Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection

Detalhes bibliográficos
Autor(a) principal: Tavares, Luciana P.
Data de Publicação: 2022
Outros Autores: Brüggemann, Thayse R., Rezende, Rafael M., Machado, Marina G., Cagnina, R. Elaine, Shay, Ashley E., Garcia, Cristiana, Nijmeh, Julie, Teixeira, Mauro M., Levy, Bruce D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55058
Resumo: Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.
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spelling Tavares, Luciana P.Brüggemann, Thayse R.Rezende, Rafael M.Machado, Marina G.Cagnina, R. ElaineShay, Ashley E.Garcia, CristianaNijmeh, JulieTeixeira, Mauro M.Levy, Bruce D.2022-10-10T11:34:32Z2022-10-10T11:34:32Z2022TAVARES, Luciana P. et al. Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection. American Society for Microbiology, v.13, n. 4, p. 1 - 16, July/August 2022.2150-7511https://www.arca.fiocruz.br/handle/icict/55058engAmerican Society for MicrobiologyVírus da gripe AStreptococcus pneumoniaeResolução da inflamaçãoMediadores pró-resoluçãoConjugados de maresina na regeneração de tecidos (MCTRs)Macrófagos alveolaresInfecção secundáriaInfluenza A virusStreptococcus pneumoniaeResolution of inflammationProresolving mediatorsMaresin conjugates in tissue regeneration (MCTRs),Alveolar macrophagesSecondary infectionCysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USACenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial infections, particularly pneumonia caused by Streptococcus pneumoniae. Resident alveolar macrophages (rAMs) are early responders to respiratory infections that coordinate initial host defense responses. Maresin conjugates in tissue regeneration (MCTRs) are recently elucidated cysteinyl maresins that are produced by and act on macrophages. Roles for MCTRs in responses to respiratory infections remain to be determined. Here, IAV infection led to transient decreases in rAM numbers. Repopulated lung macrophages displayed transcriptional alterations 21 days post-IAV with prolonged susceptibility to secondary pneumococcal infection. Administration of a mix of MCTR1 to 3 or MCTR3 alone post-IAV decreased lung inflammation and bacterial load 48 and 72 h after secondary pneumococcal infection. MCTR-exposed rAMs had increased migration and phagocytosis of Streptococcus pneumoniae, reduced secretion of CXCL1, and a reversion toward baseline levels of several IAVinduced pneumonia susceptibility genes. Together, MCTRs counter regulated post-IAV changes in rAMs to promote a rapid return of bacteria host defense. IMPORTANCE Secondary bacterial pneumonia is a serious and common complication of IAV infection, leading to excess morbidity and mortality. New host-directed approaches are needed to complement antibiotics to better address this important global infectious disease. Here, we show that harnessing endogenous resolution mechanisms for inflammation by exogenous administration of a family of specialized proresolving mediators (i.e., cys-MCTRs) increased macrophage resilience mechanisms after IAV to protect against secondary infection from Streptococcus pneumoniae.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55058/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCristiana_Garcia_etal_IOC_2022.pdfCristiana_Garcia_etal_IOC_2022.pdfapplication/pdf3423714https://www.arca.fiocruz.br/bitstream/icict/55058/2/Cristiana_Garcia_etal_IOC_2022.pdf21d83f6023b4319038aa5392d49653d9MD52icict/550582023-09-14 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dc.title.en_US.fl_str_mv Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
title Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
spellingShingle Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
Tavares, Luciana P.
Vírus da gripe A
Streptococcus pneumoniae
Resolução da inflamação
Mediadores pró-resolução
Conjugados de maresina na regeneração de tecidos (MCTRs)
Macrófagos alveolares
Infecção secundária
Influenza A virus
Streptococcus pneumoniae
Resolution of inflammation
Proresolving mediators
Maresin conjugates in tissue regeneration (MCTRs),
Alveolar macrophages
Secondary infection
title_short Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
title_full Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
title_fullStr Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
title_full_unstemmed Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
title_sort Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
author Tavares, Luciana P.
author_facet Tavares, Luciana P.
Brüggemann, Thayse R.
Rezende, Rafael M.
Machado, Marina G.
Cagnina, R. Elaine
Shay, Ashley E.
Garcia, Cristiana
Nijmeh, Julie
Teixeira, Mauro M.
Levy, Bruce D.
author_role author
author2 Brüggemann, Thayse R.
Rezende, Rafael M.
Machado, Marina G.
Cagnina, R. Elaine
Shay, Ashley E.
Garcia, Cristiana
Nijmeh, Julie
Teixeira, Mauro M.
Levy, Bruce D.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tavares, Luciana P.
Brüggemann, Thayse R.
Rezende, Rafael M.
Machado, Marina G.
Cagnina, R. Elaine
Shay, Ashley E.
Garcia, Cristiana
Nijmeh, Julie
Teixeira, Mauro M.
Levy, Bruce D.
dc.subject.other.en_US.fl_str_mv Vírus da gripe A
Streptococcus pneumoniae
Resolução da inflamação
Mediadores pró-resolução
Conjugados de maresina na regeneração de tecidos (MCTRs)
Macrófagos alveolares
Infecção secundária
topic Vírus da gripe A
Streptococcus pneumoniae
Resolução da inflamação
Mediadores pró-resolução
Conjugados de maresina na regeneração de tecidos (MCTRs)
Macrófagos alveolares
Infecção secundária
Influenza A virus
Streptococcus pneumoniae
Resolution of inflammation
Proresolving mediators
Maresin conjugates in tissue regeneration (MCTRs),
Alveolar macrophages
Secondary infection
dc.subject.en.en_US.fl_str_mv Influenza A virus
Streptococcus pneumoniae
Resolution of inflammation
Proresolving mediators
Maresin conjugates in tissue regeneration (MCTRs),
Alveolar macrophages
Secondary infection
description Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas,. Laboratório de Imunofarmacologia,. Belo Horizonte, MG, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-10T11:34:32Z
dc.date.available.fl_str_mv 2022-10-10T11:34:32Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TAVARES, Luciana P. et al. Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection. American Society for Microbiology, v.13, n. 4, p. 1 - 16, July/August 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55058
dc.identifier.issn.en_US.fl_str_mv 2150-7511
identifier_str_mv TAVARES, Luciana P. et al. Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection. American Society for Microbiology, v.13, n. 4, p. 1 - 16, July/August 2022.
2150-7511
url https://www.arca.fiocruz.br/handle/icict/55058
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55058/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55058/2/Cristiana_Garcia_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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