more effective drugs, shorter treatment regimens for both drug-sensitive and drug-resistant TB are discussed. Also, special topics on drug interactions, TB-IRIS and TB relapse are also described. Notwithstanding the defeats and meagre investments, diagnosis and management of the two diseases have seen significant and unexpected improvements of late. On the HIV side, expansion of ART coverage, development of new updated guidelines aimed at the universal treatment of those infected, and the increasing availability of newer, more efficacious and less toxic drugs are an essential element to controlling the two epidemics. On the TB side, diagnosis of MDR-TB is becoming easier and faster thanks to the new PCR-based technologies, new anti-TB drugs active against both sensitive and resistant strains (i.e. bedaquiline and delamanid) have been developed and a few more are in the pipeline, new regimens (cheaper, shorter and/or more effective) have been introduced (such as the "Bangladesh regimen") or are being tested for MDR-TB and drug-sensitive-TB. However, still more resources will be required to implement an integrated approach, install new diagnostic tests, and develop simpler and shorter treatment regimens.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25016/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanna_carvalho_etal_IOC_2017.pdfanna_carvalho_etal_IOC_2017.pdfapplication/pdf656489https://www.arca.fiocruz.br/bitstream/icict/25016/2/anna_carvalho_etal_IOC_2017.pdf02ee7e97d025a9bf4584c7f204a042a3MD52TEXTanna_carvalho_etal_IOC_2017.pdf.txtanna_carvalho_etal_IOC_2017.pdf.txtExtracted texttext/plain99692https://www.arca.fiocruz.br/bitstream/icict/25016/3/anna_carvalho_etal_IOC_2017.pdf.txt34d072abfd34008a9e5b6b454186d7e7MD53icict/250162018-08-15 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dc.title.pt_BR.fl_str_mv The cursed duet today: Tuberculosis and HIV-coinfection
title The cursed duet today: Tuberculosis and HIV-coinfection
spellingShingle The cursed duet today: Tuberculosis and HIV-coinfection
Tiberi, Simon
Tuberculose
HIV
Co-infecção
Tuberculosis
HIV-coinfection
title_short The cursed duet today: Tuberculosis and HIV-coinfection
title_full The cursed duet today: Tuberculosis and HIV-coinfection
title_fullStr The cursed duet today: Tuberculosis and HIV-coinfection
title_full_unstemmed The cursed duet today: Tuberculosis and HIV-coinfection
title_sort The cursed duet today: Tuberculosis and HIV-coinfection
author Tiberi, Simon
author_facet Tiberi, Simon
Carvalho, Anna Cristina C.
Sulis, Giorgia
Vaghela, Devan
Rendon, Adrian
Mello, Fernanda C. de Q.
Rahman, Ananna
Matin, Nashaba
Zumla, Ali
Pontali, Emanuele
author_role author
author2 Carvalho, Anna Cristina C.
Sulis, Giorgia
Vaghela, Devan
Rendon, Adrian
Mello, Fernanda C. de Q.
Rahman, Ananna
Matin, Nashaba
Zumla, Ali
Pontali, Emanuele
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tiberi, Simon
Carvalho, Anna Cristina C.
Sulis, Giorgia
Vaghela, Devan
Rendon, Adrian
Mello, Fernanda C. de Q.
Rahman, Ananna
Matin, Nashaba
Zumla, Ali
Pontali, Emanuele
dc.subject.other.pt_BR.fl_str_mv Tuberculose
HIV
Co-infecção
topic Tuberculose
HIV
Co-infecção
Tuberculosis
HIV-coinfection
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
HIV-coinfection
description Barts health NHS Trust. Royal London hospital. Division of Infection. London, United Kingdom.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-01T13:56:41Z
dc.date.available.fl_str_mv 2018-03-01T13:56:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv TIBERI, Simon; et al. The cursed duet today: Tuberculosis and HIV-coinfection. Presse Med., v.46, e23–e39, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25016
dc.identifier.issn.pt_BR.fl_str_mv 0481-2158
dc.identifier.doi.none.fl_str_mv 10.1016/j.lpm.2017.01.017
identifier_str_mv TIBERI, Simon; et al. The cursed duet today: Tuberculosis and HIV-coinfection. Presse Med., v.46, e23–e39, 2017.
0481-2158
10.1016/j.lpm.2017.01.017
url https://www.arca.fiocruz.br/handle/icict/25016
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Masson
publisher.none.fl_str_mv Elsevier Masson
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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