Bacillus Calmette–Guérin immunotherapy for cancer

Detalhes bibliográficos
Autor(a) principal: Cardillo, Fabíola
Data de Publicação: 2021
Outros Autores: Bonfim, Maiara, Sousa, Periela da Silva Vasconcelos, Mengel, José, Castello-Branco, Luiz Roberto Ribeiro, Pinho, Rosa Teixeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47812
Resumo: FIOCRUZ
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spelling Cardillo, FabíolaBonfim, MaiaraSousa, Periela da Silva VasconcelosMengel, JoséCastello-Branco, Luiz Roberto RibeiroPinho, Rosa Teixeira2021-06-21T18:17:05Z2021-06-21T18:17:05Z2021CARDILLO, Fabíola et al. Bacillus Calmette–Guérin immunotherapy for cancer. Vaccines, v. 9, n. 5, p. 1-15, 1 May 2021.2076-393Xhttps://www.arca.fiocruz.br/handle/icict/4781210.3390/vaccines9050439FIOCRUZFundação Ataulpho de Paiva (FAP)National Institutes of Science and Technology in Tuberculosis (INCT)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Estrutural e Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Estrutural e Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Virologia Molecular e Biotecnologia Marinha. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculdade de Medicina de Petrópolis. Petrópolis, RJ, Brasil.Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Bacillus Calmette–Guérin (BCG), an attenuated vaccine from Mycobacterium bovis, was initially developed as an agent for vaccination against tuberculosis. BCG proved to be the first successful immunotherapy against established human bladder cancer and other neoplasms. The use of BCG has been shown to induce a long-lasting antitumor response over all other forms of treatment against intermediate, non-invasive muscle bladder cancer Several types of tumors may now be treated by releasing the immune response through the blockade of checkpoint inhibitory molecules, such as CTLA-4 and PD-1. In addition, Toll-Like Receptor (TLR) agonists and BCG are used to potentiate the immune response against tumors. Studies concerning TLR-ligands combined with BCG to treat melanoma have demonstrated efficacy in treating mice and patients This review addresses several interventions using BCG on neoplasms, such as Leukemia, Bladder Cancer, Lung Cancer, and Melanoma, describing treatments and antitumor responses promoted by this attenuated bacillus. Of essential importance, BCG is described recently to participate in an adequate microbiome, establishing an effective response during cell-target therapy when combined with anti-PD-1 antibody, which stimulates T cell responses against the melanoma. Finally, trained immunity is discussed, and reprogramming events to shape innate immune responses are addressed.engMDPIBCGCâncerImunidadeMycobacterium bovisNeoplasiasBCGCancerTrained immunityBacillus Calmette–Guérin immunotherapy for cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47812/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCardillo, Fabiola Bacillus calmette....pdfCardillo, Fabiola Bacillus calmette....pdfapplication/pdf360322https://www.arca.fiocruz.br/bitstream/icict/47812/2/Cardillo%2c%20Fabiola%20Bacillus%20calmette....pdfb6bd3fa52167da855fb66b44411ed875MD52TEXTCardillo, Fabiola Bacillus calmette....pdf.txtCardillo, Fabiola Bacillus calmette....pdf.txtExtracted 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dc.title.en.fl_str_mv Bacillus Calmette–Guérin immunotherapy for cancer
title Bacillus Calmette–Guérin immunotherapy for cancer
spellingShingle Bacillus Calmette–Guérin immunotherapy for cancer
Cardillo, Fabíola
BCG
Câncer
Imunidade
Mycobacterium bovis
Neoplasias
BCG
Cancer
Trained immunity
title_short Bacillus Calmette–Guérin immunotherapy for cancer
title_full Bacillus Calmette–Guérin immunotherapy for cancer
title_fullStr Bacillus Calmette–Guérin immunotherapy for cancer
title_full_unstemmed Bacillus Calmette–Guérin immunotherapy for cancer
title_sort Bacillus Calmette–Guérin immunotherapy for cancer
author Cardillo, Fabíola
author_facet Cardillo, Fabíola
Bonfim, Maiara
Sousa, Periela da Silva Vasconcelos
Mengel, José
Castello-Branco, Luiz Roberto Ribeiro
Pinho, Rosa Teixeira
author_role author
author2 Bonfim, Maiara
Sousa, Periela da Silva Vasconcelos
Mengel, José
Castello-Branco, Luiz Roberto Ribeiro
Pinho, Rosa Teixeira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cardillo, Fabíola
Bonfim, Maiara
Sousa, Periela da Silva Vasconcelos
Mengel, José
Castello-Branco, Luiz Roberto Ribeiro
Pinho, Rosa Teixeira
dc.subject.other.pt_BR.fl_str_mv BCG
Câncer
Imunidade
Mycobacterium bovis
Neoplasias
topic BCG
Câncer
Imunidade
Mycobacterium bovis
Neoplasias
BCG
Cancer
Trained immunity
dc.subject.en.en.fl_str_mv BCG
Cancer
Trained immunity
description FIOCRUZ
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-21T18:17:05Z
dc.date.available.fl_str_mv 2021-06-21T18:17:05Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDILLO, Fabíola et al. Bacillus Calmette–Guérin immunotherapy for cancer. Vaccines, v. 9, n. 5, p. 1-15, 1 May 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47812
dc.identifier.issn.pt_BR.fl_str_mv 2076-393X
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/vaccines9050439
identifier_str_mv CARDILLO, Fabíola et al. Bacillus Calmette–Guérin immunotherapy for cancer. Vaccines, v. 9, n. 5, p. 1-15, 1 May 2021.
2076-393X
10.3390/vaccines9050439
url https://www.arca.fiocruz.br/handle/icict/47812
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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