Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives

Detalhes bibliográficos
Autor(a) principal: Vargas, Gabriele
Data de Publicação: 2020
Outros Autores: Geraldo, Luiz Henrique Medeiros, Salomão, Natália Gedeão, Paes, Marciano Viana, Lima, Flavia Regina Souza, Gomes, Flávia Carvalho Alcantara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43095
Resumo: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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spelling Vargas, GabrieleGeraldo, Luiz Henrique MedeirosSalomão, Natália GedeãoPaes, Marciano VianaLima, Flavia Regina SouzaGomes, Flávia Carvalho Alcantara2020-08-31T21:36:40Z2020-08-31T21:36:40Z2020VARGAS, Gabriele et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives. Brain, Behavior, & Immunity - Health, v. 7, 100127, p. 1-13, 2020.2666-3546https://www.arca.fiocruz.br/handle/icict/4309510.1016/j.bbih.2020.100127Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Université de Paris. Paris Cardiovascular Research Center (PARCC - INSERM U970). Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.In December 2019, a pneumonia outbreak was reported in Wuhan, Hubei province, China. Since then, the World Health Organization declared a public health emergency of international concern due to a growing number of deaths around the globe, as well as unparalleled economic and sociodemographic consequences. The disease called coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), a novel form of human coronavirus. Although coronavirus infections have been associated with neurological manifestations such as febrile seizures, convulsions, change in mental status, and encephalitis, less is known about the impact of SARS-CoV-2 in the brain. Recently, emerging evidence suggests that SARS-CoV-2 is associated with neurological alterations in COVID-19 patients with severe clinical manifestations. The molecular and cellular mechanisms involved in this process, as well as the neurotropic and neuroinvasive properties of SARS-CoV-2, are still poorly understood. Glial cells, such as astrocytes and microglia, play pivotal roles in the brain response to neuroinflammatory insults and neurodegenerative diseases. Further, accumulating evidence has shown that those cells are targets of several neurotropic viruses that severely impact their function. Glial cell dysfunctions have been associated with several neuroinflammatory diseases, suggesting that SARS-CoV-2 likely has a primary effect on these cells in addition to a secondary effect from neuronal damage. Here, we provide an overview of these data and discuss the possible implications of glial cells as targets of SARS-CoV-2. Considering the roles of microglia and astrocytes in brain inflammatory responses, we shed light on glial cells as possible drivers and potential targets of therapeutic strategies against neurological manifestations in patients with COVID19. The main goal of this review is to highlight the need to consider glial involvement in the progression of COVID-19 and potentially include astrocytes and microglia as mediators of SARS-CoV-2-induced neurological damage.engElsevierSARS-CoV-2COVID-19CoronavírusNeuroinflamaçãoNeurogliaAstrócitosMicrogliaGlial cellsAstrocyteMicrogliaSARS-CoV-2COVID-19CoronavirusNeuroinflammationNeurogliaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
title Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
spellingShingle Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
Vargas, Gabriele
SARS-CoV-2
COVID-19
Coronavírus
Neuroinflamação
Neuroglia
Astrócitos
Microglia
Glial cells
Astrocyte
Microglia
SARS-CoV-2
COVID-19
Coronavirus
Neuroinflammation
Neuroglia
title_short Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
title_full Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
title_fullStr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
title_full_unstemmed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
title_sort Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives
author Vargas, Gabriele
author_facet Vargas, Gabriele
Geraldo, Luiz Henrique Medeiros
Salomão, Natália Gedeão
Paes, Marciano Viana
Lima, Flavia Regina Souza
Gomes, Flávia Carvalho Alcantara
author_role author
author2 Geraldo, Luiz Henrique Medeiros
Salomão, Natália Gedeão
Paes, Marciano Viana
Lima, Flavia Regina Souza
Gomes, Flávia Carvalho Alcantara
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vargas, Gabriele
Geraldo, Luiz Henrique Medeiros
Salomão, Natália Gedeão
Paes, Marciano Viana
Lima, Flavia Regina Souza
Gomes, Flávia Carvalho Alcantara
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
Coronavírus
Neuroinflamação
Neuroglia
Astrócitos
Microglia
topic SARS-CoV-2
COVID-19
Coronavírus
Neuroinflamação
Neuroglia
Astrócitos
Microglia
Glial cells
Astrocyte
Microglia
SARS-CoV-2
COVID-19
Coronavirus
Neuroinflammation
Neuroglia
dc.subject.en.pt_BR.fl_str_mv Glial cells
Astrocyte
Microglia
SARS-CoV-2
COVID-19
Coronavirus
Neuroinflammation
dc.subject.decs.pt_BR.fl_str_mv Neuroglia
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-31T21:36:40Z
dc.date.available.fl_str_mv 2020-08-31T21:36:40Z
dc.date.issued.fl_str_mv 2020
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dc.identifier.citation.fl_str_mv VARGAS, Gabriele et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives. Brain, Behavior, & Immunity - Health, v. 7, 100127, p. 1-13, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43095
dc.identifier.issn.pt_BR.fl_str_mv 2666-3546
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.bbih.2020.100127
identifier_str_mv VARGAS, Gabriele et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives. Brain, Behavior, & Immunity - Health, v. 7, 100127, p. 1-13, 2020.
2666-3546
10.1016/j.bbih.2020.100127
url https://www.arca.fiocruz.br/handle/icict/43095
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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