Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection

Detalhes bibliográficos
Autor(a) principal: Cornell, Cristina Toledo
Data de Publicação: 2014
Outros Autores: Santos, Silvane, Orge, Gloria, Glesby, Marshall J, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24920
Resumo: CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Cornell, Cristina ToledoSantos, SilvaneOrge, GloriaGlesby, Marshall JCarvalho Filho, Edgar Marcelino2018-02-22T17:34:31Z2018-02-22T17:34:31Z2014CORNELL, C. T. et al. Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection. Journal of Medical Virology, v. 86, n. 2, p. 315–321, 2014.0146-6615https://www.arca.fiocruz.br/handle/icict/2492010.1002/jmv.23711CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health Office of the Director; Fogarty International Center; Office of AIDS Research; National Cancer Center; National Eye Institute; National Heart, Blood, and Lung Institute; National Institute of Dental and Craniofacial Research; National Institute on Drug Abuse; National Institute of Mental Health; National Institute of Allergy and Infectious Diseases; National Institutes of Health Office of Women’s Health; Fogarty International Clinical Research Scholars and Fellows Program at Vanderbilt University; Grant number: R24 TW007988.; American Relief and Recovery Act; Grant sponsor: NIH/NIAID; Grant numbers: K24 AI078884; NIH AI079238.Weill Cornell Medical College. Department of Medicine. Division of Infectious Diseases. New York, NYFederal University of Bahia. University Hospital Complexo Hospitalar Prof. Edgard Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, BrazilFederal University of Bahia. University Hospital Complexo Hospitalar Prof. Edgard Santos. Immunology Service. Salvador, BA, BrazilWeill Cornell Medical College. Department of Medicine. Division of Infectious Diseases. New York, NYFederal University of Bahia. University Hospital Complexo Hospitalar Prof. Edgard Santos. Immunology Service. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brazil / Bahian School of Medicine and Public Health. Salvador, BA, BrazilThe human T-cell leukemia virus (HTLV-1) is the causative agent of a variety of neurologic diseases, including HTLV-1 Associated Myelopathy (HAM/TSP) and overactive bladder. Investigation of immune markers such as soluble interleukin-2 receptor (sIL-2R) and beta-2 microglobulin (B2M) has shown some promising results in distinguishing patients with neurologic disease from those with carrier status. The objective of the present study was to determine if plasma levels of sIL-2R and B2M are markers of neurologic disease in individuals infected with HTLV-1. The present study was divided into two parts. A cross-sectional study and a nested case control study. In the cross-sectional study, HAM/TSP patients had higher plasma levels of B2M and sIL-2R than patients with overactive bladder and HTLV-1 carriers (P < 0.01 for all comparisons). For the nested case control study, the sIL-2 receptor test was able to distinguish patients with HAM/TSP from patients in the combined group of carriers and patients with overactive bladder with a sensitivity of 75.8% and false positive rate of 25.4%. Plasma levels of these markers did not change with the development of HAM/TSP and overactive bladder in HTLV-1 carrier patients. The present study has shown the importance of sIL-2 receptor in helping identifying HAM/TSP. However, the levels of these makers did not change significantly with the development of neurologic disease.engWileyHTLV-1HAM / TSPDoença neurológicasIL-2RBeta-2 microglobulinaHTLV-1HAM/TSPNeurologic diseasesIL-2RBeta-2 microglobulinSoluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24920/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCornell CT Soluble IL-2 receptor and beta-2....pdfCornell CT Soluble IL-2 receptor and 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dc.title.pt_BR.fl_str_mv Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
title Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
spellingShingle Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
Cornell, Cristina Toledo
HTLV-1
HAM / TSP
Doença neurológica
sIL-2R
Beta-2 microglobulina
HTLV-1
HAM/TSP
Neurologic disease
sIL-2R
Beta-2 microglobulin
title_short Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
title_full Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
title_fullStr Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
title_full_unstemmed Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
title_sort Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection
author Cornell, Cristina Toledo
author_facet Cornell, Cristina Toledo
Santos, Silvane
Orge, Gloria
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
author_role author
author2 Santos, Silvane
Orge, Gloria
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cornell, Cristina Toledo
Santos, Silvane
Orge, Gloria
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
dc.subject.other.pt_BR.fl_str_mv HTLV-1
HAM / TSP
Doença neurológica
sIL-2R
Beta-2 microglobulina
topic HTLV-1
HAM / TSP
Doença neurológica
sIL-2R
Beta-2 microglobulina
HTLV-1
HAM/TSP
Neurologic disease
sIL-2R
Beta-2 microglobulin
dc.subject.en.pt_BR.fl_str_mv HTLV-1
HAM/TSP
Neurologic disease
sIL-2R
Beta-2 microglobulin
description CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-02-22T17:34:31Z
dc.date.available.fl_str_mv 2018-02-22T17:34:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CORNELL, C. T. et al. Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection. Journal of Medical Virology, v. 86, n. 2, p. 315–321, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24920
dc.identifier.issn.pt_BR.fl_str_mv 0146-6615
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.23711
identifier_str_mv CORNELL, C. T. et al. Soluble IL-2 receptor and beta-2 microglobulin as possible serologic markers of neurologic disease in HTLV-1 infection. Journal of Medical Virology, v. 86, n. 2, p. 315–321, 2014.
0146-6615
10.1002/jmv.23711
url https://www.arca.fiocruz.br/handle/icict/24920
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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