Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)

Detalhes bibliográficos
Autor(a) principal: Swindells, Susan
Data de Publicação: 2018
Outros Autores: Gupta, Amita, Kim, Soyeon, Hughes, Michael D., Sanchez, Jorge, Mave, Vidya, Dawson, Rodney, Kumarasamy, Nagalingeswaran, Comins, Kyla, Smith, Betsy, Rustomjee, Roxana, Naini, Linda, Shah, N. Sarita, Hesseling, Anneke, Churchyard, Gavin, ACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37892
Resumo: Ana Cristina Garcia Ferreira / Maria Regina Rocha. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. (Site12101) Grant 5UM1AI069476–09.
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spelling Swindells, SusanGupta, AmitaKim, SoyeonHughes, Michael D.Sanchez, JorgeMave, VidyaDawson, RodneyKumarasamy, NagalingeswaranComins, KylaSmith, BetsyRustomjee, RoxanaNaini, LindaShah, N. SaritaHesseling, AnnekeChurchyard, GavinACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team2019-12-12T13:07:13Z2019-12-12T13:07:13Z2018SWINDELLS, Susan et al. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). International Journal of Tuberculosis and Lung Disease, v. 22, n. 9, p. 1016-1022, Sept. 2018.1027-3719https://www.arca.fiocruz.br/handle/icict/3789210.5588/ijtld.18.01631815-7920Ana Cristina Garcia Ferreira / Maria Regina Rocha. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. (Site12101) Grant 5UM1AI069476–09.2020-06-12University of Nebraska Medical Center. Omaha, NE, USA.Johns Hopkins University. School of Medicine. Baltimore, MD, USA.Frontier Science Foundation. Brookline, MA, USA.Harvard T. H. Chan School of Public Health. Boston, MA, USA.Asociación Civil Impacta Salud y Educación. Lima, Peru.Byramjee Jeejeebhoy Government Medical College CRS. Pune, India.University of Cape Town Lung Institute. Cape Town, South Africa.Chennai Antiviral Research and Treatment CRS. Chennai, India.TASK Applied Science Clinical Research Site. Bellville, South Africa.National Institutes of Health. Bethesda, MD, USA.National Institutes of Health. Bethesda, MD, USA.Social & Scientific Systems, Inc. Silver Springs, MD, USA.Centers for Disease Control and Prevention. Atlanta, GA, USA.Desmond Tutu TB Centre, Stellenbosch University. Tygerberg, South Africa.The Aurum Institute. Johannesburg, South Africa / University of Witwatersrand. School of Public Health. Johannesburg, South Africa / South African Medical Research Council. Advancing Care and Treatment for TB and HIV. Johannesburg. South Africa.Background: Current guidelines recommend evaluation of household contacts (HHC) of individuals with multidrug-resistant tuberculosis (MDR-TB) but widespread implementation of this policy is challenging. Objective: To describe site-level resource utilization and operational challenges encountered when identifying, recruiting, and characterizing adult MDR-TB Index Cases and their HHC. Design: Cross-sectional study of adult MDR-TB Index Cases and HHC at 16 clinical research sites in 8 countries. Site-level resource utilization was assessed using structured surveys. Results: Between October 2015 and April 2016, 308 Index Cases and 1018 HHC were enrolled. Of 280 Index Cases with sputum collected, 94 were smear positive (34%, 95% Confidence Interval (CI): 28–39%) and of 201 with chest x-rays, 87 had cavitary disease (43%, CI: 37–50%) after a mean duration of treatment of 8 weeks. Staff required 512 attempts to evaluate the 308 households, median time per attempt of 4 hours. 77% (CI: 73─80%) of the HHC were at increased risk for TB: 13% < 5 years; 8% >5 years. and HIV-infected; and 79% >5 years, HIV-/unknown and TST/IGRA positive. 121 previously undiagnosed TB cases were identified. Issues identified by site staff included complexity of personnel and participant transportation, infection control, personnel safety and management of stigma surrounding household visits. Conclusion: Household contact investigations can be high yield but are labor intensive.engInternational Union Against Tuberculosis and Lung DiseaseResource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMDR-TBHousehold contact investigationResource utilizationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/37892/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALva_Swindells_Susan_etal_INI_2018.pdfva_Swindells_Susan_etal_INI_2018.pdfapplication/pdf350838https://www.arca.fiocruz.br/bitstream/icict/37892/2/va_Swindells_Susan_etal_INI_2018.pdf6a8b380aabd0b5054a8712a100eae24cMD52TEXTva_Swindells_Susan_etal_INI_2018.pdf.txtva_Swindells_Susan_etal_INI_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
title Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
spellingShingle Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
Swindells, Susan
MDR-TB
Household contact investigation
Resource utilization
title_short Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
title_full Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
title_fullStr Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
title_full_unstemmed Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
title_sort Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)
author Swindells, Susan
author_facet Swindells, Susan
Gupta, Amita
Kim, Soyeon
Hughes, Michael D.
Sanchez, Jorge
Mave, Vidya
Dawson, Rodney
Kumarasamy, Nagalingeswaran
Comins, Kyla
Smith, Betsy
Rustomjee, Roxana
Naini, Linda
Shah, N. Sarita
Hesseling, Anneke
Churchyard, Gavin
ACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team
author_role author
author2 Gupta, Amita
Kim, Soyeon
Hughes, Michael D.
Sanchez, Jorge
Mave, Vidya
Dawson, Rodney
Kumarasamy, Nagalingeswaran
Comins, Kyla
Smith, Betsy
Rustomjee, Roxana
Naini, Linda
Shah, N. Sarita
Hesseling, Anneke
Churchyard, Gavin
ACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Swindells, Susan
Gupta, Amita
Kim, Soyeon
Hughes, Michael D.
Sanchez, Jorge
Mave, Vidya
Dawson, Rodney
Kumarasamy, Nagalingeswaran
Comins, Kyla
Smith, Betsy
Rustomjee, Roxana
Naini, Linda
Shah, N. Sarita
Hesseling, Anneke
Churchyard, Gavin
ACTG5300/IMPAACT2003 PHOENIx Feasibility Study Team
dc.subject.en.pt_BR.fl_str_mv MDR-TB
Household contact investigation
Resource utilization
topic MDR-TB
Household contact investigation
Resource utilization
description Ana Cristina Garcia Ferreira / Maria Regina Rocha. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. (Site12101) Grant 5UM1AI069476–09.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-12-12T13:07:13Z
dc.date.available.fl_str_mv 2019-12-12T13:07:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SWINDELLS, Susan et al. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). International Journal of Tuberculosis and Lung Disease, v. 22, n. 9, p. 1016-1022, Sept. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37892
dc.identifier.issn.pt_BR.fl_str_mv 1027-3719
dc.identifier.doi.none.fl_str_mv 10.5588/ijtld.18.0163
dc.identifier.eissn.none.fl_str_mv 1815-7920
identifier_str_mv SWINDELLS, Susan et al. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). International Journal of Tuberculosis and Lung Disease, v. 22, n. 9, p. 1016-1022, Sept. 2018.
1027-3719
10.5588/ijtld.18.0163
1815-7920
url https://www.arca.fiocruz.br/handle/icict/37892
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv International Union Against Tuberculosis and Lung Disease
publisher.none.fl_str_mv International Union Against Tuberculosis and Lung Disease
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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