Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25341 |
Resumo: | Instituto Nacional de Saúde, Universidade Pedagógica de Quelimane (UPQ), and Ministério da Ciência e Tecnologia, Ensino Superior e Técnico Profissional, Mozambique; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Instituto Gonçalo Moniz at Fundação Oswaldo Cruz, and Instituto de Saúde Coletiva a Universidade Federal da Bahia, Brazil |
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Mugabe, Vánio AndréAli, SádiaChelene, ImeldaMonteiro, Vanessa OnofreGuiliche, OnéliaMuianga, Argentina FelisbelaMula, FloraAntónio, VirgílioChongo, InocêncioOludele, JohnFalk, KerstinPaploski, Igor Adolfo DexheimerReis, Mitermayer Galvão dosKitron, UrielKümmerer, Beate MRibeiro, Guilherme de SousaGudo, Eduardo Samo2018-03-16T12:20:09Z2018-03-16T12:20:09Z2018MUGABE, Vánio André et al. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. Plos One, v. 13, n. 2, p. 1-13, 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/2534110.1371/journal.pone.0192110Instituto Nacional de Saúde, Universidade Pedagógica de Quelimane (UPQ), and Ministério da Ciência e Tecnologia, Ensino Superior e Técnico Profissional, Mozambique; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Instituto Gonçalo Moniz at Fundação Oswaldo Cruz, and Instituto de Saúde Coletiva a Universidade Federal da Bahia, BrazilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Pedagógica de Quelimane. Zambezia, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Public Health Agency of Sweden. Stockholm, Sweeden / Karolinska Institutet. Tumor and Cell Biology. Department of Microbiology. Stockholm, Sweden.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. Methods/Principal findings From February to June 2016, we conducted a cross-sectional study enrolling febrile patients attending five outpatient health units in Quelimane. Serum from each patient was tested for CHIKV and DENV, using IgM and IgG ELISA and qRT-PCR. Patients were also tested for malaria by RDT. Entomological surveys were performed around patients' households, and we calculated the proportion of positive ovitraps and the egg density per trap. A total of 163 patients were recruited, of which 99 (60.7%) were female. The median age was 28 years. IgM and IgG anti-CHIKV antibodies were identified in 17 (10.4%) and 103 (63.2%) patients, respectively. Plaque reduction neutralization assay confirmed the presence of anti-CHIKV antibodies in a subset of 11 tested patients with positive IgG results. IgM anti-DENV antibodies were found in 1 (0.9%) of 104 tested patients. Malaria was diagnosed in 35 (21.5%) patients, 2 of whom were also IgM-positive for CHIKV. Older age and lower education level were independently associated with the prevalence of IgG anti-CHIKV antibodies. Immature forms of Aedes aegypti were collected in 16 (20.3%) of 79 surveyed households. We also found that 25.0% (16/64) of the traps were positive, with an average of 90.8 eggs per pallet. Conclusions Our investigation demonstrated that no CHIKV outbreak was ongoing in Quelimane; rather, endemic transmission of the virus has been ongoing. Aedes aegypti mosquitoes are abundant, but dengue cases occurred only sporadically. Further population-based cohort studies are needed to improve our understanding of aspects related to the dynamics of arboviral transmission in Mozambique, as well as in other parts of Sub-Saharan Africa.engPublic Library of ScienceFebre ChikungunyaFebre da dengueTransmissãoHumanosChikungunya FeverDengue feverTransmissionHumansEvidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25341/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMugabe VA Evidence for chikungunya and dengue....pdfMugabe VA Evidence for chikungunya and 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| dc.title.pt_BR.fl_str_mv |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| title |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| spellingShingle |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus Mugabe, Vánio André Febre Chikungunya Febre da dengue Transmissão Humanos Chikungunya Fever Dengue fever Transmission Humans |
| title_short |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| title_full |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| title_fullStr |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| title_full_unstemmed |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| title_sort |
Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus |
| author |
Mugabe, Vánio André |
| author_facet |
Mugabe, Vánio André Ali, Sádia Chelene, Imelda Monteiro, Vanessa Onofre Guiliche, Onélia Muianga, Argentina Felisbela Mula, Flora António, Virgílio Chongo, Inocêncio Oludele, John Falk, Kerstin Paploski, Igor Adolfo Dexheimer Reis, Mitermayer Galvão dos Kitron, Uriel Kümmerer, Beate M Ribeiro, Guilherme de Sousa Gudo, Eduardo Samo |
| author_role |
author |
| author2 |
Ali, Sádia Chelene, Imelda Monteiro, Vanessa Onofre Guiliche, Onélia Muianga, Argentina Felisbela Mula, Flora António, Virgílio Chongo, Inocêncio Oludele, John Falk, Kerstin Paploski, Igor Adolfo Dexheimer Reis, Mitermayer Galvão dos Kitron, Uriel Kümmerer, Beate M Ribeiro, Guilherme de Sousa Gudo, Eduardo Samo |
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author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mugabe, Vánio André Ali, Sádia Chelene, Imelda Monteiro, Vanessa Onofre Guiliche, Onélia Muianga, Argentina Felisbela Mula, Flora António, Virgílio Chongo, Inocêncio Oludele, John Falk, Kerstin Paploski, Igor Adolfo Dexheimer Reis, Mitermayer Galvão dos Kitron, Uriel Kümmerer, Beate M Ribeiro, Guilherme de Sousa Gudo, Eduardo Samo |
| dc.subject.other.pt_BR.fl_str_mv |
Febre Chikungunya Febre da dengue Transmissão Humanos |
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Febre Chikungunya Febre da dengue Transmissão Humanos Chikungunya Fever Dengue fever Transmission Humans |
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Chikungunya Fever Dengue fever Transmission Humans |
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Instituto Nacional de Saúde, Universidade Pedagógica de Quelimane (UPQ), and Ministério da Ciência e Tecnologia, Ensino Superior e Técnico Profissional, Mozambique; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Instituto Gonçalo Moniz at Fundação Oswaldo Cruz, and Instituto de Saúde Coletiva a Universidade Federal da Bahia, Brazil |
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2018 |
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2018-03-16T12:20:09Z |
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2018-03-16T12:20:09Z |
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2018 |
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MUGABE, Vánio André et al. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. Plos One, v. 13, n. 2, p. 1-13, 2018. |
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https://www.arca.fiocruz.br/handle/icict/25341 |
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1932-6203 |
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10.1371/journal.pone.0192110 |
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MUGABE, Vánio André et al. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. Plos One, v. 13, n. 2, p. 1-13, 2018. 1932-6203 10.1371/journal.pone.0192110 |
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