Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling

Detalhes bibliográficos
Autor(a) principal: Zanette, Dalila Lucíola
Data de Publicação: 2013
Outros Autores: Lorenzi, Julio Cesar Centrulo, Panepucci, Rodrigo Alexandre, Santos, A. R. D, Molfetta, Greici Andreotti de, Araujo, A. G, Silva Junior, Wilson Araújo da, Zago, Marco Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25840
Resumo: Zanette, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Zanette, Dalila LucíolaLorenzi, Julio Cesar CentruloPanepucci, Rodrigo AlexandreSantos, A. R. DMolfetta, Greici Andreotti deAraujo, A. GSilva Junior, Wilson Araújo daZago, Marco Antonio2018-04-13T18:12:41Z2018-04-13T18:12:41Z2013ZANETTE, D. L. et al. Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling. Genetics and Molecular Research, v. 12, n. 2, p. 1691-1697, 2013.1676-5680https://www.arca.fiocruz.br/handle/icict/2584010.4238/2013.May.15.1Zanette, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.FAPESP and CNPqUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilCentro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil / Centro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, BrasilCentro de Terapia Celular, Centro Regional de Hemoterapia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica Ribeirão Preto, SP, BrasilThe low number of hematopoietic stem cells (HSC) in umbilical cord blood (UCB) is directly related to increased risk of transplant failure. Effective ex vivo expansion of HSC has been tried for many years, with conflicting results because of the inability to reproduce in vitro HSC proliferation in the same way it occurs in vivo. We compared freshly isolated HSC with their expanded counterparts by microarray analysis and detected activation of the noncanonical Wnt (wingless-type MMTV integration site family) pathway. Study of early alterations during ex vivo UCB-HSC expansion could contribute to improvement of ex vivo expansion systems.engDesconhecidoSangue do cordão umbilicalCélula-troncoMicroarraysExpansão ex vivoHematopoiéticosUmbilical cord bloodHematopoietic stem cellMicroarraysEx vivo expansionMicroarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signalinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25840/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZanette DL Microarray profiles of ex vivo expanded....pdfZanette DL Microarray profiles of ex vivo 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dc.title.pt_BR.fl_str_mv Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
title Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
spellingShingle Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
Zanette, Dalila Lucíola
Sangue do cordão umbilical
Célula-tronco
Microarrays
Expansão ex vivo
Hematopoiéticos
Umbilical cord blood
Hematopoietic stem cell
Microarrays
Ex vivo expansion
title_short Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
title_full Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
title_fullStr Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
title_full_unstemmed Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
title_sort Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling
author Zanette, Dalila Lucíola
author_facet Zanette, Dalila Lucíola
Lorenzi, Julio Cesar Centrulo
Panepucci, Rodrigo Alexandre
Santos, A. R. D
Molfetta, Greici Andreotti de
Araujo, A. G
Silva Junior, Wilson Araújo da
Zago, Marco Antonio
author_role author
author2 Lorenzi, Julio Cesar Centrulo
Panepucci, Rodrigo Alexandre
Santos, A. R. D
Molfetta, Greici Andreotti de
Araujo, A. G
Silva Junior, Wilson Araújo da
Zago, Marco Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zanette, Dalila Lucíola
Lorenzi, Julio Cesar Centrulo
Panepucci, Rodrigo Alexandre
Santos, A. R. D
Molfetta, Greici Andreotti de
Araujo, A. G
Silva Junior, Wilson Araújo da
Zago, Marco Antonio
dc.subject.other.pt_BR.fl_str_mv Sangue do cordão umbilical
Célula-tronco
Microarrays
Expansão ex vivo
Hematopoiéticos
topic Sangue do cordão umbilical
Célula-tronco
Microarrays
Expansão ex vivo
Hematopoiéticos
Umbilical cord blood
Hematopoietic stem cell
Microarrays
Ex vivo expansion
dc.subject.en.pt_BR.fl_str_mv Umbilical cord blood
Hematopoietic stem cell
Microarrays
Ex vivo expansion
description Zanette, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-04-13T18:12:41Z
dc.date.available.fl_str_mv 2018-04-13T18:12:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZANETTE, D. L. et al. Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling. Genetics and Molecular Research, v. 12, n. 2, p. 1691-1697, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25840
dc.identifier.issn.pt_BR.fl_str_mv 1676-5680
dc.identifier.doi.none.fl_str_mv 10.4238/2013.May.15.1
identifier_str_mv ZANETTE, D. L. et al. Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling. Genetics and Molecular Research, v. 12, n. 2, p. 1691-1697, 2013.
1676-5680
10.4238/2013.May.15.1
url https://www.arca.fiocruz.br/handle/icict/25840
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Desconhecido
publisher.none.fl_str_mv Desconhecido
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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