NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria

Detalhes bibliográficos
Autor(a) principal: Bertinaria, Massimo
Data de Publicação: 2015
Outros Autores: Orjuela-Sanchez, Pamela, Marini, Elisabetta, Guglielmo, Stefano, Hofer, Anthony, Martins, Yuri C., Zanini, Graziela M., Frangos, John A., Gasco, Alberto, Fruttero, Roberta, Carvalho, Leonardo J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1021/acs.jmedchem.5b01036
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34929
Resumo: 2020-08-21
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spelling Bertinaria, MassimoOrjuela-Sanchez, PamelaMarini, ElisabettaGuglielmo, StefanoHofer, AnthonyMartins, Yuri C.Zanini, Graziela M.Frangos, John A.Gasco, AlbertoFruttero, RobertaCarvalho, Leonardo J. M.2019-08-21T14:34:23Z2019-08-21T14:34:23Z2015BERTINARIA, Massimo et al. NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria. Journal of Medicinal Chemistry, v. 58, n. 19, p. 7895-7899, Oct. 2015.0022-2623https://www.arca.fiocruz.br/handle/icict/3492910.1021/acs.jmedchem.5b010361520-4804engAmerican Chemical SocietyNO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-21Università degli Studi di Torino. Dipartimento di Scienza e Tecnologia del Farmaco. Torino, Italy.La Jolla Bioengineering Institute. La Jolla, CA, USA.Università degli Studi di Torino. Dipartimento di Scienza e Tecnologia del Farmaco. Torino, Italy.Università degli Studi di Torino. Dipartimento di Scienza e Tecnologia del Farmaco. Torino, Italy.La Jolla Bioengineering Institute. La Jolla, CA, USA.La Jolla Bioengineering Institute. La Jolla, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Laboratório de Parasitologia. Rio de Janeiro, RJ, Brasil.La Jolla Bioengineering Institute. La Jolla, CA, USA.Università degli Studi di Torino. Dipartimento di Scienza e Tecnologia del Farmaco. Torino, Italy.Università degli Studi di Torino. Dipartimento di Scienza e Tecnologia del Farmaco. Torino, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Hybrid products in which the dihydroartemisinin scaffold is combined with NO-donor furoxan and NONOate moieties have been synthesized and studied as potential tools for the treatment of cerebral malaria (CM). The designed products were able to dilate rat aorta strips precontracted with phenylephrine with a NO-dependent mechanism. All hybrid compounds showed preserved antiplasmodial activity in vitro and in vivo against Plasmodium berghei ANKA, comparable to artesunate and artemether. Hybrid 10, selected for additional studies, was capable of increasing survival of mice with late-stage CM from 27.5% to 51.6% compared with artemether. Artemisinin-NO-donor hybrid compounds show promise as potential new drugs for treating cerebral malaria.MalariaCerebral MalariaTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34929/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Bertinaria_Massimo_etal_INI_2015.pdfve_Bertinaria_Massimo_etal_INI_2015.pdfapplication/pdf1696162https://www.arca.fiocruz.br/bitstream/icict/34929/2/ve_Bertinaria_Massimo_etal_INI_2015.pdf33ea14f7200bb0e6892c393798af629dMD52TEXTve_Bertinaria_Massimo_etal_INI_2015.pdf.txtve_Bertinaria_Massimo_etal_INI_2015.pdf.txtExtracted texttext/plain25657https://www.arca.fiocruz.br/bitstream/icict/34929/3/ve_Bertinaria_Massimo_etal_INI_2015.pdf.txte7b489c22530b4f518aebcf1185de402MD53icict/349292021-03-24 16:32:35.593oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
title NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
spellingShingle NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
Bertinaria, Massimo
Malaria
Cerebral Malaria
Treatment
title_short NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
title_full NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
title_fullStr NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
title_full_unstemmed NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
title_sort NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria
author Bertinaria, Massimo
author_facet Bertinaria, Massimo
Orjuela-Sanchez, Pamela
Marini, Elisabetta
Guglielmo, Stefano
Hofer, Anthony
Martins, Yuri C.
Zanini, Graziela M.
Frangos, John A.
Gasco, Alberto
Fruttero, Roberta
Carvalho, Leonardo J. M.
author_role author
author2 Orjuela-Sanchez, Pamela
Marini, Elisabetta
Guglielmo, Stefano
Hofer, Anthony
Martins, Yuri C.
Zanini, Graziela M.
Frangos, John A.
Gasco, Alberto
Fruttero, Roberta
Carvalho, Leonardo J. M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bertinaria, Massimo
Orjuela-Sanchez, Pamela
Marini, Elisabetta
Guglielmo, Stefano
Hofer, Anthony
Martins, Yuri C.
Zanini, Graziela M.
Frangos, John A.
Gasco, Alberto
Fruttero, Roberta
Carvalho, Leonardo J. M.
dc.subject.en.pt_BR.fl_str_mv Malaria
Cerebral Malaria
Treatment
topic Malaria
Cerebral Malaria
Treatment
description 2020-08-21
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-21T14:34:23Z
dc.date.available.fl_str_mv 2019-08-21T14:34:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BERTINARIA, Massimo et al. NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria. Journal of Medicinal Chemistry, v. 58, n. 19, p. 7895-7899, Oct. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34929
dc.identifier.issn.pt_BR.fl_str_mv 0022-2623
dc.identifier.doi.none.fl_str_mv 10.1021/acs.jmedchem.5b01036
dc.identifier.eissn.none.fl_str_mv 1520-4804
identifier_str_mv BERTINARIA, Massimo et al. NO-donor dihydroartemisinin derivatives as multitarget agents for the treatment of cerebral malaria. Journal of Medicinal Chemistry, v. 58, n. 19, p. 7895-7899, Oct. 2015.
0022-2623
10.1021/acs.jmedchem.5b01036
1520-4804
url https://www.arca.fiocruz.br/handle/icict/34929
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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