Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/tropicalmed5020076 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42423 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Hasslocher-Moreno, Alejandro MarcelXavier, Sergio SallesSaraiva, Roberto MagalhãesSangenis, Luiz Henrique CondeHolanda, Marcelo Teixeira deVeloso, Henrique HortaCosta, Andrea Rodrigues daMendes, Fernanda de Souza Nogueira SardinhaBrasil, Pedro Emmanuel Alvarenga Americano doSilva, Gilberto Marcelo Sperandio daMediano, Mauro Felippe FelixSousa, Andrea Silvestre de2020-07-28T17:15:56Z2020-07-28T17:15:56Z2020HASSLOCHER-MORENO, Alejandro Marcel et al. Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort. Tropical Medicine and Infectious Disease, v. 5, n. 2, p. 1-11, 2020.2414-6366https://www.arca.fiocruz.br/handle/icict/4242310.3390/tropicalmed5020076engMDPIProgression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop the cardiac form. However, the actual rate of progression to the cardiac form is still unknown. Methods: In total, 550 patients with the indeterminate CD form were followed by means of annual electrocardiogram at our outpatient clinic. The studied endpoint was progression to cardiac form defined by the appearance of electrocardiographic changes typical of CD. The progression rate was calculated as the cumulative progression rate and the incidence progression rate per 100 patient years. Results: Thirty-seven patients progressed to the CD cardiac form within a mean of 73 ± 4 8 months of follow-up, which resulted in a 6.9% cumulative progression rate and incidence rate of 1.48 cases/100 patient years. Patients who progressed were older (mean age 47.8 ± 12.2 years), had a higher prevalence of associated heart diseases (p < 0.0001), positive xenodiagnosis (p = 0.007), and were born in the most endemic Brazilian states (p = 0.018). Previous co-morbidities remained the only variable associated with CD progression after multivariate Cox proportional hazards regression analysis (p = 0.002). Conclusion: The progression rate to chronic CD cardiac form is low and inferior to rates previously reported in other studies.Chagas diseaseDisease progressionElectrocardiogramHeart diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/42423/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALProgression_Alejandro_Hasslocher-Moreno_INI_2020.pdfProgression_Alejandro_Hasslocher-Moreno_INI_2020.pdfapplication/pdf446690https://www.arca.fiocruz.br/bitstream/icict/42423/2/Progression_Alejandro_Hasslocher-Moreno_INI_2020.pdfb5188d0066612a297749b363cfb5c39cMD52TEXTProgression_Alejandro_Hasslocher-Moreno_INI_2020.pdf.txtProgression_Alejandro_Hasslocher-Moreno_INI_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| title |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| spellingShingle |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort Hasslocher-Moreno, Alejandro Marcel Chagas disease Disease progression Electrocardiogram Heart disease |
| title_short |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| title_full |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| title_fullStr |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| title_full_unstemmed |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| title_sort |
Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort |
| author |
Hasslocher-Moreno, Alejandro Marcel |
| author_facet |
Hasslocher-Moreno, Alejandro Marcel Xavier, Sergio Salles Saraiva, Roberto Magalhães Sangenis, Luiz Henrique Conde Holanda, Marcelo Teixeira de Veloso, Henrique Horta Costa, Andrea Rodrigues da Mendes, Fernanda de Souza Nogueira Sardinha Brasil, Pedro Emmanuel Alvarenga Americano do Silva, Gilberto Marcelo Sperandio da Mediano, Mauro Felippe Felix Sousa, Andrea Silvestre de |
| author_role |
author |
| author2 |
Xavier, Sergio Salles Saraiva, Roberto Magalhães Sangenis, Luiz Henrique Conde Holanda, Marcelo Teixeira de Veloso, Henrique Horta Costa, Andrea Rodrigues da Mendes, Fernanda de Souza Nogueira Sardinha Brasil, Pedro Emmanuel Alvarenga Americano do Silva, Gilberto Marcelo Sperandio da Mediano, Mauro Felippe Felix Sousa, Andrea Silvestre de |
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author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Hasslocher-Moreno, Alejandro Marcel Xavier, Sergio Salles Saraiva, Roberto Magalhães Sangenis, Luiz Henrique Conde Holanda, Marcelo Teixeira de Veloso, Henrique Horta Costa, Andrea Rodrigues da Mendes, Fernanda de Souza Nogueira Sardinha Brasil, Pedro Emmanuel Alvarenga Americano do Silva, Gilberto Marcelo Sperandio da Mediano, Mauro Felippe Felix Sousa, Andrea Silvestre de |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Disease progression Electrocardiogram Heart disease |
| topic |
Chagas disease Disease progression Electrocardiogram Heart disease |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-07-28T17:15:56Z |
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2020-07-28T17:15:56Z |
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2020 |
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HASSLOCHER-MORENO, Alejandro Marcel et al. Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort. Tropical Medicine and Infectious Disease, v. 5, n. 2, p. 1-11, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42423 |
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2414-6366 |
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10.3390/tropicalmed5020076 |
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HASSLOCHER-MORENO, Alejandro Marcel et al. Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort. Tropical Medicine and Infectious Disease, v. 5, n. 2, p. 1-11, 2020. 2414-6366 10.3390/tropicalmed5020076 |
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